Results 111 to 120 of about 21,055 (183)

SUMO regulates p21Cip1 intracellular distribution and with p21Cip1 facilitates multiprotein complex formation in the nucleolus upon DNA damage.

PLoS ONE, 2017
We previously showed that p21Cip1 transits through the nucleolus on its way from the nucleus to the cytoplasm and that DNA damage inhibits this transit and induces the formation of p21Cip1-containing intranucleolar bodies (INoBs).
Sonia Brun, Neus Abella, Maria T Berciano, Olga Tapia, Montserrat Jaumot, Raimundo Freire, Miguel Lafarga, Neus Agell   +7 more
doaj   +1 more source

p35 regulates the CRM1-dependent nucleocytoplasmic shuttling of nuclear hormone receptor coregulator-interacting factor 1 (NIF-1).

PLoS ONE, 2014
Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase, which plays critical roles in a wide spectrum of neuronal functions including neuronal survival, neurite outgrowth, and synapse development and plasticity.
Xiao-Su Zhao, Wing-Yu Fu, Winnie W Y Chien, Zhen Li, Amy K Y Fu, Nancy Y Ip   +5 more
doaj   +1 more source

Effect of Nuclear Export Inhibitor Leptomycin B on the Intracellular Localization of HBV Core Protein into Hepatocytes Cell Line Huh-7 and HepG2 Cells

Indonesian Journal of Biotechnology, 2015
Leptomycin B (LMB) was originally discovered as a potent anti-fungal antibiotic from Streptomyces species. The cellular target of LMB has been identified as the nuclear export receptor CRM-1 or exportin-1, which is involved in nuclear trafficking of ...
Aris Haryanto, Nastiti Wijayanti, Michael Kann   +2 more
doaj  

The interplay between viral-derived miRNAs and host immunity during infection [PDF]

, 2019
MicroRNAs are short non-coding RNAs that play a crucial role in the regulation of gene expression during cellular processes. The host-encoded miRNAs are known to modulate the antiviral defense during viral infection.
Ingle, Harshad, Kumar, Ashish, Kumar, Himanshu, Mishra, Richa   +3 more
core   +1 more source

A Novel Approach of Virotherapy Based Hsf-1 Shrna in Cancer Eradication [PDF]

, 2013
Cancer is the second leading cause of death worldwide with continues rise mortality rate. Current cancer treatment modalities are still ineffective and associated with many side effects leading to robust research to find new specific target therapy. Heat
Supadmanaba, I. G. (I), Wibawa-Manuaba, I. B. (I)   +1 more
core  

Validation of Exportin-1 (XPO1) and Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2) as Molecular Drug Targets in Amyotrophic Lateral Sclerosis [PDF]

Amyotrophic lateral sclerosis (ALS) is a progressing neurodegenerative disorder. This study validates ALS treatment targets derived from MAXOMOD consortium research. Multiomic analysis of human postmortem prefrontal cortex and ALS mouse models identified XPO1 and MAP2K2 for in vitro validation.
openaire  

Importins promote high-frequency NF-κB oscillations increasing information channel capacity [PDF]

, 2016
Joanna Markiewicz, Karolina Tudelska, Maciej Czerkies, Marek Kochańczyk, Paweł Nałęcz-Jawecki, Tomasz Lipniacki, Wiktor Prus, Zbigniew Korwek   +7 more
core   +1 more source

Phytophthora capsici carries and differentially expresses genes for the RNA interference pathway. [PDF]

PLoS One
Sevillano-Serrano J, Rojas-Rojas FU, Méndez-Bravo A, Calderón-Cortés N, Shimada-Beltrán H, Vega-Arreguín J.   +5 more
europepmc   +1 more source

Stay with me: rPL4 kidnaps the viral replicase to limit TVBMV infection. [PDF]

Plant Physiol
Uranga M.
europepmc   +1 more source

RNA export through the nuclear pore complex: pathways, mechanisms, and imaging strategies. [PDF]

RNA Biol
Fu D, Yu W, Zhang F, Rush C, Tingey M, Yang W.   +5 more
europepmc   +1 more source