Results 61 to 70 of about 15,762 (228)

Viruses Challenge Selectivity Barrier of Nuclear Pores

Viruses, 2013
Exchange between the nucleus and the cytoplasm occurs through nuclear pore complexes (NPCs) embedded in the double membrane of the nuclear envelope. NPC permeability barrier restricts the entry of inert molecules larger than 5 nm in diameter but allows ...
Ariberto Fassati, Aksana A. Labokha
doaj   +1 more source

Importin/exportin-mediated nucleocytoplasmic shuttling of cucumber mosaic virus 2b protein is required for 2b’s efficient suppression of RNA silencing

PLoS Pathogens, 2022
The 2b protein (2b) of cucumber mosaic virus (CMV), an RNA-silencing suppressor (RSS), is a major pathogenicity determinant of CMV. 2b is localized in the nucleus and cytoplasm, and its nuclear import is determined by two nuclear localization signals ...
Hangil Kim, H. Shimura, K. Sueda, C. Masuta   +3 more
semanticscholar   +1 more source

Orientia tsutsugamushi uses two Ank effectors to modulate NF-κB p65 nuclear transport and inhibit NF-κB transcriptional activation.

PLoS Pathogens, 2018
Orientia tsutsugamushi causes scrub typhus, a potentially fatal infection that threatens over one billion people. Nuclear translocation of the transcription factor, NF-κB, is the central initiating cellular event in the antimicrobial response.
Sean M Evans, Kyle G Rodino, Haley E Adcox, Jason A Carlyon   +3 more
doaj   +1 more source

Nucleo-Cytoplasmic Transport of ZIKV Non-Structural 3 Protein Is Mediated by Importin-α/β and Exportin CRM-1

Journal of Virology, 2022
Flaviviruses have a cytoplasmic replication cycle, but recent evidence indicates that nuclear elements play a role in their viral replication. Viral proteins, such as NS5 and C, are imported into the nucleus, and blocking their import prevents ...
L. A. de Jesús-González, S. Palacios-Rápalo, J. Reyes-Ruíz, J. F. Osuna-Ramos, C. N. Farfán-Morales, C. D. Cordero-Rivera, B. Cisneros, A. Gutiérrez-Escolano, R. D. del Ángel   +8 more
semanticscholar   +1 more source

The evolution of core proteins involved in microRNA biogenesis

BMC Evolutionary Biology, 2008
Background MicroRNAs (miRNAs) are a recently discovered class of non-coding RNAs (ncRNAs) which play important roles in eukaryotic gene regulation. miRNA biogenesis and activation is a complex process involving multiple protein catalysts and involves the
Brown James R, Dancis Barry, Murphy Dennis   +2 more
doaj   +1 more source

Nuclear Exportin 1 (XPO1) Binds to the Nuclear Localization/Export Signal of the Turnip Mosaic Virus NIb to Promote Viral Infection

Frontiers in Microbiology, 2022
The nuclear localization signal (NLS) and nuclear export signal (NES) are key signatures of proteins for controlling nuclear import and export. The NIb protein of turnip mosaic virus (TuMV) is an RNA-dependent RNA polymerase (RdRP) that is absolutely ...
Ming-Zhen Zhang, Pan Gong, Lin-Hao Ge, Yin-Zi Li, Zhao-Yang Chang, Rui Qiao, Xueping Zhou, Ai-Ming Wang, Fangfang Li   +8 more
semanticscholar   +1 more source

Nuclear Export Receptors: From Importin to Exportin [PDF]

Cell, 1997
In a literal sense, export receptors may next interact with proteins of the nuclear pore (for example,Powers et al. 1997xPowers, M.A., Forbes, D.J., Dahlberg, J.E., and Lund, E. J. Cell Biol. 1997; 136: 241–250Crossref | PubMed | Scopus (152)See all ReferencesPowers et al. 1997; see alsoDoye and Hurt 1997xDoye, V. and Hurt, E. Curr. Opin.
Ullman, Katharine S., Powers, Maureen A., Forbes, Douglass J.   +2 more
openaire   +2 more sources

Amyotrophic Lateral Sclerosis-Associated Mutants of SOD1 Modulate miRNA Biogenesis through Aberrant Interactions with Exportin 5

ACS Chemical Biology, 2022
Mutations in the SOD1 (superoxide dismutase 1) gene are associated with amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. By employing ascorbate peroxidase-based proximity labeling, coupled with LC–MS/MS analysis, we uncovered 43 ...
Xingyuan Chen, Xiaomei He, Yen-Yu Yang, Yinsheng Wang   +3 more
semanticscholar   +1 more source

Strength in Diversity: Nuclear Export of Viral RNAs

Viruses, 2020
The nuclear export of cellular mRNAs is a complex process that requires the orchestrated participation of many proteins that are recruited during the early steps of mRNA synthesis and processing.
Jón Pol Gales, Julie Kubina, Angèle Geldreich, Maria Dimitrova   +3 more
doaj   +1 more source

Structural basis for a nucleoporin exportin complex between RanBP2, SUMO1-RanGAP1, the E2 Ubc9, Crm1 and the Ran GTPase

Nature Communications
The human nucleoporin RanBP2/Nup358 interacts with SUMO1-modified RanGAP1 and the SUMO E2 Ubc9 at the nuclear pore complex (NPC) to promote export and disassembly of exportin Crm1/Ran(GTP)/cargo complexes.
Vladimir Baytshtok, M. DiMattia, Christopher D. Lima   +2 more
semanticscholar   +1 more source