Results 81 to 90 of about 21,055 (183)

Structures of Ras superfamily effector complexes: What have we learnt in two decades? [PDF]

, 2015
The Ras superfamily small G proteins are master regulators of a diverse range of cellular processes and act via downstream effector molecules. The first structure of a small G protein-effector complex, that of Rap1A with c-Raf1, was published 20 years ...
Mott, Helen R, Owen, Darerca
core   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, Volume 16, Issue 5, Page 921-931, May 2026.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Peroxiredoxin-mediated disulfide bond formation is required for nucleocytoplasmic translocation and secretion of HMGB1 in response to inflammatory stimuli

Redox Biology, 2019
The nuclear protein HMGB1 (high mobility group box 1) is secreted by monocytes-macrophages in response to inflammatory stimuli and serves as a danger-associated molecular pattern.
Man Sup Kwak, Hee Sue Kim, Khulan Lkhamsuren, Young Hun Kim, Myeong Gil Han, Jae Min Shin, In Ho Park, Woo Joong Rhee, Se Kyoung Lee, Sue Goo Rhee, Jeon-Soo Shin   +10 more
doaj   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, Volume 16, Issue 5, Page 837-856, May 2026.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

4-Hydroxy-2-nonenal causes nuclear accumulation of p62 by inhibiting Xpo1 and promoting the proteolytic pathway in the nucleus.

PLoS ONE
p62, an adapter protein involved in selective autophagy, is mainly found in the cytoplasm under normal conditions. Because p62 has nuclear localization signal (NLS) and a nuclear export signal, it has been suggested that p62 shuttles between the nucleus ...
Emi Kayama, Ning Baoshuo, Rinna Tatsuno, Kanako Nishi, Elsayed S I Mohammed, Yumi Abiko, Toru Yanagawa, Satoru Takahashi, Eiji Warabi   +8 more
doaj   +1 more source

Selinexor and Venetoclax Combination in Patients With Relapsed or Refractory Acute Myeloid Leukemia

American Journal of Hematology, Volume 101, Issue 5, Page 1019-1024, May 2026.
ABSTRACT Preclinical studies showed a synergistic antileukemia activity with combination of selective XPO1 inhibitor selinexor (SEL) and venetoclax (VEN), with potential to overcome VEN resistance by reducing the anti‐apoptotic protein MCL1. In an investigator‐sponsored, open‐label, phase Ib study (NCT03955783), adult patients with relapsed or ...
Somedeb Ball, Farrukh T. Awan, Ben K. Tomlinson, Tess Stopczynski, Melissa A. Fischer, Zhiguo Zhao, Kateryna Fedorov, Ashwin Kishtagari, Sanjay R. Mohan, Gregory D. Ayers, Michael T. Byrne, Michael R. Savona   +11 more
wiley   +1 more source

Deficiency of Pkc1 activity affects glycerol metabolism in Saccharomyces cerevisiae [PDF]

, 2005
In pressProtein kinase C is apparently involved in the control of many cellular systems: the cell wall integrity pathway, the synthesis of ribosomes, the appropriated reallocation of transcription factors under specific stress conditions and also the ...
Alepuz P.M., Andrews P.D., Bill R.M., Boukaba A., Brandao R.L., Buehrer B.M., Castro I.M., Celenza J.L., Chang M., Davie J.K., Delley P.A., DeVit M.J., Estruch F., Estruch F., Goldstein A., Grauslund M., Gray J.V., Hardie D.G., Harrison J.C., Heinisch J.J., Herrero P., Hohmann S., Holst B., Hong S., Ito H., Kingston R.E., Lages F., Lages F., Larsson C., Lowry O.H., Luyten K., Mazzoni C., Nanduri J., Nath N., Neves L., Oliveira R., Ozcan S., Park H., Pavlik P., Philips J., Ronnow B., Sal G., Salgado A.P.C., Sanger F., Schmitz H.-P., Schuller H.-J., Sekiya-Kawasaki M., Smith R., Souza M.A.A., Sprague G.F., Sreenivas A., Sutherland F.C., Tamas M.J., Wang A., Watson A.D., Wojda I., Young E.T., Zhao C.   +57 more
core   +1 more source

MicroRNA‐Mediated Regulation of Brain Aging Hallmarks: Implications for Neurodegeneration and Neural Recovery

Brain and Behavior, Volume 16, Issue 5, May 2026.
Hallmarks of brain aging regulated by microRNAs (miRNAs). This graphical abstract illustrates the central role of miRNAs in coordinating key biological processes associated with brain aging. miRNAs regulate multiple interconnected hallmarks, including genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis and impaired ...
Mustafa T. Ardah, Pareshkumar N. Patel, Omayma Salim Waleed, Jamuna K. V., Vandana Tripathi, L. Lakshmi, Rajashree Panigrahi, Manoj Kumar Mishra   +7 more
wiley   +1 more source

Using the cre-lox recombination system to assess functional impairment caused by amino acid substitutions in yeast proteins

Biological Procedures Online, 2004
A method was developed to assess the functional significance of a sequence motif in yeast Upf3p, a protein required for nonsense-mediated mRNA decay (NMD).
Shirley Renee L., Richards M. Rachel, Culbertson Michael R.   +2 more
doaj   +1 more source

RCC1-dependent activation of Ran accelerates cell cycle and DNA repair, inhibiting DNA damage–induced cell senescence [PDF]

, 2016
© The Author(s), 2016. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Molecular Biology of the Cell 27 (2016): 1346-1357, doi:10.1091/mbc.E16-01-0025.The coordination of ...
Cekan, Pavol, Chen, Jin-Qiu, Hasegawa, Keisuke, Herrmann, Michelle A., Kalab, Petr, Kumar, Sheetal, Odde, David, Pan, Yu, Tubman, Emily   +8 more
core   +1 more source