Results 31 to 40 of about 15,762 (228)

CD47 interactions with exportin-1 limit the targeting of m7G-modified RNAs to extracellular vesicles

Journal of Cell Communication and Signaling, 2021
CD47 is a marker of self and a signaling receptor for thrombospondin-1 that is also a component of extracellular vesicles (EVs) released by various cell types.
Joshua Zimmerberg, Abdel G Elkahloun, David D Roberts   +2 more
exaly   +2 more sources

Mechanism of exportin retention in the cell nucleus

Journal of Cell Biology
Proteins function within specific locations of the cell. Oftentimes their mislocalization is associated with disease. Here, we delineate a retention mechanism at nuclear pore complexes that enriches nuclear transport receptors in the nucleus to export ...
L. Kapinos, Joanna Kalita, Elena Kassianidou, C. Rencurel, Roderick Y. H. Lim   +4 more
semanticscholar   +3 more sources

Exportin-mediated nucleocytoplasmic transport maintains Pch2 homeostasis during meiosis.

PLoS Genetics, 2023
The meiotic recombination checkpoint reinforces the order of events during meiotic prophase I, ensuring the accurate distribution of chromosomes to the gametes.
Esther Herruzo, Estefanía Sánchez-Díaz, Sara González-Arranz, Beatriz Santos, Jesús A Carballo, Pedro A San-Segundo   +5 more
doaj   +2 more sources

Exportin 1‐mediated nuclear/cytoplasmic trafficking controls drug sensitivity of classical Hodgkin's lymphoma

Molecular Oncology, 2023
Exportin 1 (XPO1) is the main nuclear export receptor that controls the subcellular trafficking and the functions of major regulatory proteins. XPO1 is overexpressed in various cancers and small inhibitors of nuclear export (SINEs) have been developed to
Mélody Caillot, Hadjer Miloudi, Antoine Taly, Nuria Profitós‐Pelejà, Juliana C. Santos, Marcelo L. Ribeiro, Elsa Maitre, Simon Saule, Gaël Roué, Fabrice Jardin, Brigitte Sola   +10 more
doaj   +2 more sources

Xpo7 is a broad-spectrum exportin and a nuclear import receptor. [PDF]

Journal of Cell Biology, 2018
Exportins bind cargo molecules in a RanGTP-dependent manner inside nuclei and transport them through nuclear pores to the cytoplasm. CRM1/Xpo1 is the best-characterized exportin because specific inhibitors such as leptomycin B allow straightforward cargo
Karaca, Samir, Henning Urlaub, Seibel, K., Aksu, Metin, Aksu, M., Urlaub, Henning, Kappert, Christin, Katharina Seibel, Samir Karaca, Christin Kappert, Bohnsack, Markus T., Pleiner, T., Dehne, H., Seibel, Katharina, Bohnsack, M., Markus T. Bohnsack, Heinz-Jürgen Dehne, Görlich, D., Pleiner, Tino, Tino Pleiner, Kappert, C., Urlaub, H., Dirk Görlich, Metin Aksu, Görlich, Dirk, Dehne, Heinz-Jürgen, Karaca, S.   +26 more
core   +8 more sources

Exportin 1 inhibition as antiviral therapy

Drug Discovery Today, 2020
Highlights • Nucleo-cytoplasmic transport is crucial for the proper functioning of cells.• Studies targeting nucleo-cytoplasmic transport have chiefly focused on cancer.• XPO1 mediated protein or RNA export is necessary for viral replication.• XPO1 ...
M. H. Uddin, J. Zonder, A. Azmi
semanticscholar   +3 more sources

Strukturelle und funktionelle Analyse der Exportin-Kargo-Erkennung [PDF]

, 2010
Jeglicher Stoffaustausch zwischen Zellkern und Zellplasma verläuft über sogenannte Kernporenkomplexe gigantische in die Kernhülle eingebettete Kanäle.
Güttler, Thomas
core   +4 more sources

Therapeutic Targeting of Exportin-1 Beyond Nuclear Export

Trends in Pharmacological Sciences
Exportin-1 (XPO1), also known as Chromosome Region Maintenance 1 (CRM1), directly binds to and mediates the nuclear export of hundreds of cargo proteins.
Yi-Fan Chen, Drew J. Adams
semanticscholar   +3 more sources

Structural Basis of Targeting the Exportin CRM1 in Cancer [PDF]

Cells, 2015
Recent studies have demonstrated the interference of nucleocytoplasmic trafficking with the establishment and maintenance of various cancers. Nucleocytoplasmic transport is highly regulated and coordinated, involving different nuclear transport factors ...
Achim Dickmanns, Thomas Monecke, Ralf Ficner   +2 more
doaj   +4 more sources

Effect of Exportin 1/XPO1 Nuclear Export Pathway Inhibition on Coronavirus Replication

Viruses
The nucleocytoplasmic transport of proteins using XPO1 (exportin 1) plays a vital role in cell proliferation and survival. Many viruses also exploit this pathway to promote infection and replication.
Masmudur M. Rahman, Bereket Estifanos, Honor L. Glenn, Ami D. Gutierrez-Jensen, Karen Kibler, Yize Li, Bertram Jacobs, Grant McFadden, Brenda G. Hogue   +8 more
doaj   +2 more sources