Results 51 to 60 of about 13,315 (175)

MetF‐Dependent Methionine Biosynthesis Is Required for Mycobacterium tuberculosis Survival and In Vivo Persistence

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
MetF is essential for both in vitro and in vivo growth of Mycobacterium tuberculosis, whereas MetE, previously considered essential in vitro, is dispensable in vivo. Given the importance of methionine and folate metabolism as drug targets, MetF represents a promising candidate, highlighting the need for in vivo validation.
Ikue Tosa, Tomoki Kitahara, Katsuki Takebe, Masaaki Nakayama, Yuko Ito, Akihito Nishiyama, Shintaro Seto, Hotaka Kawai, Hiharu Inoue, Yuki Fukada, Yuki Nishiya, Hitoshi Nagatsuka, Takayuki Wada, Manabu Ato, Sohkichi Matsumoto, Naoya Ohara   +15 more
wiley   +1 more source

Multidrug and extensively drug-resistant tuberculosis management: Evidences and controversies

Lung India, 2012
Multi-drug and extensively drug resistant tuberculosis (M/XDR-TB) has been an area of growing concern among clinicians, epidemiologists, and public health workers worldwide. Lack of controlled trials in M/XDR-TB patients hinders the optimal management of
R Prasad
doaj   +1 more source

Spatial heterogeneity of extensively drug resistant-tuberculosis in Western Cape Province, South Africa

Scientific Reports, 2022
Tuberculosis (TB) remains a leading infectious disease killer globally. Treatment outcomes are especially poor among people with extensively drug-resistant (XDR) TB, until recently defined as rifampicin-resistant (RR) TB with resistance to an ...
Karla Therese L. Sy, Sarah V. Leavitt, Margaretha de Vos, Tania Dolby, Jacob Bor, C. Robert Horsburgh, Robin M. Warren, Elizabeth M. Streicher, Helen E. Jenkins, Karen R. Jacobson   +9 more
doaj   +1 more source

Pathogenesis of Tuberculosis: Interplay Between Host Antituberculosis Immunity and Immune Evasion Strategies of Mycobacterium Tuberculosis

MedComm, Volume 7, Issue 8, August 2026.
Mycobacterium tuberculosis–host interactions and infection outcomes. Following initial infection, alveolar macrophages phagocytose the pathogen, prompting the recruitment of innate immune cells including neutrophils, NK cells, and interstitial macrophages.
Xiaojuan Zhang, Ying Liu, Yilin Hou, Hongxia Niu   +3 more
wiley   +1 more source

Molecular Characterization of Gram-Negative Bacteria: Antimicrobial Resistance, Virulence and Epidemiology

Antibiotics
Multidrug-resistant (MDR), extensively drug-resistant (XDR) and pan-drug-resistant (PDR) Gram-negative bacteria constitute a huge public health problem [...]
Theodoros Karampatakis
doaj   +1 more source

Case of Extensively Drug-Resistant Shigella sonnei Infection, United States

Emerging Infectious Diseases, 2023
We report extensively drug-resistant (XDR) Shigella sonnei infection in an immunocompromised patient in Texas, USA. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry failed to identify XDR Shigella, but whole-genome sequencing
Hosoon Choi, Dhammika H. Navarathna, Brennon L. Harston, Munok Hwang, Brandon Corona, Ma Rowen San Juan, Chetan Jinadatha   +6 more
doaj   +1 more source

EXTENSIVELY DRUG RESISTANT (XDR) SALMONELLA TYPHI RED FLAG FOR CLINICIANS AT KARACHI

Infectious Diseases Journal of Pakistan, 2023
Background: Salmonella typhi cause enteric fever which is a grave community health problem with increasing antibiotic resistance. Salmonella typhi is responsible for 10.9 million morbidities and 116800 mortalities worldwide with the greatest burden falling on third world countries.
Shaista Bakhat, Saman Nadeem, Ashfaq Hussain, Saba Sarwar, Beenish Hussain, Faisal Faheem   +5 more
openaire   +1 more source

Occurrence and Distribution of Environmental Pseudomonas aeruginosa From Hospitals in Bangladesh Reveals Diverse Strain Families, Multidrug Resistance, and Biofilm Formation

Environmental Microbiology Reports, Volume 18, Issue 4, August 2026.
Environmental reservoirs in Bangladeshi hospitals harbor phylogenetically diverse, multidrug‐resistant Pseudomonas aeruginosa with extensive biofilm‐forming capacity and class 1 integron‐associated resistance genes. These findings highlight hospital environments as persistent sources of antimicrobial resistance dissemination and underscore the need for
S. M. Kador, Tanay Chakrovarty, Khandaker Adil, Md. Mustak Ahmed, Md. Mohsin Kobir, Md. Hasanuzzaman, Mousufa Akter, Tanzima Sharmim Taowhid, Md. Tanvir Islam, Ovinu Kibria Islam   +9 more
wiley   +1 more source

Structure–Activity Relationship Analysis and hERG Liability Assessment of Second‐Generation Antibiofilm Compounds Active Against Salmonella

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Typhoid fever, caused by Salmonella enterica serovar Typhi, infects millions of individuals per year. Chronic carriage of typhoid fever is associated with biofilm formation in the gallbladder. Herein, we identify novel antibiofilm agents active against Salmonella enterica serovar Typhimurium.
Amy Sorge, Aliyah N. Bennett, Sophia E. Gregory, Allysa L. Cole, Katherine J. Woolard, Ansley M. Nemeth, Andrew H. Crow, Roberta J. Melander, John S. Gunn, Christian Melander   +9 more
wiley   +1 more source

A Comparative Policy Review of Tuberculosis Infection Control Policies Across Six Countries: Insights on Screening, Prevention, and Treatment Strategies

Health Science Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background and Aims Tuberculosis (TB) infection remains one of the major global public health challenges, disproportionately affecting vulnerable and marginalized populations. This study aims to compare prevention, screening, and treatment policies for TB in selected countries to identify effective strategies and policy gaps that may inform ...
Mohammad Veysi Sheikhrobat, Sajad Alizadeh, Kamal Shahamiri, Saeed Shahriari, Ahmad Tahmasebi‐Ghorrabi   +4 more
wiley   +1 more source