XPO1/Exportin-1 in Acute Myelogenous Leukemia; Biology and Therapeutic Targeting [PDF]
BiomoleculesExportin 1 is responsible for the export of hundreds of proteins, several RNA species and ribosomal components from the nucleus to the cytoplasm. Several transported proteins are important for regulation of cell proliferation and survival both in normal ...
Håkon Reikvam +2 more
exaly +9 more sources
Therapeutic Targeting of Exportin-1 in Childhood Cancer [PDF]
Cancers, 2021 Overexpression of Exportin-1 (XPO1), a key regulator of nuclear-to-cytoplasmic transport, is associated with inferior patient outcomes across a range of adult malignancies. Targeting XPO1 with selinexor has demonstrated promising results in clinical trials, leading to FDA approval of its use for multiple relapsed/refractory cancers.
Daniel Weiser +2 more
exaly +6 more sources
Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1 [PDF]
Scientific Reports, 2018 TDP-43 and FUS are nuclear proteins with multiple functions in mRNA processing. They play key roles in ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia), where they are partially lost from the nucleus and aggregate in the cytoplasm of
Helena Ederle +7 more
doaj +10 more sources
Effect of Exportin 1/XPO1 Nuclear Export Pathway Inhibition on Coronavirus Replication [PDF]
Viruses, 2023 The nucleocytoplasmic transport of proteins using XPO1 (exportin 1) plays a vital role in cell proliferation and survival. Many viruses also exploit this pathway to promote infection and replication.
Masmudur M. Rahman +8 more
doaj +5 more sources
Exportin-1-Dependent Nuclear Export of DEAD-box Helicase DDX3X is Central to its Role in Antiviral Immunity [PDF]
Cells, 2019 DEAD-box helicase 3, X-linked (DDX3X) regulates the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR)-mediated antiviral response, but can also be a host factor contributing to the replication of viruses of significance to human health, such as ...
Steven M. Heaton +5 more
doaj +5 more sources
Exportin 1 as a Therapeutic Target to Overcome Drug Resistance in Lung Cancer [PDF]
CellsNon-small cell lung cancer (NSCLC) remains the leading cause of cancer-related mortality, with therapeutic resistance continuing to limit long-term responses.
Maria Vittoria Di Marco +3 more
doaj +4 more sources
Therapeutic Potential of Exportin 1 and Aurora Kinase A Inhibition in Multiple Myeloma Cells [PDF]
Hematology ReportsBackground/Objectives: Aurora kinases (AURKs) are key regulators of mitosis, and their dysregulation contributes to plasma cell disorders, including multiple myeloma (MM) and plasma cell leukemia (PCL). Methods: The expression and prognostic relevance of
Seiichi Okabe +6 more
doaj +5 more sources
Preclinical antitumor efficacy of selective exportin 1 inhibitors in glioblastoma. [PDF]
Neuro-Oncology, 2015 Glioblastoma (GBM) is poorly responsive to current chemotherapy. The nuclear transporter exportin 1 (XPO1, CRM1) is often highly expressed in GBM, which may portend a poor prognosis. Here, we determine the efficacy of novel selective inhibitors of nuclear export (SINE) specific to XPO1 in preclinical models of GBM.Seven patient-derived GBM lines were ...
David S Knoff +2 more
exaly +5 more sources
An Exportin-1-dependent microRNA biogenesis pathway during human cell quiescence. [PDF]
Proc Natl Acad Sci U S A, 2017 Significance Quiescence is a growth-arrested cellular state; genes involved in this process are finely regulated by several factors, including miRNAs. During miRNA biogenesis, Exportin-5 transports miRNA precursors from the nucleus to the cytoplasm.
Martinez I +8 more
europepmc +5 more sources
The nuclear export protein exportin‐1 in solid malignant tumours: From biology to clinical trials [PDF]
Clinical and Translational MedicineBackground Exportin‐1 (XPO1), a crucial protein regulating nuclear‐cytoplasmic transport, is frequently overexpressed in various cancers, driving tumor progression and drug resistance. This makes XPO1 an attractive therapeutic target.
Chuanxi Lai, Lingna Xu, Sheng Dai
doaj +3 more sources