Nuclear DDX3 expression predicts poor outcome in colorectal and breast cancer [PDF]
, 2017 Purpose: DEAD box protein 3 (DDX3) is an RNA helicase with oncogenic properties that shuttles between the cytoplasm and nucleus. The majority of DDX3 is found in the cytoplasm, but a subset of tumors has distinct nuclear DDX3 localization of yet unknown ...
Bol, Guus M. +10 more
core +2 more sources
The nuclear export factor CRM1 controls juxta-nuclear microtubule-dependent virus transport [PDF]
, 2017 Transport of large cargo through the cytoplasm requires motor proteins and polarized filaments. Viruses that replicate in the nucleus of post-mitotic cells use microtubules and the dynein/dynactin motor to traffic to the nuclear membrane, and deliver ...
Wang, I-Hsuan +4 more
core +4 more sources
Selinexor overcomes hypoxia-induced drug resistance in multiple myeloma [PDF]
, 2017 Increased levels of the nuclear export protein, exportin 1 (XPO1), were demonstrated in multiple myeloma (MM) patients. Targeting XPO1 with selinexor (the selective inhibitor of nuclear export; SINE compound KPT-330) demonstrates broad antitumor activity
Azab, Abdel Kareem +4 more
core +3 more sources
Exportin 1 Mediates Nuclear Export of the Kinetoplastid Spliced Leader RNA [PDF]
Eukaryotic Cell, 2003 ABSTRACTThe kinetoplastid protozoan spliced leader (SL) RNA is the common substrate pre-mRNA utilized in alltrans-splicing reactions. Here we show by fluorescence in situ hybridization that the SL RNA is present in the cytoplasm ofLeishmania tarentolaeandTrypanosoma brucei.
Gusti M, Zeiner +2 more
openaire +2 more sources
Strength in Diversity: Nuclear Export of Viral RNAs
Viruses, 2020 The nuclear export of cellular mRNAs is a complex process that requires the orchestrated participation of many proteins that are recruited during the early steps of mRNA synthesis and processing.
Jón Pol Gales +3 more
doaj +1 more source
RCC1-dependent activation of Ran accelerates cell cycle and DNA repair, inhibiting DNA damage–induced cell senescence [PDF]
, 2016 © The Author(s), 2016. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Molecular Biology of the Cell 27 (2016): 1346-1357, doi:10.1091/mbc.E16-01-0025.The coordination of ...
Cekan, Pavol +8 more
core +1 more source
Characterizing the normal proteome of human ciliary body [PDF]
, 2013 BACKGROUND: The ciliary body is the circumferential muscular tissue located just behind the iris in the anterior chamber of the eye. It plays a pivotal role in the production of aqueous humor, maintenance of the lens zonules and accommodation by changing
Akhilesh Pandey +13 more
core +1 more source
Selinexor and COVID-19: The Neglected Warden
Frontiers in Pharmacology, 2022 A novel severe acute respiratory distress syndrome coronavirus type 2 (SARS-CoV-2) has been confirmed as the cause of the global pandemic coronavirus disease 2019 (COVID-19).
Gomaa Mostafa-Hedeab +6 more
doaj +1 more source
Antileukemic Activity of Nuclear Export Inhibitors that Spare Normal Hematopoietic Cells [PDF]
, 2012 Drugs that target the chief mediator of nuclear export, chromosome region maintenance 1 protein (CRM1) have potential as therapeutics for leukemia, but existing CRM1 inhibitors show variable potencies and a broad range of cytotoxic effects.
Barcelo, C +15 more
core +1 more source
An agent-based model for mRNA export through the nuclear pore complex. [PDF]
, 2014 mRNA export from the nucleus is an essential step in the expression of every protein- coding gene in eukaryotes, but many aspects of this process remain poorly understood.
Azimi, Mohammad +3 more
core +2 more sources