Results 41 to 50 of about 27,541,156 (167)

The nuclear export receptor OsXPO1 is required for rice development and involved in abiotic stress responses

Crop Journal, 2023
The transport of proteins to and from the nucleus is necessary for many cellular processes and is one of the ways plants respond to developmental signals and environmental stresses.
Qiufei Peng, Jieyu Qiu, Xintong Li, Xuezhong Xu, Xinxiang Peng, Guohui Zhu   +5 more
doaj   +1 more source

Combined Targeting of Estrogen Receptor Alpha and Exportin 1 in Metastatic Breast Cancers. [PDF]

Cancers (Basel), 2020
The majority of breast cancer specific deaths in women with estrogen receptor positive (ER+) tumors occur due to metastases that are resistant to therapy. There is a critical need for novel therapeutic approaches to achieve tumor regression and/or maintain therapy responsiveness in metastatic ER+ tumors. The objective of this study was to elucidate the
Cotul EK, Zuo Q, Santaliz-Casiano A, Imir OB, Mogol AN, Tunc E, Duong K, Lee JK, Ramesh R, Odukoya E, Kesavadas MP, Ziogaite M, Smith BP, Mao C, Shapiro DJ, Park BH, Katzenellenbogen BS, Daly D, Aranda E, O'Neill JD, Walker C, Landesman Y, Madak-Erdogan Z.   +22 more
europepmc   +4 more sources

SINE compounds activate exportin-1 degradation via an allosteric mechanism

bioRxiv
The nuclear export receptor exportin 1 (XPO1/CRM1) is often overexpressed in cancer cells, leading to the mislocalization of numerous cancer-related protein cargoes 1,2 . Selinexor, a covalent XPO1 inhibitor, and other Selective Inhibitor of Nuclear Export (SINEs) restore proper nuclear ...
Casey E. Wing, H. Fung, B. Kwanten, T. Cagatay, Ashley B. Niesman, M. Jacquemyn, Mehdi Gharghabi, Brecht Permentier, Binita Shakya, Rhituparna Nandi, Joseph A. Ready, T. Kashyap, S. Shacham, Y. Landesman, R. Lapalombella, D. Daelemans, Y. Chook   +16 more
semanticscholar   +3 more sources

Orientia tsutsugamushi uses two Ank effectors to modulate NF-κB p65 nuclear transport and inhibit NF-κB transcriptional activation.

PLoS Pathogens, 2018
Orientia tsutsugamushi causes scrub typhus, a potentially fatal infection that threatens over one billion people. Nuclear translocation of the transcription factor, NF-κB, is the central initiating cellular event in the antimicrobial response.
Sean M Evans, Kyle G Rodino, Haley E Adcox, Jason A Carlyon   +3 more
doaj   +1 more source

Preclinical antitumor efficacy of selective exportin 1 inhibitors in glioblastoma. [PDF]

Neuro Oncol, 2015
Glioblastoma (GBM) is poorly responsive to current chemotherapy. The nuclear transporter exportin 1 (XPO1, CRM1) is often highly expressed in GBM, which may portend a poor prognosis. Here, we determine the efficacy of novel selective inhibitors of nuclear export (SINE) specific to XPO1 in preclinical models of GBM.Seven patient-derived GBM lines were ...
Green AL, Ramkissoon SH, McCauley D, Jones K, Perry JA, Hsu JH, Ramkissoon LA, Maire CL, Hubbell-Engler B, Knoff DS, Shacham S, Ligon KL, Kung AL.   +12 more
europepmc   +4 more sources

Structural determinants of nuclear export signal orientation in binding to exportin CRM1

eLife, 2015
The Chromosome Region of Maintenance 1 (CRM1) protein mediates nuclear export of hundreds of proteins through recognition of their nuclear export signals (NESs), which are highly variable in sequence and structure.
Ho Yee Joyce Fung, Szu-Chin Fu, Chad A Brautigam, Yuh Min Chook   +3 more
doaj   +1 more source

Nuclear exportin receptor CAS regulates the NPI-1-mediated nuclear import of HIV-1 Vpr. [PDF]

PLoS ONE, 2011
Vpr, an accessory protein of human immunodeficiency virus type 1, is a multifunctional protein that plays an important role in viral replication. We have previously shown that the region between residues 17 and 74 of Vpr (Vpr(N17C74)) contained a bona ...
Eri Takeda, Tomoyuki Murakami, Go Matsuda, Hironobu Murakami, Tamotsu Zako, Mizuo Maeda, Yoko Aida   +6 more
doaj   +1 more source

The evolution of core proteins involved in microRNA biogenesis

BMC Evolutionary Biology, 2008
Background MicroRNAs (miRNAs) are a recently discovered class of non-coding RNAs (ncRNAs) which play important roles in eukaryotic gene regulation. miRNA biogenesis and activation is a complex process involving multiple protein catalysts and involves the
Brown James R, Dancis Barry, Murphy Dennis   +2 more
doaj   +1 more source

Exportin 1 is required for the reproduction and maize mosaic virus accumulation in its insect vector Peregrinus maidis

bioRxiv, 2023
Exportin 1 (XPO1) is the major karyopherin-β nuclear receptor mediating the nuclear export of hundreds of proteins and some classes of RNA and regulates several critical processes in the cell, including but not limited to, cell-cycle progression ...
César A. D. Xavier, Clara Tyson, Leo M. Kerner, A. Whitfield   +3 more
semanticscholar   +1 more source

Differential impact of exportin-1-mediated nuclear export of RNAs on the RNA content of extracellular vesicle subpopulations

Biologia Futura, 2023
Extracellular vesicles (EVs) are membrane-enclosed subcellular structures released by all cell types. EVs have important roles in both cellular homeostasis and intercellular communication.
K. Pálóczi, E. Buzás, A. Falus
semanticscholar   +1 more source