Results 101 to 110 of about 2,321,862 (234)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

An algebraic method to calculate parameter regions for constrained steady-state distribution in stochastic reaction networks

, 2018
Steady state is an essential concept in reaction networks. Its stability reflects fundamental characteristics of several biological phenomena such as cellular signal transduction and gene expression.
Hasegawa, Yoshihiko, Van Vu, Tan
core   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Synchronous solutions and their stability in nonlocally coupled phase oscillators with propagation delays

, 2010
We study the existence and stability of synchronous solutions in a continuum field of non-locally coupled identical phase oscillators with distance-dependent propagation delays.
Abhijit Sen, C. S. Peskin, Fatihcan M. Atay, Gautam C. Sethia, Y. Kuramoto, Y. Kuramoto   +5 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Identification and Validation of New Reference Genes for Normalization of Gene Expression in Flower and Berry Developmental Stages of Interspecific Grape Hybrid V. vinifera (L.) × V. labrusca (L.)

Journal of Horticultural Research
In quantitative reverse transcription polymerase chain reaction (qRT-PCR), normalizing target gene expression using a reference gene is an indispensable step to control the variability of RNA extraction yield, RNA integrity, reverse transcription ...
Chavan Siddhi, Khatal Anil, Phalake Satish, Tetali Sujata, Patil Ravindra   +4 more
doaj   +1 more source

Age-related changes in relative expression stability of commonly used housekeeping genes in selected porcine tissues

BMC Research Notes, 2011
Background Gene expression analysis using real-time RT-PCR (qRT-PCR) is increasingly important in biological research due to the high-throughput and accuracy of qRT-PCR. For accurate and reliable gene expression analysis, normalization of gene expression
Looft Christian, Tesfaye Dawit, Cinar Mehmet, Uddin Muhammad, Tholen Ernst, Schellander Karl   +5 more
doaj   +1 more source

ELM triggering conditions for the integrated modeling of H-mode plasmas

, 2004
Recent advances in the integrated modeling of ELMy H-mode plasmas are presented. A model for the H-mode pedestal and for the triggering of ELMs predicts the height, width, and shape of the H-mode pedestal and the frequency and width of ELMs. Formation of
A. H. Kritz, A. Y. Pankin, A.H. Glasser, A.M. Dimits, A.Y. Pankin, D. D. Schnack, D. P. Brennan, G. Bateman, G. Bateman, G. Janeschitz, G. Pacher, G. W. Pacher, G.M. Staebler, H. D. Pacher, H. Wilson, H.R. Wilson, I. Voitsekhovitch, J. Weiland, J.-S. Lönnroth, J.W. Connor, K.H. Burrell, L.L. Lao, M. Sugihara, M.S. Chance, O. Sauter, O.V. Zolotukhin, P. B. Snyder, P.B. Snyder, P.B. Snyder, P.N. Guzdar, P.N. Guzdar, R.L. Miller, S. Hamaguchi, S. Kruger, T. Onjun, T. Onjun, T. Onjun, T.H. Osborne, T.S. Hahm, T.S. Hahm, W. Horton, W.A. Houlberg, Y.B. Kim   +42 more
core   +1 more source

Stability and aggregation of ranked gene lists [PDF]

, 2009
Ranked gene lists are highly instable in the sense that similar measures of differential gene expression may yield very different rankings, and that a small change of the data set usually affects the obtained gene list considerably.
A.-L. Boulesteix, Aerts, Baldi, Boulesteix, Breitling, Eden, Fox, Gabrielsson, Ioannidis, Irizarry, Jeffery, Jha, Kooperberg, Kutalik, Lin, M. Slawski, Ma, Mukherjee, Pavlidis, Qiu, Stolovitzky, Strimmer, Strobl, Xu, Yang, Zintzaras   +25 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source