Results 71 to 80 of about 15,762 (228)
Oxidative Medicine and Cellular Longevity, 2021 Brain aging is characterized by dysfunctional autophagy and cellular senescence, among other features. While autophagy can either promote or suppress cellular senescence in proliferating cells, in postmitotic cells, such as neurons, autophagy impairment ...
E. Gorostieta-Salas +5 more
semanticscholar +1 more source
Exportin-inspired artificial cell nuclear-exporting nanosystems
Nanoscale Advances, 2022 Inspired by the structural and chemical features of importin/exportin, we developed an artificial nuclear-exporting nanosystem capable of eliminating compounds accumulated abnormally in the nucleus.
Mitsuo Inui +6 more
openaire +2 more sources
Representation of Exportin-5 orthologs annotations.
, 2014 Common terms between species are displayed in blue. The terms annotating only the human ortholog are displayed in red. Part A of this figure displays the MF annotations of the human and rat orthologs of Exportin-5.
Charles Bettembourg (116573) +2 more
core +1 more source
The mouse KLF1 Nan variant impairs nuclear condensation and erythroid maturation.
PLoS ONE, 2019 Krüppel-like factor 1 (KLF1) is an essential transcription factor for erythroid development, as demonstrated by Klf1 knockout mice which die around E14 due to severe anemia. In humans, >140 KLF1 variants, causing different erythroid phenotypes, have been
Ileana Cantú +12 more
doaj +1 more source
Romanian Journal of Internal Medicine, 2023 Venous thromboembolism (VTE) is the third most common hemostatic disease worldwide. Studies have reported a role for microRNA (miRNA) in the homeostasis and development of VTE.
Alquraan Khloud M., Khabour Omar F.
doaj +1 more source
The nuclear export protein exportin‐1 in solid malignant tumours: From biology to clinical trials
Clinical and Translational MedicineBackground Exportin‐1 (XPO1), a crucial protein regulating nuclear‐cytoplasmic transport, is frequently overexpressed in various cancers, driving tumor progression and drug resistance. This makes XPO1 an attractive therapeutic target.
Chuan-Xi Lai, Ling-Na Xu, Sheng Dai
semanticscholar +1 more source
PAUSEDEncodes the Arabidopsis Exportin-t Ortholog [PDF]
Plant Physiology, 2003 AbstractLos1p/exportin-t (XPOT) mediates the nuclear export of tRNAs in yeast and mammals. The requirements for this transport pathway are unclear, however, because los1 mutations do not affect yeast growth, and the phenotype of XPOT mutations in mammals is unknown. Here, we show that PAUSED (PSD) is the Arabidopsis ortholog of LOS1/XPOT and is capable
Christine A, Hunter +4 more
openaire +2 more sources
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
Export of piRNA precursors by EJC triggers assembly of cytoplasmic Yb-body in Drosophila
Nature Communications, 2016 In Drosophila ovarian follicle cells, piRNAs generated from RNA precursors are processed in cytoplasmic Yb-bodies. The authors identify the exportin and the exon junction complexes as required to transfer precursors to cytoplasm.
Cynthia Dennis +3 more
doaj +1 more source
Journal of Hematology & Oncology, 2021 Patients with RR DLBCL who have received ≥ 2 lines of therapy have limited treatment options and an expected overall survival (OS) of
Marie Maerevoet +33 more
doaj +1 more source