Results 11 to 20 of about 27,541,156 (167)

Therapeutic targeting of exportin-1 beyond nuclear export. [PDF]

Trends Pharmacol Sci
Exportin-1 (XPO1), also known as Chromosome Region Maintenance 1 (CRM1), directly binds to and mediates the nuclear export of hundreds of cargo proteins.
Chen YF, Adams DJ.
europepmc   +4 more sources

C646 degrades Exportin-1 to modulate p300 chromatin occupancy and function. [PDF]

Cell Chem Biol
Summary Molecular glues can induce proximity between a target protein and ubiquitin ligases to induce target degradation, but strategies for their discovery remain limited.
Chen YF, Rahman A, Sax JL, Atala Pleshinger MJ, Friedrich RM, Adams DJ.   +5 more
europepmc   +4 more sources

Therapeutic Targeting of Exportin-1 in Childhood Cancer [PDF]

Cancers, 2021
Overexpression of Exportin-1 (XPO1), a key regulator of nuclear-to-cytoplasmic transport, is associated with inferior patient outcomes across a range of adult malignancies. Targeting XPO1 with selinexor has demonstrated promising results in clinical trials, leading to FDA approval of its use for multiple relapsed/refractory cancers.
Daniel A Weiser, Thomas Alexander, Adam Green   +2 more
exaly   +5 more sources

Specific inhibition of the nuclear exporter exportin-1 attenuates kidney cancer growth. [PDF]

PLoS ONE, 2014
PurposeDespite the advent of FDA-approved therapeutics to a limited number of available targets (kinases and mTOR), PFS of kidney cancer (RCC) has been extended only one to two years due to the development of drug resistance.
Hiromi I Wettersten, Yosef Landesman, Sharon Friedlander, Sharon Shacham, Michael Kauffman, Robert H Weiss   +5 more
doaj   +7 more sources

Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1 [PDF]

Scientific Reports, 2018
TDP-43 and FUS are nuclear proteins with multiple functions in mRNA processing. They play key roles in ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia), where they are partially lost from the nucleus and aggregate in the cytoplasm of
Helena Ederle, Christina Funk, Claudia Abou-Ajram, Saskia Hutten, Eva B. E. Funk, Ralph H. Kehlenbach, Susanne M. Bailer, Dorothee Dormann   +7 more
doaj   +7 more sources

Human Exportin-1 is a Target for Combined Therapy of HIV and AIDS Related Lymphoma [PDF]

EBioMedicine, 2015
Infection with HIV ultimately leads to advanced immunodeficiency resulting in an increased incidence of cancer. For example primary effusion lymphoma (PEL) is an aggressive non-Hodgkin lymphoma with very poor prognosis that typically affects HIV infected
Eline Boons, Els Vanstreels, Maarten Jacquemyn, Tatiane C. Nogueira, Jasper E. Neggers, Thomas Vercruysse, Joost van den Oord, Sharon Tamir, Sharon Shacham, Yosef Landesman, Robert Snoeck, Christophe Pannecouque, Graciela Andrei, Dirk Daelemans   +13 more
doaj   +4 more sources

Exportin 1 inhibition prevents neuroendocrine transformation through SOX2 down-regulation in lung and prostate cancers. [PDF]

Sci Transl Med, 2023
In lung and prostate adenocarcinomas, neuroendocrine (NE) transformation to an aggressive derivative resembling small cell lung cancer (SCLC) is associated with poor prognosis.
Quintanal-Villalonga A, Durani V, Sabet A, Redin E, Kawasaki K, Shafer M, Karthaus WR, Zaidi S, Zhan YA, Manoj P, Sridhar H, Shah NS, Chow A, Bhanot UK, Linkov I, Asher M, Yu HA, Qiu J, de Stanchina E, Patel RA, Morrissey C, Haffner MC, Koche RP, Sawyers CL, Rudin CM.   +24 more
europepmc   +2 more sources

Exportin-1 functions as an adaptor for transcription factor-mediated docking of chromatin at the nuclear pore complex. [PDF]

Mol Cell
Summary Nuclear pore proteins (Nups) physically interact with hundreds of chromosomal sites, impacting transcription. In yeast, transcription factors mediate interactions between Nups and enhancers and promoters.
Ge T, Brickner DG, Zehr K, VanBelzen DJ, Zhang W, Caffalette C, Moeller GC, Ungerleider S, Marcou N, Jacob A, Nguyen VQ, Chait B, Rout MP, Brickner JH.   +13 more
europepmc   +3 more sources

Combination effect of Exportin 1 inhibitor (KPT-335) with doxorubicin or vincristine in canine lymphoma cell lines. [PDF]

J Vet Med Sci
Canine lymphoma is a common hematopoietic malignancy with limited therapeutic options, particularly in drug-resistant cases. Overexpression of Exportin 1 (XPO1) promotes oncogenesis by impairing the nuclear-cytoplasmic translocation of tumor suppressor ...
Primarizky H, Kambayashi S, Baba K, Tani K, Okuda M.   +4 more
europepmc   +2 more sources

Anti-Osteoclast Effect of Exportin-1 Inhibitor Eltanexor on Osteoporosis Depends on Nuclear Accumulation of IκBα-NF-κB p65 Complex. [PDF]

Front Pharmacol, 2022
Osteoporosis affects around 200 million people globally, with menopausal women accounting for the bulk of cases. In the occurrence and development of osteoporosis, a key role is played by osteoclasts.
Chen J, Song D, Xu Y, Wu L, Tang L, Su Y, Xie X, Zhao J, Xu J, Liu Q.   +9 more
europepmc   +2 more sources