Exportin 1 modulates life span by regulating nucleolar dynamics via the autophagy protein LGG-1/GABARAP. [PDF]
Sci Adv, 2022 Altered nucleolar and ribosomal dynamics are key hallmarks of aging, but their regulation remains unclear. Building on the knowledge that the conserved nuclear export receptor Exportin 1 (XPO-1/XPO1) modulates proteostasis and life span, we ...
Kumar AV +6 more
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Verdinexor, a Selective Inhibitor of Nuclear Exportin 1, Inhibits the Proliferation and Migration of Esophageal Cancer via XPO1/c-Myc/FOSL1 Axis. [PDF]
Int J Biol Sci, 2022 Esophageal carcinoma (EC) ranks sixth among cancers in mortality worldwide and effective drugs to reduce EC incidence and mortality are lacking. To explore potential anti-esophageal cancer drugs, we conducted drug screening and discovered that verdinexor,
Ou L +13 more
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Validation of a non-oncogene encoded vulnerability to exportin 1 inhibition in pediatric renal tumors. [PDF]
Med, 2022 SUMMARY Background: Malignant rhabdoid tumors (MRT) and Wilms tumors (WT) are rare and aggressive renal tumors of infants and young children comprising ~ 5% of all pediatric cancers.
Coutinho DF +21 more
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Ecotoxicology and Environmental Safety, 2021 Cadmium is an environmental metal pollutant that has been a focus of research in recent years, which is reported to cause bone disease; however, its skeletal toxicity and the mechanism involved are not yet fully known. Therefore, this study used MC3T3-E1
Ling Ou +8 more
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Nuclear Exportin 1 (XPO1) Binds to the Nuclear Localization/Export Signal of the Turnip Mosaic Virus NIb to Promote Viral Infection. [PDF]
Front Microbiol, 2021 The nuclear localization signal (NLS) and nuclear export signal (NES) are key signatures of proteins for controlling nuclear import and export. The NIb protein of turnip mosaic virus (TuMV) is an RNA-dependent RNA polymerase (RdRP) that is absolutely ...
Zhang M +8 more
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CD47 interactions with exportin-1 limit the targeting of m<sup>7</sup>G-modified RNAs to extracellular vesicles. [PDF]
J Cell Commun Signal, 2022 CD47 is a marker of self and a signaling receptor for thrombospondin-1 that is also a component of extracellular vesicles (EVs) released by various cell types.
Kaur S +14 more
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Enhanced Activity of Exportin-1/CRM1 in Neurons Contributes to Autophagy Dysfunction and Senescent Features in Old Mouse Brain. [PDF]
Oxid Med Cell Longev, 2021 Brain aging is characterized by dysfunctional autophagy and cellular senescence, among other features. While autophagy can either promote or suppress cellular senescence in proliferating cells, in postmitotic cells, such as neurons, autophagy impairment ...
Gorostieta-Salas E +5 more
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P006 (0037) RECURRENT EXPORTIN 1 MUTATIONS IN PATIENTS WITH CLASSICAL HODGKIN LYMPHOMA [PDF]
HemaSphere, 2018 doaj +3 more sources
In vitro toxicity and efficacy of verdinexor, an exportin 1 inhibitor, on opportunistic viruses affecting immunocompromised individuals. [PDF]
PLoS ONE, 2018 Infection of immunocompromised individuals with normally benign opportunistic viruses is a major health burden globally. Infections with viruses such as Epstein-Barr virus (EBV), human cytomegalovirus (HCMV), Kaposi's sarcoma virus (KSHV), adenoviruses ...
Douglas G Widman +3 more
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Exportin 1 inhibition as antiviral therapy. [PDF]
Drug Discov Today, 2020 Coronavirus 2019 (COVID-19; caused by Severe Acute Respiratory Syndrome Coronavirus 2; SARS-CoV-2) is a currently global health problem. Previous studies showed that blocking nucleocytoplasmic transport with exportin 1 (XPO1) inhibitors originally developed as anticancer drugs can quarantine key viral accessory proteins and genomic materials in the ...
Uddin MH, Zonder JA, Azmi AS.
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