Results 201 to 210 of about 134,736 (276)

Single‐nucleotide polymorphisms in coronary artery disease: Biological complexity, risk architecture, and implications for precision prevention

Precision Medical Sciences, EarlyView.
This graphical summary highlights the clinical application of single‐nucleotide polymorphisms‐based risk stratification in coronary artery disease. By integrating polygenic risk with clinical assessment, imaging, and preventive strategies, genetic information enables earlier risk identification, optimized screening, and personalized lifestyle and ...
Li Dai, Mosi Chen, Jun Hu, Lei Huang, Ye Yang, Chang Chen, Ying Zhuang, Yan Pan, Bingjun Qian   +8 more
wiley   +1 more source

Integrative Transcriptome-Wide Association Study With Expression Quantitative Trait Loci Colocalization Identifies a Causal VAMP8 Variant for Nasopharyngeal Carcinoma Susceptibility. [PDF]

Adv Sci (Weinh)
Liang Y, Xiong XY, Lin GW, Bai X, Li F, Ko JM, Zhou YH, Xu AY, Liu SQ, He S, Wei PP, Chen QY, Tang LQ, Wang VY, Mai HQ, Luo CL, Zeng Y, Lung ML, Ji M, Bei JX.   +19 more
europepmc   +1 more source

Monitoring fungicide resistance frequencies – a case study of barley net blotch

Pest Management Science, EarlyView.
Droplet digital PCR revealed the frequency of alleles associated with decreased sensitivity to demethylation inhibitor (DMI) and succinate dehydrogenase inhibitor (SDHI) fungicides in Pyrenophora teres from barley net blotch in Western Australia. The findings highlight field‐level allele dynamics and emerging risks to fungicide efficacy.
Noel L. Knight, Kul C. Adhikari, Wesley J. Mair, Kejal Dodhia, Katherine G. Zulak, Francisco J. Lopez‐Ruiz   +5 more
wiley   +1 more source

Thirty years of glyphosate‐resistant crops and weeds: Current situation and future prospects

Pest Management Science, EarlyView.
Since 1996, when the first glyphosate‐resistant crop was commercialized and the first resistant weed was reported, resistance has expanded globally. This review analyzes emergence patterns across weed species, crops, regions, resistance mechanisms, and herbicides.
Ricardo Alcántara‐de la Cruz, Yure Marin Guidi, Mariana Ramirez‐Castillo, Fernando Storniolo Adegas, Caio Antonio Carbonari, Edivaldo Domingues Velini, Rafael De Prado, Stephen O. Duke   +7 more
wiley   +1 more source

Larval antibiosis to cabbage stem flea beetle (Psylliodes chrysocephala) is absent within oilseed rape (Brassica napus)

Pest Management Science, EarlyView.
We screened a panel of 98 Brassicaceae genotypes (97 Brassica napus and 1 Sinapis alba) for cabbage stem flea beetle (Psylliodes chrysocephala) larval antibiosis. We found limited evidence for antibiosis across B. napus but consistent antibiosis in S. alba. Brassicaceae relatives may therefore better inform resistance traits for breeding.
Ryan E Brock, Clara Courtney, Steven Penfield, Rachel Wells   +3 more
wiley   +1 more source

Cell-type-specific and disease-associated expression quantitative trait loci in the human lung. [PDF]

Nat Genet
Natri HM, Del Azodi CB, Peter L, Taylor CJ, Chugh S, Kendle R, Chung MI, Flaherty DK, Matlock BK, Calvi CL, Blackwell TS, Ware LB, Bacchetta M, Walia R, Shaver CM, Kropski JA, McCarthy DJ, Banovich NE.   +17 more
europepmc   +1 more source

Long‐term impact of exposure to Royal Guard, a pyriproxyfen‐based bed net, on pyrethroid‐resistant malaria vectors from Cameroon using DNA‐based metabolic resistance markers

Pest Management Science, Volume 81, Issue 4, Page 2165-2180, April 2025.
We used recently detected P450 DNA‐based markers of pyrethroid resistance in both Anopheles funestus and Anopheles gambiae to demonstrate that although pyrethroid‐resistant mosquitoes have higher ability to survive and live longer after exposure to Royal Guard, this net significantly affects their lifespan, blood feeding ability and interestingly ...
Emilie S Ngongang‐Yipmo, Magellan Tchouakui, Benjamin D Menze, Riccado F Tiomela, Derrick Fofie, Vanessa B Ngannang‐Fezeu, Jean L Mugenzi, Flobert Njiokou, Charles S Wondji   +8 more
wiley   +1 more source

PancanQTLv2.0: a comprehensive resource for expression quantitative trait loci across human cancers. [PDF]

Nucleic Acids Res
Chen C, Liu Y, Luo M, Yang J, Chen Y, Wang R, Zhou J, Zang Y, Diao L, Han L.   +9 more
europepmc   +1 more source

Nanopore Electroporation: A New Delivery Method Within the Field of Epigenetic Editing

Small, EarlyView.
Nanopore‐mediated electroporation was used to deliver a CRISPRi system to clonal β‐cells. This enabled targeted downregulation of insulin expression while maintaining high cell viability. ABSTRACT Epigenetic modifications influence gene expression and contribute to type 2 diabetes (T2D), but establishing causality requires targeted modulation of ...
Frida Ekstrand, Sabrina Ruhrmann, Karl Bacos, Sabine Bartel, Pytrick Jellema, Marianne G. Rots, Charlotte Ling, Christelle N. Prinz   +7 more
wiley   +1 more source

Optimal variable identification for accurate detection of causal expression Quantitative Trait Loci with applications in heart-related diseases. [PDF]

Comput Struct Biotechnol J
Wang G, Zhang H, Shao M, Tian M, Feng H, Li Q, Cao C.   +6 more
europepmc   +1 more source