Results 31 to 40 of about 14,810 (190)

An Exportin-1-dependent microRNA biogenesis pathway during human cell quiescence. [PDF]

Proc Natl Acad Sci U S A, 2017
Significance Quiescence is a growth-arrested cellular state; genes involved in this process are finely regulated by several factors, including miRNAs. During miRNA biogenesis, Exportin-5 transports miRNA precursors from the nucleus to the cytoplasm.
Martinez I, Hayes KE, Barr JA, Harold AD, Xie M, Bukhari SIA, Vasudevan S, Steitz JA, DiMaio D.   +8 more
europepmc   +4 more sources

C646 degrades Exportin-1 to modulate p300 chromatin occupancy and function. [PDF]

Cell Chem Biol
Molecular glues can induce proximity between a target protein and ubiquitin ligases to induce target degradation, but strategies for their discovery remain limited. We screened 3,200 bioactive small molecules and identified that C646 requires neddylation-dependent protein degradation to induce cytotoxicity.
Chen YF, Rahman A, Sax JL, Atala Pleshinger MJ, Friedrich RM, Adams DJ.   +5 more
europepmc   +3 more sources

Combined Targeting of Estrogen Receptor Alpha and Exportin 1 in Metastatic Breast Cancers. [PDF]

Cancers (Basel), 2020
The majority of breast cancer specific deaths in women with estrogen receptor positive (ER+) tumors occur due to metastases that are resistant to therapy. There is a critical need for novel therapeutic approaches to achieve tumor regression and/or maintain therapy responsiveness in metastatic ER+ tumors. The objective of this study was to elucidate the
Cotul EK, Zuo Q, Santaliz-Casiano A, Imir OB, Mogol AN, Tunc E, Duong K, Lee JK, Ramesh R, Odukoya E, Kesavadas MP, Ziogaite M, Smith BP, Mao C, Shapiro DJ, Park BH, Katzenellenbogen BS, Daly D, Aranda E, O'Neill JD, Walker C, Landesman Y, Madak-Erdogan Z.   +22 more
europepmc   +4 more sources

Cytoplasmic PML promotes TGF-β-associated epithelial–mesenchymal transition and invasion in prostate cancer [PDF]

, 2016
Epithelial–mesenchymal transition (EMT) is a key event that is involved in the invasion and dissemination of cancer cells. Although typically considered as having tumour-suppressive properties, transforming growth factor (TGF)-β signalling is altered ...
A G Pockley, A K Miles, A Kakizuka, B Terris, BR Henderson, C Gurrieri, C Johnson, CD Morrison, CH Heldin, D G Powe, D J Boocock, DG Altman, DR Principe, G Hulman, G Jin, G van Schalkwyk, H de Thé, H Son, HK Lin, J Borrow, J Hulman, J Massagué, J Massagué, JJ Christiansen, JP Thiery, Jr McCarty KS, JYH Chan, L Kubiczkova, M E Buczek, M Mazza, MG Mathieu, P Salomoni, PM Siegel, R C Rees, R Derynck, R Parkinson, RL Camp, S Grünert, S Lamouille, S Nisole, T Regad, T Regad, V Lallemand-Breitenbach, W Green, WC Yuan, Y Katakura   +45 more
core   +1 more source

Orientia tsutsugamushi uses two Ank effectors to modulate NF-κB p65 nuclear transport and inhibit NF-κB transcriptional activation.

PLoS Pathogens, 2018
Orientia tsutsugamushi causes scrub typhus, a potentially fatal infection that threatens over one billion people. Nuclear translocation of the transcription factor, NF-κB, is the central initiating cellular event in the antimicrobial response.
Sean M Evans, Kyle G Rodino, Haley E Adcox, Jason A Carlyon   +3 more
doaj   +1 more source

Structural determinants of nuclear export signal orientation in binding to exportin CRM1

eLife, 2015
The Chromosome Region of Maintenance 1 (CRM1) protein mediates nuclear export of hundreds of proteins through recognition of their nuclear export signals (NESs), which are highly variable in sequence and structure.
Ho Yee Joyce Fung, Szu-Chin Fu, Chad A Brautigam, Yuh Min Chook   +3 more
doaj   +1 more source

Pharmacological treatment with inhibitors of nuclear export enhances the antitumor activity of docetaxel in human prostate cancer [PDF]

, 2017
Background and aims: Docetaxel (DTX) modestly increases patient survival of metastatic castration-resistant prostate cancer (mCRPC) due to insurgence of pharmacological resistance. Deregulation of Chromosome Region Maintenance (CRM-1)/ exportin-1 (XPO-1)-
Argueta, Christian, BIORDI, ASSUNTA LEDA, Biordi, Leda Assunta, Colapietro, Alessandro, Festuccia, Claudio, Flati, Vincenzo, Gravina, Giovanni Luca, Iorio, Roberto, Kauffman, Michael, Landesman, Yosef, Mancini, Andrea, Marampon, Francesco, Pompili, Simona, Sferra, Roberta, Shacham, Sharon   +14 more
core   +2 more sources

Importin-beta and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function [PDF]

, 2017
Protein conjugation with small ubiquitin-related modifier (SUMO) is a post-translational modification that modulates protein interactions and localisation.
Damizia, Michela, DE SANTIS, RICCARDO, DE TURRIS, VALERIA, GILISTRO, EUGENIA, Lavia, Patrizia, MORONI, SARA, ROSA, ALESSANDRO, VERRICO, ANNALISA   +7 more
core   +1 more source

Nuclear exportin receptor CAS regulates the NPI-1-mediated nuclear import of HIV-1 Vpr. [PDF]

PLoS ONE, 2011
Vpr, an accessory protein of human immunodeficiency virus type 1, is a multifunctional protein that plays an important role in viral replication. We have previously shown that the region between residues 17 and 74 of Vpr (Vpr(N17C74)) contained a bona ...
Eri Takeda, Tomoyuki Murakami, Go Matsuda, Hironobu Murakami, Tamotsu Zako, Mizuo Maeda, Yoko Aida   +6 more
doaj   +1 more source

The evolution of core proteins involved in microRNA biogenesis

BMC Evolutionary Biology, 2008
Background MicroRNAs (miRNAs) are a recently discovered class of non-coding RNAs (ncRNAs) which play important roles in eukaryotic gene regulation. miRNA biogenesis and activation is a complex process involving multiple protein catalysts and involves the
Brown James R, Dancis Barry, Murphy Dennis   +2 more
doaj   +1 more source