Results 121 to 130 of about 32,019,221 (177)

Preclinical characterization of a reversible XPO1 inhibitor for cancer therapy

Nature Communications
Exportin 1 (XPO1/CRM1) is a clinically validated anticancer target whose inhibition blocks nuclear export and promotes cancer cell apoptosis. Current XPO1 inhibitors rely on covalent Michael addition to Cys528 in the nuclear export signal binding groove ...
Janne Van Hauwenhuyse, Felien Reniers, Leentje Persoons, Sam Noppen, Casey E. Wing, Ashley B. Niesman, Ho Yee Joyce Fung, Els Vanstreels, Maarten Jacquemyn, Eline Boel, Ann Vankerckhoven, Yani Berckmans, Bert Kwanten, An Coosemans, Guy Van den Mooter, Yuh Min Chook, Wim Dehaen, Dirk Daelemans   +17 more
doaj   +1 more source

Exportin T and Exportin 5: tRNA and miRNA biogenesis - and beyond

, 2012
The biogenesis of most eukaryotic kinds of RNA requires nuclear export, which is mediated by a variety of specific nuclear transport receptors. The nuclear export receptors Exportin-t (Exp-t) and Exportin 5 (Exp5), and their homologues, are involved in ...
Martin, Roman, Ramirez, Ana S., Leisegang, Matthias S., Bohnsack, Markus T.   +3 more
core   +1 more source

Different Approaches For Protein Engineering In Industrial Biotechnology [PDF]

, 2011
Protein engineering is the novel field which has wide applications from pharmaceutics, industry, commercial, laundry and research. It may apply rational design or non rational design or both.
Muhammad Waheed Akhtar, Israr Khan
core  

Evaluating the effects of the nonplanarity of nucleic acid bases on NMR, IR, and vibrational circular dichroism spectra: a density functional theory computational study [PDF]

, 2010
The pyramidalizations of N9/1 glycosidic nitrogens in DNA and RNA nucleosides, recently discovered and analyzed in their ultrahigh-resolution X-ray crystal structures (Sychrovsky´; et al. Nucleic Acid Res. 2009, 37, 7321.), were found to have significant
Sychrovský, V., Sub Cellular Protein Chemistry, Vokáčová, Z., Trantirek, L., Cellular Protein Chemistry   +4 more
core  

GABA(A) receptor phospho-dependent modulation is regulated by phospholipase C-related inactive protein type 1, a novel protein phosphatase 1 anchoring protein [PDF]

, 2004
GABA(A) receptors are critical in controlling neuronal activity. Here, we examined the role for phospholipase C-related inactive protein type 1 (PRIP-1), which binds and inactivates protein phosphatase 1alpha (PP1alpha) in facilitating GABA(A) receptor ...
Kanematsu, T, Terunuma, M, Jovanovic, JN, Jang, IS, Kittler, JT, Akaike, N, Nakayama, KI, Ryu, SH, Moss, SJ, Ha, SH, Hirata, M   +10 more
core  

Signaling into the nucleus through the importin 7 pathway. [PDF]

J Biol Chem
Palchevska O, Ko YH, Cingolani G.
europepmc   +1 more source

Prognostic Value of Exportin-7 and Its Association with <i>KRAS</i> Status and Autophagy Markers in Small Intestinal Adenocarcinoma. [PDF]

Life (Basel)
Kim JW, Ylaya K, Chung EJ, Jun SY, Hong SM, Chung JY.   +5 more
europepmc   +1 more source

Phytophthora capsici carries and differentially expresses genes for the RNA interference pathway. [PDF]

PLoS One
Sevillano-Serrano J, Rojas-Rojas FU, Méndez-Bravo A, Calderón-Cortés N, Shimada-Beltrán H, Vega-Arreguín J.   +5 more
europepmc   +1 more source

Post-Transcriptional Regulators of Inflammation: The Role of microRNAs in Acne Inversa Pathogenesis. [PDF]

J Biochem Mol Toxicol
Bahashwan E.
europepmc   +1 more source

Nuclear-Cytoplasmic Axis in Cancer: From Protein Mislocalization to Anticancer Drug Resistance. [PDF]

Oncol Res
Zhu X, He M, Wang L, Su R, Zhong L, Guo T, Wang H, Zou D.   +7 more
europepmc   +1 more source