Results 51 to 60 of about 15,762 (228)

Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs.

Genes & Development, 2003
MicroRNAs (miRNAs) are initially expressed as long transcripts that are processed in the nucleus to yield approximately 65-nucleotide (nt) RNA hairpin intermediates, termed pre-miRNAs, that are exported to the cytoplasm for additional processing to yield
R. Yi, Yi Qin, I. Macara, B. Cullen
semanticscholar   +1 more source

Exportins can inhibit major mitotic assembly events in vitro: membrane fusion, nuclear pore formation, and spindle assembly

Nucleus, 2020
Xenopus egg extracts are a powerful in vitro tool for studying complex biological processes, including nuclear reconstitution, nuclear membrane and pore assembly, and spindle assembly.
Matthew S. Nord, Cyril Bernis, Sarah Carmona, Dennis C. Garland, Anna Travesa, Douglass J. Forbes   +5 more
doaj   +1 more source

Verdinexor, a Selective Inhibitor of Nuclear Exportin 1, Inhibits the Proliferation and Migration of Esophageal Cancer via XPO1/c-Myc/FOSL1 Axis

International Journal on Biological Sciences, 2022
Esophageal carcinoma (EC) ranks sixth among cancers in mortality worldwide and effective drugs to reduce EC incidence and mortality are lacking. To explore potential anti-esophageal cancer drugs, we conducted drug screening and discovered that verdinexor,
Ling Ou, Xinyou Wang, Shu-Min Cheng, M. Zhang, Ruiqin Cui, Chunyan Hu, Shiyi Liu, Qian Tang, Yuying Peng, Ruihuan Chai, Shou-Xia Xie, Shao-Xiang Wang, Wei Huang, Xiao Wang   +13 more
semanticscholar   +1 more source

Controlling the Gatekeeper: Therapeutic Targeting of Nuclear Transport

Cells, 2018
Nuclear transport receptors of the karyopherin superfamily of proteins transport macromolecules from one compartment to the other and are critical for both cell physiology and pathophysiology.
Friederike K. Kosyna, Reinhard Depping
doaj   +1 more source

Validation of a non-oncogene encoded vulnerability to Exportin 1 inhibition in pediatric renal tumors

i Medicina, 2022
SUMMARY Background: Malignant rhabdoid tumors (MRT) and Wilms tumors (WT) are rare and aggressive renal tumors of infants and young children comprising ~ 5% of all pediatric cancers.
D. Coutinho, P. Mundi, Lianna J. Marks, Chelsey M. Burke, M. Ortiz, Daniel Diolaiti, Lauren E. Bird, K. Vallance, G. Ibanez, Dao-Qi You, Matthew Long, N. Rosales, A. Grunn, A. Ndengu, Armaan Siddiquee, Ervin S. Gaviria, Allison R. Rainey, Ladan Fazlollahi, H. Hosoi, A. Califano, A. Kung, F. D. Dela Cruz   +21 more
semanticscholar   +1 more source

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning

eLife, 2015
CRM1 is a highly conserved, RanGTPase-driven exportin that carries proteins and RNPs from the nucleus to the cytoplasm. We now explored the cargo-spectrum of CRM1 in depth and identified surprisingly large numbers, namely >700 export substrates from ...
Koray Kırlı, Samir Karaca, Heinz Jürgen Dehne, Matthias Samwer, Kuan Ting Pan, Christof Lenz, Henning Urlaub, Dirk Görlich   +7 more
doaj   +1 more source

Exportin Crm1 is repurposed as a docking protein to generate microtubule organizing centers at the nuclear pore

eLife, 2018
Non-centrosomal microtubule organizing centers (MTOCs) are important for microtubule organization in many cell types. In fission yeast Schizosaccharomyces pombe, the protein Mto1, together with partner protein Mto2 (Mto1/2 complex), recruits the γ ...
Xun X Bao, Christos Spanos, Tomoko Kojidani, Eric M Lynch, Juri Rappsilber, Yasushi Hiraoka, Tokuko Haraguchi, Kenneth E Sawin   +7 more
doaj   +1 more source

Exportin 1 modulates life span by regulating nucleolar dynamics via the autophagy protein LGG-1/GABARAP

Science Advances, 2022
Altered nucleolar and ribosomal dynamics are key hallmarks of aging, but their regulation remains unclear. Building on the knowledge that the conserved nuclear export receptor Exportin 1 (XPO-1/XPO1) modulates proteostasis and life span, we ...
Anita V. Kumar, Taewook Kang, Tara G. Thakurta, Celeste Ng, Aric N. Rogers, M. Larsen, L. R. Lapierre   +6 more
semanticscholar   +1 more source

Exportin-4 coordinates nuclear shuttling of TOPLESS family transcription corepressors to regulate plant immunity.

The Plant Cell, 2021
The regulated nucleocytoplasmic exchange of macromolecules is essential for the eukaryotic cell. However, nuclear transport pathways defined by different nuclear transport receptors (NTRs), including importins and exportins, and their significance in ...
Feifei Xu, Min Jia, Xin Li, Yu Tang, K. Jiang, J. Bao, Yangnan Gu   +6 more
semanticscholar   +1 more source

Anti-Osteoclast Effect of Exportin-1 Inhibitor Eltanexor on Osteoporosis Depends on Nuclear Accumulation of IκBα–NF-κB p65 Complex

Frontiers in Pharmacology, 2022
Osteoporosis affects around 200 million people globally, with menopausal women accounting for the bulk of cases. In the occurrence and development of osteoporosis, a key role is played by osteoclasts.
Junchun Chen, Dezhi Song, Yang Xu, Liwei Wu, Lili Tang, Yuangang Su, Xiaoxiao Xie, Jinmin Zhao, Jia-Ke Xu, Qian Liu   +9 more
semanticscholar   +1 more source