Results 101 to 110 of about 21,055 (183)

Selinexor Sensitizes TRAIL-R2-Positive TNBC Cells to the Activity of TRAIL-R2xCD3 Bispecific Antibody

Cells, 2020
Triple-negative breast cancer (TNBC) is an aggressive disease with poor prognosis and limited therapeutic options. Recent advances in the immunotherapy field have enabled the development of new treatment strategies, among which the use of bispecific ...
Silvia Martini, Mariangela Figini, Aurora Croce, Barbara Frigerio, Marzia Pennati, Alessandro Massimo Gianni, Cinzia De Marco, Maria Grazia Daidone, Christian Argueta, Yosef Landesman, Nadia Zaffaroni, Alessandro Satta   +11 more
doaj   +1 more source

Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline [PDF]

, 2010
<b>Objective</b>: MicroRNAs (miRNAs) are small noncoding RNAs that have the capacity to control protein production through binding "seed" sequences within a target mRNA. Each miRNA is capable of potentially controlling hundreds of genes.
Baker, Andrew H., Caruso, Paola, Dempsie, Yvonne, Denby, Laura, Greig, Jenny A., Khanin, Raya, Long, Lu, MacDonald, Robert A., MacLean, Margaret R., Masson, Rachel, McClure, John, Morrell, Nicholas W., Robertson, Keith E., Soon, Elaine, Southgate, Mark   +14 more
core   +1 more source

2026 Update on the Management of Diffuse Large B‐Cell Lymphoma

American Journal of Hematology, Volume 101, Issue 4, Page 832-863, April 2026.
ABSTRACT Diffuse large B‐cell lymphoma (DLBCL) is the most common type of NHL in the Western Hemisphere. It comprises a heterogenous group of lymphomas, with different biology and clinical prognoses. R‐CHP remains the backbone of therapy, and frontline therapeutic options in fit patients are pola‐R‐CHP and R‐CHOP, whereas elderly or frail/unfit ...
Elise A. Chong, Emily B. Tomasulo, Stefan K. Barta   +2 more
wiley   +1 more source

Chromosome‐scale genome assembly of the South American fruit fly, Anastrepha fraterculus sp.1

Insect Science, Volume 33, Issue 2, Page 640-664, April 2026.
Anastrepha fraterculus sp. 1 is a major fruit fly pest in Argentina, currently controlled through chemical treatments and traps. This study aims to enhance the genomic understanding of this species to support the development of sterile insect technique as well as the use of innovative technologies.
Máximo Rivarola, Claudia A. Conte, Pierre Berube, Shu‐Huang Chen, M. Cecilia Giardini, Alejandra C. Scannapieco, Fabián H. Milla, María C. Soria, Romina M. Russo, Juan P. Wulff, Haig H. Djambazian, Rolando R. Pomar, Alfred M. Handler, Kostas Bourtzis, Ioannis Ragoussis, Silvia B. Lanzavecchia   +15 more
wiley   +1 more source

Reversible Oxidation of a Conserved Methionine in the Nuclear Export Sequence Determines Subcellular Distribution and Activity of the Fungal Nitrate Regulator NirA [PDF]

, 2015
The assimilation of nitrate, a most important soil nitrogen source, is tightly regulated in microorganisms and plants. In Aspergillus nidulans, during the transcriptional activation process of nitrate assimilatory genes, the interaction between the ...
Gallmetzer, Andreas, Kungl, Andreas, Muro Pastor, María Isabel, Schinko, Thorsten, Silvestrini, Lucia   +4 more
core   +1 more source

Characterizing the normal proteome of human ciliary body [PDF]

, 2013
BACKGROUND: The ciliary body is the circumferential muscular tissue located just behind the iris in the anterior chamber of the eye. It plays a pivotal role in the production of aqueous humor, maintenance of the lens zonules and accommodation by changing
Akhilesh Pandey, Anil K Madugundu, Dhanashree S Kelkar, Gourav Dey, HC Harsha, Krishna R Murthy, Mitali Bhattacharjee, Renu Goel, Shukti Chakravarti, Sneha M Pinto, Srinivas M Srikanth, Sujatha S Mohan, TS Prasad, Venkatarangaiah Krishna   +13 more
core   +1 more source

Nucleocytoplasmic transport: taking an inventory [PDF]

, 2018
In eukaryotic cells, the enclosure of the genetic information in the nucleus allows the spatial and temporal separation of DNA replication and transcription from cytoplasmic protein synthesis.
Fried, H., Kutay, U.
core  

The role of Micro-RNAs in Hepatocellular Carcinoma: From Molecular Biology to Treatment [PDF]

, 2014
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third leading cause of cancer deaths. microRNAs (miRNAs) are evolutionary conserved small non-coding RNA that negatively regulate gene expression and protein translation ...
Bianconi Maristella, Cascinu Stefano, D'Anzeo Marco, Del Prete Michela, Faloppi Luca, Giampieri Riccardo, SCARTOZZI, MARIO, Silvestris Nicola   +7 more
core   +1 more source

Selinexor in acute myeloid leukemia: therapeutic applications and current challenges

Frontiers in Pharmacology
This article aims to review the current application status and research advancements of selinexor in the treatment of acute myeloid leukemia (AML). Selinexor, as the first oral selective inhibitor of nuclear export protein Exportin-1 (XPO1), inhibits the
Ziyu Qie, Li Ma, Jie Tan, Xiaochun Peng, Xiaochun Peng   +4 more
doaj   +1 more source

XPO1 serves as a prognostic marker involving AKT/MAPK/TGFBR1 pathway in OSCC

Cancer Medicine
Background Exportin 1 (XPO1) is a nuclear export protein that facilitates the transportation of various substances. XPO1 promotes tumor development as a poor prognostic factor in a variety of tumors and is a therapeutic target for screening inhibitors ...
Ying Han, Ying Peng, Haofeng Xiong, Liujun Zeng, Tianyi Zhang, Kun Xia, Xin Hu, Tong Su   +7 more
doaj   +1 more source