Results 91 to 100 of about 21,055 (183)

Targeting the nuclear export receptor exportin‐1 in acute myeloid leukaemia: From biology to clinical translation

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
• XPO1 hyperactivation promotes leukaemogenesis by altering nucleocytoplasmic transport and transcriptional control in acute myeloid leukaemia (AML). • Selinexor and eltanexor show preferential activity in NPM1‐mutated, DEK::NUP214‐positive and SF3B1‐mutated myeloid neoplasms.
Yifan Liu, Xiaoya Yun, Weidong Ding, Suxiao Li, Hui Liu   +4 more
wiley   +1 more source

Effect of Exportin 1/XPO1 Nuclear Export Pathway Inhibition on Coronavirus Replication

Viruses
The nucleocytoplasmic transport of proteins using XPO1 (exportin 1) plays a vital role in cell proliferation and survival. Many viruses also exploit this pathway to promote infection and replication.
Masmudur M. Rahman, Bereket Estifanos, Honor L. Glenn, Ami D. Gutierrez-Jensen, Karen Kibler, Yize Li, Bertram Jacobs, Grant McFadden, Brenda G. Hogue   +8 more
doaj   +1 more source

Nuclear MEK1 sequesters PPARγ and bisects MEK1/ERK signaling: a non-canonical pathway of retinoic acid inhibition of adipocyte differentiation.

PLoS ONE, 2014
Uncontrolled adipogenesis and adipocyte proliferation have been connected to human comorbidities. Retinoic acid (RA) is known to inhibit adipocyte differentiation, however the underlying mechanisms have not been adequately understood.
Sandeep Dave, Ravikanth Nanduri, Hedwin Kitdorlang Dkhar, Ella Bhagyaraj, Alka Rao, Pawan Gupta   +5 more
doaj   +1 more source

Exercise and Skeletal Muscle‐Derived Extracellular Vesicles: Their Cargo, Release, and Role in Metabolic Regulation

Journal of Extracellular Biology, Volume 5, Issue 5, May 2026.
ABSTRACT The health benefits of exercise are well established in the prevention and management of metabolic disorders such as obesity and diabetes. Emerging evidence indicates that extracellular vesicles (EVs) may contribute to the beneficial effects of exercise.
Jeremy Boulestreau, Scott K. Ferguson, Luke Nelson, Noemi Polgar   +3 more
wiley   +1 more source

Components and regulation of nuclear transport processes [PDF]

, 2015
The spatial separation of DNA replication and gene transcription in the nucleus and protein translation in the cytoplasm is a uniform principle of eukaryotic cells. This compartmentalization imposes a requirement for a transport network of macromolecules
Alefantis, Argentaro, Arnaoutov, Arts, Arts, Askjaer, Bardina, Bayliss, Beals, Beck, Bednenko, Beg, Belov, Bernad, Bischoff, Bogerd, Bohnsack, Bohnsack, Bono, Bourne, Brickner, Bui, Bunn, Calado, Callan, Caly, Capelson, Carmody, Castello, Cautain, Chen, Chook, Ciufo, Conti, Conti, Cook, Cour, Craig, Cronshaw, Debler, Devos, Dingwall, Dong, Dong, Dorfman, Englmeier, Erickson, Erkmann, Ertel, Feng, Ferrigno, Field, Fineberg, Fischer, Fontoura, Fornerod, Fornerod, Frey, Frey, Fried, Frieman, Fu, Fu, Fukuda, Fukuda, Gadal, Ghildyal, Goldfarb, Gontan, Gorlich, Gorlich, Grespin, Grossman, Gustin, Gustin, Guttler, Hall, Harel, Hellmuth, Henderson, Hill, Hill, Ho, Hoelz, Holaska, Hopper, Huang, Huber, Hubner, Hung, Hussain, Hutten, Hutten, Isgro, Izaurralde, Kalab, Kalderon, Kalderon, Katahira, Kehlenbach, Kehlenbach, Kobbe, Kohler, Komeili, Kopecky-Bromberg, Kosugi, Kosugi, Kosugi, Krull, Kunzler, Kunzler, Kurisaki, Kutay, Kutay, Lam, Lange, Lange, Lange, Lee, Lee, Lidsky, Lim, Lim, Lim, Lim, Lindsay, Long, Luna, Lund, Macara, Maimon, Makkerh, Malik, Malim, Malim, Malim, Malim, Marfori, Mateo, Maurer, Melchior, Melcák, Mingot, Mingot, Mitchell, Monecke, Moore, Moore, Mor, Mosammaparast, Murdoch, Nemergut, Neumann, Ohno, Ossareh-Nazari, Paraskeva, Park, Peters, Porter, Prieto, Ren, Rexach, Ribbeck, Richards, Riviere, Rodriguez, Rodriguez-Navarro, Rouquette, Rout, Rout, Sarma, Schwartz, Shabman, Shin, Shuai, Siddiqui, Solsbacher, Sorokin, Speese, Stade, Stommel, Strambio-De-Castillia, Suel, Therizols, Thomas, Traenckner, Tran, Truant, Turner, Turner, Vosse, Wagstaff, Walther, Watters, Weighardt, Wen, Wen, Wente, Wild, Xu, Xu, Yang, Yi, Zanella   +203 more
core   +1 more source

MicroRNA‐375‐3p Targets Fatty Acid Synthase and Relish to Regulate Energy Allocation During Pupal Metamorphosis and Starvation

Advanced Science, Volume 13, Issue 20, 9 April 2026.
During pupal metamorphosis and starvation, elevated 20‐hydroxyecdysone (20E) and suppressed insulin trigger Forkhead box O (FOXO) nuclear translocation, enhancing miR‐375‐3p expression. This downregulates fatty acid synthase (FASN) and Relish, promoting lipid breakdown for energy while prioritizing antioxidant responses over immune functions to support
Peng Chen, Meiqi Cheng, Jianhui Wang, Jing Tang, Xiaoqiao Huang, Yusi Li, Huiling Zhou, Ling Zhang, Yi Dong, Chengjun Li, Bin Li   +10 more
wiley   +1 more source

Single Nucleotide Polymorphisms of MicroRNA Processing Machinery Genes and Outcome of Hepatocellular Carcinoma [PDF]

, 2014
MicroRNA (miRNA)-related single nucleotide polymorphisms (miR-SNPs) can affect cancer development, treatment efficacy and patients prognosis. We examined 6 miR-SNPs in miRNA processing machinery genes including exportin 5 (XPO5) (rs11077), Ran-GTPase ...
An, Jie, Bao, Lidao, Lin, Jianhong, Liu, Shuang, Liu, Yanli, Zhang, Wen, Zhao, Jian-Jun   +6 more
core   +2 more sources

Ascites circRNA ASCOR Drives Platinum Resistance of High‐Grade Serous Ovarian Cancer by Facilitating RPA1 Nuclear Translocation

Advanced Science, Volume 13, Issue 23, 23 April 2026.
High‐grade serous ovarian carcinoma (HGSOC) is plagued by platinum resistance, with malignant ascites closely linked to poor outcomes. Here, we identify ASCOR, a circRNA enriched in ascites small extracellular vesicles (sEVs) from platinum‐resistant HGSOC patients, as a predictor of poor survival. ASCOR enhances platinum resistance in vitro and in vivo
Hanyuan Liu, Chenchen Zhu, Xuelin Yao, Yi Liu, Jing Zhu, Yuebo Li, Hanjie Xu, Cheng Peng, Ge Shan, Liang Chen, Ying Zhou   +10 more
wiley   +1 more source

Enhanced Antitumor Activity by the Combination of Dasatinib and Selinexor in Chronic Myeloid Leukemia

Pharmaceuticals
Background: Chronic myeloid leukemia is a hematological malignancy characterized by the abnormal proliferation of leukemic cells. Despite significant progress with tyrosine kinase inhibitors, such as Dasatinib, resistance remains a challenge.
Mariarita Spampinato, Tatiana Zuppelli, Ilaria Dulcamare, Lucia Longhitano, Domenico Sambataro, Annalisa Santisi, Amer M. Alanazi, Ignazio A. Barbagallo, Nunzio Vicario, Rosalba Parenti, Alessandra Romano, Giuseppe Musumeci, Giovanni Li Volti, Giuseppe A. Palumbo, Francesco Di Raimondo, Anna Nicolosi, Sebastiano Giallongo, Vittorio Del Fabro   +17 more
doaj   +1 more source

Immunosuppressive Yersinia Effector YopM Binds DEAD Box Helicase DDX3 to Control Ribosomal S6 Kinase in the Nucleus of Host Cells.

PLoS Pathogens, 2016
Yersinia outer protein M (YopM) is a crucial immunosuppressive effector of the plaque agent Yersinia pestis and other pathogenic Yersinia species. YopM enters the nucleus of host cells but neither the mechanisms governing its nucleocytoplasmic shuttling ...
Laura Berneking, Marie Schnapp, Andreas Rumm, Claudia Trasak, Klaus Ruckdeschel, Malik Alawi, Adam Grundhoff, Alexey G Kikhney, Friedrich Koch-Nolte, Friedrich Buck, Markus Perbandt, Christian Betzel, Dmitri I Svergun, Moritz Hentschke, Martin Aepfelbacher   +14 more
doaj   +1 more source