Results 181 to 190 of about 134,736 (276)

Trans-genetic effects of circular RNA expression quantitative trait loci and potential causal mechanisms in autism. [PDF]

Mol Psychiatry, 2022
Mai TL, Chen CY, Chen YC, Chiang TW, Chuang TJ.   +4 more
europepmc   +1 more source

Alzheimer's Biomarkers and Visuospatial Cognition in Parkinson's Disease: Modification by α‐Synuclein and Mediation of Age Effects

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Visuospatial deficits in Parkinson's disease (PD) often precede dementia and complicate daily functioning. Alzheimer's disease (AD) pathology and α‐synuclein aggregation frequently co‐occur in PD, but their combined impact on cognition is unclear.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Meher Lad, Mark R. Baker, Nicola Pavese   +8 more
wiley   +1 more source

Serum microRNA expression quantitative trait loci in children with asthma colocalize with asthma-related GWAS results. [PDF]

NPJ Genom Med
Hecker J, Tiwari A, Sharma R, Mendez K, Li J, Begum S, Chen Q, Smith A, Celedón JC, Weiss ST, Kelly RS, Lasky-Su JA, Tantisira KG, McGeachie M.   +13 more
europepmc   +1 more source

Identifying cancer tissue-of-origin by a novel machine learning method based on expression quantitative trait loci. [PDF]

Front Oncol, 2022
Miao Y, Zhang X, Chen S, Zhou W, Xu D, Shi X, Li J, Tu J, Yuan X, Lv K, Tian G.   +10 more
europepmc   +1 more source

MendelR: A One‐Stop R Toolkit for Mendelian Randomization Analysis

Med Research, EarlyView.
ABSTRACT MendelR is a fully automated R package specifically developed for Mendelian randomization (MR) studies, designed to address the technical challenges of causal inference in biomedical research. As a powerful causal inference method, Mendelian randomization can effectively reduce confounding bias in observational studies.
Xiaohong Ke, Kailai Li, Anqi Lin, Yasi Zhang, Peng Luo   +4 more
wiley   +1 more source

Comprehensive Evidence for Mortality and Underlying Morbidity Related to Visceral Fat Distribution

Med Research, EarlyView.
ABSTRACT Linking obesity to mortality is an intriguing and controversial topic. This study tried to comprehensively assess 8 adiposity surrogates and mortality association among middle‐to‐old‐aged adults to identify a superior one, and explore explanatory disorders. Data sources included the National Health and Nutrition Examination Survey (NHANES), UK
Haolong Zhou, Danyang Ling, Qin Huang, Jiaojun Liang, Guanhua Su, Zhangbo Cui, Ziwei Chen, Xiaowen Ma, Zhou Jiang, Shuo Zheng, Haodong Tian, Qi Wang   +11 more
wiley   +1 more source

The Expression Quantitative Trait Loci in Immune Response Genes Impact the Characteristics and Survival of Colorectal Cancer. [PDF]

Diagnostics (Basel), 2022
Chan RH, Chen PC, Yeh YM, Lin BW, Yang KD, Shen MR, Lin PC.   +6 more
europepmc   +1 more source

Biomarkers of Leucine‐Rich Repeat Kinase 2 (LRRK2) and Lysosomal Dysfunction in Progressive Supranuclear Palsy

Movement Disorders, EarlyView.
Abstract Background Common and rare genetic variants in leucine‐rich repeat kinase 2 (LRRK2) have been linked with sporadic and familial Parkinson's disease (PD). Recently, we discovered that common genetic variation near the LRRK2 locus determined survival in progressive supranuclear palsy (PSP).
Louise‐Kristine Nielsen, Joshua L.I. Frost, David P. Vaughan, Raquel Real, Riona Fumi, Marte Theilmann Jensen, Megan Hodgson, Eleanor J. Stafford, Lesley Wu, Olaf Ansorge, Annelies Quaegebeur, Kieren S.J. Allinson, Thomas T. Warner, Zane Jaunmuktane, Anjum Misbahuddin, P. Nigel Leigh, Boyd C.P. Ghosh, Kailash P. Bhatia, Alistair Church, Christopher Kobylecki, Michele T.M. Hu, James B. Rowe, Alan A. Shomo, Danielle L. Graham, Omar S. Mabrouk, Huw R. Morris, Esther M. Sammler, Edwin Jabbari   +27 more
wiley   +1 more source

Causal network inference of cis- and trans-gene regulation of expression quantitative trait loci across human tissues. [PDF]

Genetics
Kvamme J, Badsha MB, Martin EA, Wu J, Wang X, Fu AQ.   +5 more
europepmc   +1 more source

Expression quantitative trait loci for ETV4 and MEOX1 are associated with adult asthma in Japanese populations. [PDF]

Sci Rep, 2021
Yatagai Y, Oshima H, Sakamoto T, Shigemasa R, Kitazawa H, Hyodo K, Masuko H, Iijima H, Naito T, Saito T, Hirota T, Tamari M, Hizawa N.   +12 more
europepmc   +1 more source