Key role of exportin 6 in exosome-mediated viral transmission from insect vectors to plants
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance Exosomes are a type of membranous extracellular vesicle and have been highlighted for their various roles in the transmission of microorganisms. Exportins are frequently found in exosomes.
Feng Cui, Qiong Li
exaly +2 more sources
Phosphate-dependent nuclear export via a non-classical NES class recognized by exportin Msn5
Nature CommunicationsGene expression in response to environmental stimuli is dependent on nuclear localization of key signaling components, which can be tightly regulated by phosphorylation.
Ho Yee Joyce Fung +8 more
doaj +2 more sources
Expression and function of exportin 6 in full-grown and growing porcine oocytes
Journal of Reproduction and Development, 2019 Exportin 6, which functions specifically in the nuclear export of actin family proteins, has been reported to be absent in immature Xenopus oocytes, which have a huge nucleus containing a large amount of actin. In mammalian oocytes, however, the presence
Koji Sugiura +2 more
exaly +3 more sources
Ecotoxicology and Environmental Safety, 2021 Cadmium is an environmental metal pollutant that has been a focus of research in recent years, which is reported to cause bone disease; however, its skeletal toxicity and the mechanism involved are not yet fully known. Therefore, this study used MC3T3-E1
Ling Ou +8 more
doaj +2 more sources
Exportin-5 orthologues are functionally divergent among species [PDF]
Nucleic Acids Research, 2006 Exportin-5, an evolutionarily conserved nuclear export factor belonging to the importin-b family of proteins, is known to play a role in the nuclear export of small noncoding RNAs such as precursors of microRNA, viral minihelix RNA and a subset of tRNAs ...
Yoshihiro Yoneda +6 more
core +3 more sources
Exportin-5 mediates nuclear export of minihelix-containing RNAs [PDF]
Journal of Biological Chemistry, 2003 International audienceThe adenovirus VA1 RNA (VA1.), a 160-nucleotide (nt)- long RNA transcribed by RNA polymerase III, is efficiently exported from the nucleus to the cytoplasm of infected cells, where it antagonizes the interferon-induced antiviral ...
Alain Doglio +13 more
core +5 more sources
Phytophthora capsici carries and differentially expresses genes for the RNA interference pathway. [PDF]
PLoS ONEThe RNA interference (RNAi) pathway is an epigenetic mechanism that has recently gained attention for its role in regulating the virulence of plant pathogens.
Jacobo Sevillano-Serrano +5 more
doaj +2 more sources
Targeting nuclear export and Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) signalling in myelofibrosis: A novel combinatorial strategy that impacts intrinsic and microenvironment-related pathways. [PDF]
Br J HaematolSelinexor targets molecular pathways critical to myelofibrosis (MF) progenitor cell fitness and demonstrates complementary activity with ruxolitinib, supporting its potential as a novel disease‐modifying therapeutic strategy for MF. Summary Myelofibrosis (MF) is a chronic myeloproliferative neoplasm (MPN) characterized by splenomegaly, constitutional ...
Kashyap T +7 more
europepmc +2 more sources
Small-molecule antagonist targeting exportin-1 via rational structure-based discovery.
Journal of Medicinal Chemistry, 2020 Exportin-1 (also named as CRM1) plays a prominent role in autoimmune disorders and has emerged as a potential therapeutic target for colitis. Here we report on the rational structure-based discovery of a small-molecule antagonist of exportin-1, LFS-829 ...
Xibao Tian +16 more
semanticscholar +3 more sources
Cells, 2019 DEAD-box helicase 3, X-linked (DDX3X) regulates the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR)-mediated antiviral response, but can also be a host factor contributing to the replication of viruses of significance to human health, such as ...
Steven M. Heaton +5 more
doaj +2 more sources