Results 41 to 50 of about 15,762 (228)

Exportin 1 (Crm1p) Is an Essential Nuclear Export Factor [PDF]

Cell, 1997
Nuclear protein export is mediated by nuclear export signals (NESs), but the mechanisms governing this transport process are not well understood. Using a novel protein export assay in S.
Ford, Charleen S., Guthrie, Christine, Stade, Katrin, Weis, Karsten   +3 more
core   +4 more sources

Understanding Exportin-1 as an Anti-Cancer Target [PDF]

, 2018
Exportin-1 is a promising new anti-cancer target for selective inhibitors of nuclear export (SINE) molecules. Selinexor is a first-in-class SINE molecule in clinical trials for a variety of different cancers. Selinexor and other SINE molecules covalently
Burke, Russell Thomas
core   +8 more sources

Re-evaluation of the roles of DROSHA, Exportin 5, and DICER in microRNA biogenesis

Proceedings of the National Academy of Sciences of the United States of America, 2016
Young-Kook Kim, Vic Narry Kim, Boseon Kim   +2 more
exaly   +2 more sources

How SARS-CoV-2 and Other Viruses Build an Invasion Route to Hijack the Host Nucleocytoplasmic Trafficking System

Cells, 2021
The host nucleocytoplasmic trafficking system is often hijacked by viruses to accomplish their replication and to suppress the host immune response.
Elma Sakinatus Sajidah, Keesiang Lim, Richard W. Wong   +2 more
doaj   +1 more source

Leptin-Responsive MiR-4443 Is a Small Regulatory RNA Independent of the Canonic MicroRNA Biogenesis Pathway

Biomolecules, 2020
The human small RNA miR-4443 is functionally involved in several types of cancer and in the biology of the immune system, downstream of insulin and leptin signaling.
Ari Meerson
doaj   +1 more source

Immunohistochemical expression of Drosha is reduced in eutopic and ectopic endometrium of women with adenomyosis

Brazilian Journal of Medical and Biological Research, 2022
The objective of this study was to evaluate the immunohistochemical expression of Dicer, Drosha, and Exportin-5 in the eutopic and ectopic endometrium of women with adenomyosis.
I. Ormenezi, A. Ribeiro-Silva, J.C. Rosa-e-Silva, J. Meola, F.J. Candido-dos-Reis, O.B. Poli-Neto   +5 more
doaj   +1 more source

Importins and exportins in cellular differentiation [PDF]

Journal of Cellular and Molecular Medicine, 2008
Introduction Importins and exportins NLS and NES Cargo molecules Importins and exportins In cellular differentiation Concluding remarks AbstractThe importin/exportin transport system provides the machinery involved in nucleocytoplasmic transport.
Okada, Norihisa, Ishigami, Yoko, Suzuki, Takuji, Kaneko, Akihiro, Yasui, Kensuke, Fukutomi, Ryuuta, Isemura, Mamoru   +6 more
openaire   +2 more sources

Rescue of Mitochondrial Function in Hutchinson-Gilford Progeria Syndrome by the Pharmacological Modulation of Exportin CRM1

Cells, 2023
Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder caused by the expression of progerin, a mutant variant of Lamin A. Recently, HGPS studies have gained relevance because unraveling its underlying mechanism would help to ...
Feliciano Monterrubio-Ledezma, F. Navarro-García, L. Massieu, R. Mondragón-Flores, Luz Adriana Soto-Ponce, J. J. Magaña, B. Cisneros   +6 more
semanticscholar   +1 more source

Differential interactome mapping of aggregation prone/prion-like proteins under stress: novel links to stress granule biology

Cell & Bioscience, 2023
Background Aberrant stress granules (SGs) are emerging as prime suspects in the nucleation of toxic protein aggregates. Understanding the molecular networks linked with aggregation-prone proteins (prion protein, synuclein, and tau) under stressful ...
Neelam Younas, Saima Zafar, Tayyaba Saleem, Leticia Camila Fernandez Flores, Abrar Younas, Matthias Schmitz, Inga Zerr   +6 more
doaj   +1 more source

A highly potent small-molecule antagonist of exportin-1 selectively eliminates CD44+CD24- enriched breast cancer stem-like cells.

Drug resistance updates, 2022
Breast cancer stem-like cells (BCSCs) have been suggested as the underlying cause of tumor recurrence, metastasis and drug resistance in triple-negative breast cancer (TNBC).
Cai-Gang Liu, Yixiao Zhang, Jiujiao Gao, Qi Zhang, Lisha Sun, Qingtian Ma, X. Qiao, Xinnan Li, Jin-Chi Liu, Jia-Wen Bu, Zhan Zhang, Ling Han, Dongyu Zhao, Yongliang Yang   +13 more
semanticscholar   +1 more source