Results 21 to 30 of about 3,119,335 (269)

ALDH1a3 Protects Against Iron Overload−Induced Oxidative Stress and Mitochondrial Impairment in Renal Tubular Epithelial Cells

Antioxidants
Iron overload significantly contributes to chronic kidney disease progression by triggering oxidative stress and mitochondrial impairment via the Fenton reaction.
Tingting Wei, Zongliang Xiong, Tianci Wang, Chao Huang, Qihui Luo, Riyi Shi, Lanlan Jia, Wentao Liu, Donghui Yang, Zhengli Chen   +9 more
doaj   +1 more source

INVARIANT MODEL FOR ESTIMATION OF THE ATMOSPHERE TRANSMITTING EFFICIENCY AT OBJECTS MONITORING IN THE OPTICAL SPECTRAL RANGE [PDF]

Научно-технический вестник информационных технологий, механики и оптики, 2012
Estimation problem of the atmosphere influence on radiation in the middle and distant infra-red range for the increasing of results reliability at aircraft monitoring is considered.
A. V. Demin, M. Ianalytical model, identification, the atmosphere transmitting efficiency, objects monitoring, experimental data. Moiseeva   +1 more
doaj  

Experimental Models of Cryptococcosis [PDF]

International Journal of Microbiology, 2012
Cryptococcosis is a life-threatening fungal disease that infects around one million people each year. Establishment and progression of disease involves a complex interplay between the fungus and a diverse range of host cell types. Over recent years, numerous cellular, tissue, and animal models have been exploited to probe this host-pathogen interaction.
Wilber Sabiiti, Robin C. May, E. Rhiannon Pursall   +2 more
openaire   +5 more sources

Evolution of the Experimental Models of Cholangiocarcinoma [PDF]

Cancers, 2020
Cholangiocarcinoma (CCA) is a rare, aggressive disease with poor overall survival. In advanced cases, surgery is often not possible or fails; in addition, there is a lack of effective and specific therapies. Multidisciplinary approaches and advanced technologies have improved the knowledge of CCA molecular pathogenesis, highlighting its extreme ...
Massa, Annamaria, Varamo, Chiara, Vita, Francesca, Tavolari, Simona, Peraldo-Neia, Caterina, Brandi, Giovanni, Rizzo, Alessandro, Cavalloni, Giuliana, Aglietta, Massimo   +8 more
openaire   +3 more sources

Dimercaprol Reprograms Intestinal Redox Homeostasis and Organelle Crosstalk to Combat Iron-Induced Gut Dysbiosis Through NRF2/HO-1 Signaling

Antioxidants
Gut disorders are largely caused by iron-induced microbial dysbiosis. Excess iron disrupts barrier integrity by inducing oxidative stress, leading to impaired cellular processes.
Asad Khan, Zongliang Xiong, Iftikhar Ali Khan, Xiangyu Cheng, Qihui Luo, Lanlan Jia, Wentao Liu, Chao Huang, Zhengli Chen   +8 more
doaj   +1 more source

LanCL2 Implicates in Testicular Redox Homeostasis and Acrosomal Maturation

Antioxidants
Redox balance plays an important role in testicular homeostasis. While lots of antioxidant molecules have been identified as widely expressed, the understanding of the critical mechanisms for redox management in male germ cells is inadequate.
Yanling Zhao, Jichen Wang, Shuai Shi, Xinting Lan, Xiangyu Cheng, Lixia Li, Yuanfeng Zou, Lanlan Jia, Wentao Liu, Qihui Luo, Zhengli Chen, Chao Huang   +11 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Cup‐Like Nuclei Is a Hallmark of DUX4/ERG Acute Lymphoblastic Leukemia and Reveals Cytoplasmic Mitochondria Accumulation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Cup‐like nuclei are a distinctive morphological feature observed in certain cases of acute lymphoblastic leukemia (ALL). We provide evidence that they characterize DUX4/ERG ALL independently of IKZF1 deletion and reveal marked mitochondrial accumulation in this ALL subset.
Chloé Arfeuille, Hugo Roux, Odile Fenneteau, Aurélie Caye‐Eude, Alexia Kinoo, Yoann Vial, André Baruchel, Marion Strullu, Elodie Lainey, Hélène Cavé   +9 more
wiley   +1 more source

Experimental Models [PDF]

Stroke, 2009
Although many potential therapeutics have improved motor and cognitive function in animal models of experimental stroke, very few have been found to have similar beneficial effects in clinical trials. In this review, we examine the advantages and disadvantages of the currently available rodent models in the development of cellular therapies for stroke ...
openaire   +2 more sources

The Combined Effect of Obesity and Contraceptive Use on Pulmonary Embolism in Adolescent Females Residing in the United States

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Combined oral contraceptive (COC) use in obese adult women dramatically increases the relative risk of developing a pulmonary embolism (PE). The risk of a PE in obese adolescent females taking contraceptives is currently unknown. The purpose of this investigation was to determine the effect of body mass index (BMI) and contraceptive
John Puetz, Joanne Salas
wiley   +1 more source