Matrin 3 and HIV Rev Regulation of mRNA [PDF]
, 2011 The nuclear matrix protein, MATR3, is a newly-described Rev cofactor whose mechanism of action is only starting to be revealed.
Andrew I Dayton
core +1 more source
The mouse KLF1 Nan variant impairs nuclear condensation and erythroid maturation.
PLoS ONE, 2019 Krüppel-like factor 1 (KLF1) is an essential transcription factor for erythroid development, as demonstrated by Klf1 knockout mice which die around E14 due to severe anemia. In humans, >140 KLF1 variants, causing different erythroid phenotypes, have been
Ileana Cantú +12 more
doaj +1 more source
Exportin 1/chromosome region maintenance 1 as a therapeutic target for lung cancer. [PDF]
Transl Cancer Res, 2017 Gao W.
europepmc +4 more sources
American Journal of Hematology, EarlyView.ABSTRACT Patients with relapsed/refractory multiple myeloma (RRMM) who are penta‐drug refractory, defined as resistant to two proteasome inhibitors, two immunomodulatory agents, and an anti‐CD38 monoclonal antibody, face a dismal prognosis, particularly after exposure to T‐cell–redirecting therapies.
Maximilian Al‐Bazaz +22 more
wiley +1 more source
Nucleo-cytoplasmic transport of proteins and RNA in plants [PDF]
, 2010 Merkle T. Nucleo-cytoplasmic transport of proteins and RNA in plants. Plant Cell Reports. 2011;30(2):153-176.Transport of macromolecules between the nucleus and the cytoplasm is an essential necessity in eukaryotic cells, since the nuclear envelope ...
Thomas Merkle
core +2 more sources
The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding
Animal Research and One Health, EarlyView.A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang +10 more
wiley +1 more source
Alternative Splicing of Staufen2 Creates the Nuclear Export Signal for CRM1 (Exportin 1) [PDF]
Journal of Biological Chemistry, 2004 Mammalian Staufen2 (Stau2), a brain-specific double-stranded RNA-binding protein, is involved in the localization of mRNA in neurons. To gain insights into the function of Stau2, the subcellular localization of Stau2 isoforms fused to the green fluorescence protein was examined.
Takashi, Miki, Yoshihiro, Yoneda
openaire +2 more sources
The T-loop extension of the tomato protein Kinase AvrPto-dependent Pto-interacting Protein 3 (Adi3) directs nuclear localization for suppression of plant cell death [PDF]
, 2010 In tomato (Solanum lycopersicum), resistance to Pseudomonas syringae pv. tomatois elicited by the interaction of the host Pto kinase with the pathogen effector protein AvrPto, which leads to various immune responses including localized cell death termed ...
María J. Ek-Ramos +77 more
core +2 more sources
Role of SoxE transcription factors in development and disease
Developmental Dynamics, EarlyView.Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley +1 more source
RXRα acts as a carrier for TR3 nuclear export in a 9-cis retinoic acid-dependent manner in gastric cancer cells [PDF]
, 2004 Retinoid X receptor (RXR) plays a crucial role in the cross talk between retinoid receptors and other hormone receptors including the orphan receptor TR3, forming different heterodimers that transduce diverse steroid/thyroid hormone signaling.
Chen, HZ +10 more
core +1 more source