Results 51 to 60 of about 30,000,744 (172)
Nuclear exportin receptor CAS regulates the NPI-1-mediated nuclear import of HIV-1 Vpr. [PDF]
PLoS ONE, 2011 Vpr, an accessory protein of human immunodeficiency virus type 1, is a multifunctional protein that plays an important role in viral replication. We have previously shown that the region between residues 17 and 74 of Vpr (Vpr(N17C74)) contained a bona ...
Eri Takeda +6 more
doaj +1 more source
The evolution of core proteins involved in microRNA biogenesis
BMC Evolutionary Biology, 2008 Background MicroRNAs (miRNAs) are a recently discovered class of non-coding RNAs (ncRNAs) which play important roles in eukaryotic gene regulation. miRNA biogenesis and activation is a complex process involving multiple protein catalysts and involves the
Brown James R +2 more
doaj +1 more source
Exportin 1/chromosome region maintenance 1 as a therapeutic target for lung cancer. [PDF]
Transl Cancer Res, 2017 Gao W.
europepmc +4 more sources
Small-Molecule Antagonist Targeting Exportin‑1 via Rational Structure-Based Discovery
, 2020 Exportin-1 (also named as CRM1) plays a prominent role in autoimmune disorders and has emerged as a potential therapeutic target for colitis. Here we report on the rational structure-based discovery of a small-molecule antagonist of exportin-1, LFS-829 ...
Xiangyu Long +33 more
core +2 more sources
Exportin 1 Mediates Nuclear Export of the Kinetoplastid Spliced Leader RNA [PDF]
Eukaryotic Cell, 2003 ABSTRACTThe kinetoplastid protozoan spliced leader (SL) RNA is the common substrate pre-mRNA utilized in alltrans-splicing reactions. Here we show by fluorescence in situ hybridization that the SL RNA is present in the cytoplasm ofLeishmania tarentolaeandTrypanosoma brucei.
Gusti M, Zeiner +2 more
openaire +2 more sources
Strength in Diversity: Nuclear Export of Viral RNAs
Viruses, 2020 The nuclear export of cellular mRNAs is a complex process that requires the orchestrated participation of many proteins that are recruited during the early steps of mRNA synthesis and processing.
Jón Pol Gales +3 more
doaj +1 more source
Selinexor and COVID-19: The Neglected Warden
Frontiers in Pharmacology, 2022 A novel severe acute respiratory distress syndrome coronavirus type 2 (SARS-CoV-2) has been confirmed as the cause of the global pandemic coronavirus disease 2019 (COVID-19).
Gomaa Mostafa-Hedeab +6 more
doaj +1 more source
, 2021 Supplemental material, sj-tif-1-tct-10.1177_15330338211039132 for Exportin-T: A Novel Prognostic Predictor and Potential Therapeutic Target for Neuroblastoma by Li-Jia Pan, Jian-Lei Chen, Zhi-Xiang Wu and Ye-Ming Wu in Technology in Cancer Research ...
Li-Jia Pan (11377147) +3 more
core +1 more source
The mouse KLF1 Nan variant impairs nuclear condensation and erythroid maturation.
PLoS ONE, 2019 Krüppel-like factor 1 (KLF1) is an essential transcription factor for erythroid development, as demonstrated by Klf1 knockout mice which die around E14 due to severe anemia. In humans, >140 KLF1 variants, causing different erythroid phenotypes, have been
Ileana Cantú +12 more
doaj +1 more source
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source