Specific inhibition of the nuclear exporter exportin-1 attenuates kidney cancer growth. [PDF]
PLoS ONE, 2014 PurposeDespite the advent of FDA-approved therapeutics to a limited number of available targets (kinases and mTOR), PFS of kidney cancer (RCC) has been extended only one to two years due to the development of drug resistance.
Hiromi I Wettersten +5 more
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Exportin 1‐mediated nuclear/cytoplasmic trafficking controls drug sensitivity of classical Hodgkin's lymphoma [PDF]
Molecular Oncology, 2023 Exportin 1 (XPO1) is the main nuclear export receptor that controls the subcellular trafficking and the functions of major regulatory proteins. XPO1 is overexpressed in various cancers and small inhibitors of nuclear export (SINEs) have been developed to
Mélody Caillot +10 more
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Exportin 1 inhibition as antiviral therapy. [PDF]
Drug Discov Today, 2020 Coronavirus 2019 (COVID-19; caused by Severe Acute Respiratory Syndrome Coronavirus 2; SARS-CoV-2) is a currently global health problem. Previous studies showed that blocking nucleocytoplasmic transport with exportin 1 (XPO1) inhibitors originally developed as anticancer drugs can quarantine key viral accessory proteins and genomic materials in the ...
Uddin MH, Zonder JA, Azmi AS.
europepmc +3 more sources
Targeting of nucleo‑cytoplasmic transport factor exportin 1 in malignancy (Review). [PDF]
Med Int (Lond), 2022 Nuclear pore complexes (NPCs) regulate the entry and exit of molecules from the cell nucleus. Small molecules pass through NPCs by diffusion while large molecules enter and exit the nucleus by karyopherins, which serve as transport factors. Exportin-1 (XPO1) is a protein that is an important member of the karyopherin family and carries macromolecules ...
Özdaş S, Canatar İ.
europepmc +4 more sources
Therapeutic targeting of exportin-1 beyond nuclear export. [PDF]
Trends Pharmacol SciExportin-1 (XPO1), also known as chromosome region maintenance 1 (CRM1), directly binds to and mediates the nuclear export of hundreds of cargo proteins. Blocking nuclear export by the selective inhibitors of nuclear export (SINEs) is a validated therapeutic axis in cancer and an active area of research.
Chen YF, Adams DJ.
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P006 (0037) RECURRENT EXPORTIN 1 MUTATIONS IN PATIENTS WITH CLASSICAL HODGKIN LYMPHOMA [PDF]
HemaSphere, 2018 doaj +3 more sources
Exportin 1 (Crm1p) Is an Essential Nuclear Export Factor [PDF]
Cell, 1997 Nuclear protein export is mediated by nuclear export signals (NESs), but the mechanisms governing this transport process are not well understood. Using a novel protein export assay in S. cerevisiae, we identify CRM1 as an essential mediator of nuclear protein export in yeast.
Stade, Katrin +3 more
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XPO1E571K Mutation Modifies Exportin 1 Localisation and Interactome in B-cell Lymphoma. [PDF]
Cancers (Basel), 2020 The XPO1 gene encodes exportin 1 (XPO1) that controls the nuclear export of cargo proteins and RNAs. Almost 25% of primary mediastinal B-cell lymphoma (PMBL) and classical Hodgkin lymphoma (cHL) cases harboured a recurrent XPO1 point mutation (NM_003400, chr2:g61718472C>T) resulting in the E571K substitution within the hydrophobic groove of the ...
Miloudi H +9 more
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Leptomycin B alters the subcellular distribution of CRM1 (Exportin 1). [PDF]
Biochem Biophys Res Commun, 2017 CRM1 (chromosome maintenance region 1, Exportin 1) binds to nuclear export signals and is required for nucleocytoplasmic transport of a large variety of proteins and RNP complexes. Leptomycin B (LMB), the first specific inhibitor of CRM1 identified, binds covalently to cysteine 528 in the nuclear export signal binding region of CRM1 leading to the ...
Rahmani K, Dean DA.
europepmc +4 more sources
Exportin 1 (XPO1) Expression and Effectiveness of XPO1 Inhibitor Against Canine Lymphoma Cell Lines [PDF]
Veterinary SciencesLymphoma is the most common neoplasm of lymphoid tissues in dogs. Exportin 1 (XPO1) is an important major nuclear receptor for exporting proteins and RNA species.
Hardany Primarizky +4 more
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