Results 41 to 50 of about 30,000,744 (172)

Inhibition of XPO-1 Mediated Nuclear Export through the Michael-Acceptor Character of Chalcones

Pharmaceuticals, 2021
The nuclear export receptor exportin-1 (XPO1, CRM1) mediates the nuclear export of proteins that contain a leucine-rich nuclear export signal (NES) towards the cytoplasm.
Marta Gargantilla, José López-Fernández, Maria-Jose Camarasa, Leentje Persoons, Dirk Daelemans, Eva-Maria Priego, María-Jesús Pérez-Pérez   +6 more
doaj   +1 more source

Effects of cadmium on osteoblast cell line: Exportin 1 accumulation, p-JNK activation, DNA damage and cell apoptosis

Ecotoxicology and Environmental Safety, 2021
Cadmium is an environmental metal pollutant that has been a focus of research in recent years, which is reported to cause bone disease; however, its skeletal toxicity and the mechanism involved are not yet fully known. Therefore, this study used MC3T3-E1
Ling Ou, Haixia Wang, Zhidi Wu, Panpan Wang, Li Yang, Xiaoyun Li, Kehuan Sun, Xiaofeng Zhu, Ronghua Zhang   +8 more
doaj   +1 more source

Survival among patients with relapsed/refractory diffuse large B cell lymphoma treated with single-agent selinexor in the SADAL study

Journal of Hematology & Oncology, 2021
Patients with RR DLBCL who have received ≥ 2 lines of therapy have limited treatment options and an expected overall survival (OS) of 
Marie Maerevoet, Josee M. Zijlstra, George Follows, Rene-Olivier Casasnovas, J. S. P. Vermaat, Nagesh Kalakonda, Andre Goy, Sylvain Choquet, Eric Van Den Neste, Brian Hill, Catherine Thieblemont, Federica Cavallo, Fatima De la Cruz, John Kuruvilla, Nada Hamad, Ulrich Jaeger, Paolo Caimi, Ronit Gurion, Krzysztof Warzocha, Sameer Bakhshi, Juan-Manuel Sancho, Michael Schuster, Miklos Egyed, Fritz Offner, Theodoros P. Vassilakopoulos, Priyanka Samal, Matthew Ku, Xiwen Ma, Kelly Corona, Kamal Chamoun, Jatin Shah, Sharon Shacham, Michael G. Kauffman, Miguel Canales   +33 more
doaj   +1 more source

Effect of prior treatments on selinexor, bortezomib, and dexamethasone in previously treated multiple myeloma

Journal of Hematology & Oncology, 2021
Therapeutic regimens for previously treated multiple myeloma (MM) may not provide prolonged disease control and are often complicated by significant adverse events, including peripheral neuropathy.
Maria V. Mateos, Maria Gavriatopoulou, Thierry Facon, Holger W. Auner, Xavier Leleu, Roman Hájek, Meletios A. Dimopoulos, Sosana Delimpasi, Maryana Simonova, Ivan Špička, Ludĕk Pour, Iryna Kriachok, Halyna Pylypenko, Vadim Doronin, Ganna Usenko, Reuben Benjamin, Tuphan K. Dolai, Dinesh K. Sinha, Christopher P. Venner, Mamta Garg, Don A. Stevens, Hang Quach, Sundar Jagannath, Philippe Moreau, Moshe Levy, Ashraf Z. Badros, Larry D. Anderson, Nizar J. Bahlis, Michele Cavo, Yi Chai, Jacqueline Jeha, Melina Arazy, Jatin Shah, Sharon Shacham, Michael G. Kauffman, Paul G. Richardson, Sebastian Grosicki   +36 more
doaj   +1 more source

XPO1 inhibition with selinexor synergizes with proteasome inhibition in neuroblastoma by targeting nuclear export of IkB

Translational Oncology, 2021
Across many cancer types in adults, upregulation of the nuclear-to-cytoplasmic transport protein Exportin-1 (XPO1) correlates with poor outcome and responsiveness to selinexor, an FDA-approved XPO1 inhibitor.
Basia Galinski, Marcus Luxemburg, Yosef Landesman, Bruce Pawel, Katherine J. Johnson, Stephen R. Master, Kevin W. Freeman, David M. Loeb, Jean M. Hébert, Daniel A. Weiser   +9 more
doaj   +1 more source

The nuclear export receptor OsXPO1 is required for rice development and involved in abiotic stress responses

Crop Journal, 2023
The transport of proteins to and from the nucleus is necessary for many cellular processes and is one of the ways plants respond to developmental signals and environmental stresses.
Qiufei Peng, Jieyu Qiu, Xintong Li, Xuezhong Xu, Xinxiang Peng, Guohui Zhu   +5 more
doaj   +1 more source

XPO1 (exportin 1 (CRM1 homolog, yeast)) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012
Review on XPO1 (exportin 1 (CRM1 homolog, yeast)), with data on DNA, on the protein encoded, and where the gene is implicated.
Ruggiero A, Giubettini M, Lavia P
openaire   +4 more sources

Orientia tsutsugamushi uses two Ank effectors to modulate NF-κB p65 nuclear transport and inhibit NF-κB transcriptional activation.

PLoS Pathogens, 2018
Orientia tsutsugamushi causes scrub typhus, a potentially fatal infection that threatens over one billion people. Nuclear translocation of the transcription factor, NF-κB, is the central initiating cellular event in the antimicrobial response.
Sean M Evans, Kyle G Rodino, Haley E Adcox, Jason A Carlyon   +3 more
doaj   +1 more source

Loss of p53 expression in cancer cells alters cell cycle response after inhibition of exportin-1 but does not prevent cell death [PDF]

Cell Cycle, 2018
James D. Orth
exaly   +2 more sources

Structural determinants of nuclear export signal orientation in binding to exportin CRM1

eLife, 2015
The Chromosome Region of Maintenance 1 (CRM1) protein mediates nuclear export of hundreds of proteins through recognition of their nuclear export signals (NESs), which are highly variable in sequence and structure.
Ho Yee Joyce Fung, Szu-Chin Fu, Chad A Brautigam, Yuh Min Chook   +3 more
doaj   +1 more source