Results 51 to 60 of about 27,541,156 (167)

Loss of p53 expression in cancer cells alters cell cycle response after inhibition of exportin-1 but does not prevent cell death [PDF]

Cell Cycle, 2018
James Orth, Soyeon Park
exaly   +2 more sources

Involvement of Exportin 1 Mediated c-Myc and Cullin 4A Signaling in Apoptotic Effect of Fisetin in Non-small Cell Lung Cancer Cells

Journal of Oncology Research and Therapeutics, 2023
of Exportin 1 Mediated c ...
J. Young, Hyemin Lee, Ji Eon, P. Deok, Y. Sim, Hyo-Jung Lee, Chi-Hoon Ahn, Su Yeon Park, B. Shim, Bonglee Kim, Sung-Hoon Kim   +10 more
semanticscholar   +1 more source

Strength in Diversity: Nuclear Export of Viral RNAs

Viruses, 2020
The nuclear export of cellular mRNAs is a complex process that requires the orchestrated participation of many proteins that are recruited during the early steps of mRNA synthesis and processing.
Jón Pol Gales, Julie Kubina, Angèle Geldreich, Maria Dimitrova   +3 more
doaj   +1 more source

Exportin 1 Mediates Nuclear Export of the Kinetoplastid Spliced Leader RNA [PDF]

Eukaryotic Cell, 2003
ABSTRACTThe kinetoplastid protozoan spliced leader (SL) RNA is the common substrate pre-mRNA utilized in alltrans-splicing reactions. Here we show by fluorescence in situ hybridization that the SL RNA is present in the cytoplasm ofLeishmania tarentolaeandTrypanosoma brucei.
Gusti M, Zeiner, Nancy R, Sturm, David A, Campbell   +2 more
openaire   +2 more sources

Effect of exportin 1/XPO1 nuclear export pathway inhibition on coronavirus replication

bioRxiv, 2023
Nucleocytoplasmic transport of proteins using XPO1 (exportin 1) plays a vital role in cell proliferation and survival. Many viruses also exploit this pathway to promote infection and replication.
Masmudur M. Rahman, Bereket Estifanos, Honor L. Glenn, Ami D Gutierrez-Jensen, Karen Kibler, Y. Li, Bertram Jacobs, G. McFadden, B. Hogue   +8 more
semanticscholar   +1 more source

Selinexor and COVID-19: The Neglected Warden

Frontiers in Pharmacology, 2022
A novel severe acute respiratory distress syndrome coronavirus type 2 (SARS-CoV-2) has been confirmed as the cause of the global pandemic coronavirus disease 2019 (COVID-19).
Gomaa Mostafa-Hedeab, Gomaa Mostafa-Hedeab, Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Nermeen N. Welson, Gaber El-Saber Batiha, Carlos Adam Conte-Junior   +6 more
doaj   +1 more source

An Exportin-1-dependent microRNA biogenesis pathway during human cell quiescence. [PDF]

Proc Natl Acad Sci U S A, 2017
Significance Quiescence is a growth-arrested cellular state; genes involved in this process are finely regulated by several factors, including miRNAs. During miRNA biogenesis, Exportin-5 transports miRNA precursors from the nucleus to the cytoplasm.
Martinez I, Hayes KE, Barr JA, Harold AD, Xie M, Bukhari SIA, Vasudevan S, Steitz JA, DiMaio D.   +8 more
europepmc   +4 more sources

Discovery of Eriodictyol as Putative Exportin-1 Inhibitor for Non-small Cell Lung Cancer Therapy

African Scientist, 2023
Exportin-1, the ubiquitous nuclear protein transporter, is widely confirmed as an active chemotherapeutic target in non-small cell lung cancer conditions, while Juglans mandshurica is a well-studied anticancer plant in some lung cancer cell lines.
T. Adigun, F. Sulaiman, A. Na’Allah, M. Alabi, C. E. Odo, E. T. Adebamiji, I. A. Oluwadare, U. Ozojiofor, Adedayo Pius Omoniyi, Wisdom O. Joel, Kehinde O. Aina, O. Alejolowo, S. Akiode, J. F. Adeegbe   +13 more
semanticscholar   +1 more source

A highly potent small-molecule antagonist of exportin-1 selectively eliminates CD44+CD24- enriched breast cancer stem-like cells.

Drug resistance updates, 2022
Breast cancer stem-like cells (BCSCs) have been suggested as the underlying cause of tumor recurrence, metastasis and drug resistance in triple-negative breast cancer (TNBC).
Caigang Liu, Yixiao Zhang, Jiujiao Gao, Qi Zhang, Lisha Sun, Qingtian Ma, X. Qiao, Xinnan Li, Jinchi Liu, Jiawen Bu, Zhan Zhang, Ling Han, Dongyu Zhao, Yongliang Yang   +13 more
semanticscholar   +1 more source

Differential expression of exportin 1 in cancers of the breast.

, 2022
Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with early-onset breast cancer.
openaire   +1 more source