Results 91 to 100 of about 32,019,221 (177)

Using the cre-lox recombination system to assess functional impairment caused by amino acid substitutions in yeast proteins

Biological Procedures Online, 2004
A method was developed to assess the functional significance of a sequence motif in yeast Upf3p, a protein required for nonsense-mediated mRNA decay (NMD).
Shirley Renee L., Richards M. Rachel, Culbertson Michael R.   +2 more
doaj   +1 more source

MicroRNA‐Mediated Placental Maladaptation in Preeclampsia Pathogenesis

FASEB BioAdvances, Volume 8, Issue 9, September 2026.
Graphical representation of miRNA‐mediated placental maladaptation in preeclampsia. Under normal pregnancy conditions, balanced expression of beneficial miRNAs (miR‐126‐3p, miR‐18a/b‐5p, miR‐144‐3p, miR‐378a‐5p, and miR‐146a‐5p) promotes trophoblast proliferation, migration and invasion, spiral artery remodeling, angiogenesis, mitochondrial function ...
Sarbani Saha, Rupasri Ain
wiley   +1 more source

Nuclear MEK1 sequesters PPARγ and bisects MEK1/ERK signaling: a non-canonical pathway of retinoic acid inhibition of adipocyte differentiation.

PLoS ONE, 2014
Uncontrolled adipogenesis and adipocyte proliferation have been connected to human comorbidities. Retinoic acid (RA) is known to inhibit adipocyte differentiation, however the underlying mechanisms have not been adequately understood.
Sandeep Dave, Ravikanth Nanduri, Hedwin Kitdorlang Dkhar, Ella Bhagyaraj, Alka Rao, Pawan Gupta   +5 more
doaj   +1 more source

Understanding and addressing resistance to IMiDs immunomodulatory compounds in multiple myeloma

The FEBS Journal, Volume 293, Issue 17, Page 5121-5139, September 2026.
IMiDs are pivotal in the treatment of multiple myeloma. Mechanisms of resistance comprise cell intrinsic and extrinsic pathways, involving tumour microenvironment, immune cell dysfunction, CRBN‐dependent and independent genetic drivers and epigenetic changes.
Maria‐Cynthia Fuentes‐Lacouture, Devi Nandana, Karthik Ramasamy, Anjan Thakurta   +3 more
wiley   +1 more source

Automatically extracting functionally equivalent proteins from SwissProt [PDF]

, 2008
Background: There is a frequent need to obtain sets of functionally equivalent homologous proteins (FEPs) from different species. While it is usually the case that orthology implies functional equivalence, this is not always true; therefore datasets of ...
McMillan, LEM, Lisa EM McMillan, Martin Andrew CR, Martin, Andrew C.R., Andrew CR Martin, McMillan, Lisa E.M., Martin, ACR, McMillan Lisa EM   +7 more
core   +1 more source

Hypoxia‐inducible factor‐1a (HIF1a) as a context‐dependent integrator of metabolic stress in skeletal muscle

The Journal of Physiology, Volume 604, Issue 18, Page 7539-7558, 15 September 2026.
Abstract figure legend Hypoxia‐inducible factor‐1a (HIF1a) integrates physiological and pathological inputs in skeletal muscle, including exercise, circadian timing, cytotoxins and disease. These inputs alter mitochondrial oxidative function, redox state, reactive oxygen species, and local oxygen availability, leading to intermittent or sustained HIF1a
Nicole Welch, Pugazhendhi Kannan, Seshu Vardhan Pothabathula, Annette Bellar, Abhishek A. Chakraborty, Saurabh Mishra, Srinivasan Dasarathy   +6 more
wiley   +1 more source

Analysis of Disulfide Bond Formation [PDF]

, 2017
In this unit, protocols are provided for detection of disulfide bond formation in cultures of intact cells and in an in vitro translation system containing isolated microsomes or semi-permeabilized cells.
Sub Cellular Protein Chemistry, Ineke Braakman, Hebert, Daniel N., Lydia Lamriben, Guus van Zadelhoff, van Zadelhoff, Guus, Braakman, Ineke, Daniel N. Hebert, Lamriben, Lydia, Cellular Protein Chemistry   +9 more
core   +2 more sources

Immunosuppressive Yersinia Effector YopM Binds DEAD Box Helicase DDX3 to Control Ribosomal S6 Kinase in the Nucleus of Host Cells.

PLoS Pathogens, 2016
Yersinia outer protein M (YopM) is a crucial immunosuppressive effector of the plaque agent Yersinia pestis and other pathogenic Yersinia species. YopM enters the nucleus of host cells but neither the mechanisms governing its nucleocytoplasmic shuttling ...
Laura Berneking, Marie Schnapp, Andreas Rumm, Claudia Trasak, Klaus Ruckdeschel, Malik Alawi, Adam Grundhoff, Alexey G Kikhney, Friedrich Koch-Nolte, Friedrich Buck, Markus Perbandt, Christian Betzel, Dmitri I Svergun, Moritz Hentschke, Martin Aepfelbacher   +14 more
doaj   +1 more source

Peroxisomal membrane proteins insert into the endoplasmic reticulum [PDF]

, 2010
We show that a comprehensive set of 16 peroxisomal membrane proteins (PMPs) encompassing all types of membrane topologies first target to the endoplasmic reticulum (ER) in Saccharomyces cerevisiae.
Sub Cellular Protein Chemistry, van der Zand, A., Tabak, H.F., Braakman, L.J., Cellular Protein Chemistry   +4 more
core   +1 more source

Enhanced Antitumor Activity by the Combination of Dasatinib and Selinexor in Chronic Myeloid Leukemia

Pharmaceuticals
Background: Chronic myeloid leukemia is a hematological malignancy characterized by the abnormal proliferation of leukemic cells. Despite significant progress with tyrosine kinase inhibitors, such as Dasatinib, resistance remains a challenge.
Mariarita Spampinato, Tatiana Zuppelli, Ilaria Dulcamare, Lucia Longhitano, Domenico Sambataro, Annalisa Santisi, Amer M. Alanazi, Ignazio A. Barbagallo, Nunzio Vicario, Rosalba Parenti, Alessandra Romano, Giuseppe Musumeci, Giovanni Li Volti, Giuseppe A. Palumbo, Francesco Di Raimondo, Anna Nicolosi, Sebastiano Giallongo, Vittorio Del Fabro   +17 more
doaj   +1 more source