Results 11 to 20 of about 15,762 (228)
XPO1/Exportin-1 in Acute Myelogenous Leukemia; Biology and Therapeutic Targeting [PDF]
BiomoleculesExportin 1 is responsible for the export of hundreds of proteins, several RNA species and ribosomal components from the nucleus to the cytoplasm. Several transported proteins are important for regulation of cell proliferation and survival both in normal ...
Håkon Reikvam +2 more
exaly +6 more sources
Multiomics Analysis of Exportin Family Reveals XPO1 as a Novel Target for Clear Cell Renal Cell Carcinoma [PDF]
International Journal of GenomicsConclusion: This study analyzed the variations of exportin gene family members at the pan-cancer level and identified two distinct ccRCC subtypes, which can guide personalized management of patients.
Aimin Jiang
exaly +4 more sources
The Role of Exportin-5 in MicroRNA Biogenesis and Cancer
Genomics, Proteomics & Bioinformatics, 2018 MicroRNAs (miRNAs) are conserved small non-coding RNAs that play an important role in the regulation of gene expression and participate in a variety of biological processes.
Ke Wu, Juan He, Wenchen Pu, Yong Peng
doaj +6 more sources
Cancer-associated exportin-6 upregulation inhibits the transcriptionally repressive and anticancer effects of nuclear profilin-1 [PDF]
Cell Reports, 2021 SUMMARY Aberrant expression of nuclear transporters and deregulated subcellular localization of their cargo proteins are emerging as drivers and therapeutic targets of cancer.
Cuige Zhu, Jason M. Held, Eugene M Oltz
exaly +3 more sources
Exportin 4 DNA promoter methylation in liver fibrosis
PLoS ONEA role for exportin 4 (XPO4) in the pathogenesis of liver fibrosis was recently identified. We sought to determine changes in hepatic XPO4 promoter methylation levels during liver fibrosis. The quantitative real-time RT-PCR technique was used to quantify
Ziyan Pan +4 more
doaj +5 more sources
Selectivity of Exportin 5 binding to human precursor microRNAs
RNA Biology, 2021 Exportin 5 (Exp5, XPO5) is a nuclear export factor that functions in the microRNA (miRNA) biogenesis pathway to transport precursor miRNAs (pre-miRNAs) from the nucleus to the cytoplasm.
Xiao-Xiao Zhang +4 more
semanticscholar +4 more sources
Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1 [PDF]
Scientific Reports, 2018 TDP-43 and FUS are nuclear proteins with multiple functions in mRNA processing. They play key roles in ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia), where they are partially lost from the nucleus and aggregate in the cytoplasm of
Helena Ederle +7 more
doaj +3 more sources
Exportin T and Exportin 5: tRNA and miRNA biogenesis - and beyond [PDF]
bchm, 2012 The biogenesis of most eukaryotic kinds of RNA requires nuclear export, which is mediated by a variety of specific nuclear transport receptors. The nuclear export receptors Exportin-t (Exp-t) and Exportin 5 (Exp5), and their homologues, are involved in ...
Martin, Roman +3 more
core +3 more sources
Exportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs
Nature Communications, 2022 This study identifies the evolutionarily conserved Exportin 4 as an essential regulator in the nuclear export of circRNAs. Defective circRNA export results in R-loop formation and DNA damage in cells, as well as testis and neurological defects in mice.
Liang Chen +29 more
doaj +2 more sources
Science Translational Medicine, 2023 In lung and prostate adenocarcinomas, neuroendocrine (NE) transformation to an aggressive derivative resembling small cell lung cancer (SCLC) is associated with poor prognosis.
Á. Quintanal-Villalonga +24 more
semanticscholar +2 more sources