Results 61 to 70 of about 13,315 (175)

From Misinformation to Public Distrust: Urgency of Evidence‐Based Transparency, Communication and Community Engagement for Bangladesh's Typhoid Vaccination

Health Science Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background and Aims In Bangladesh, typhoid fever poses a significant threat to public health and has been a major epidemic for many years, especially affecting children from low‐ and middle‐income families due to poor water, sanitation, and seasonal living conditions.
Md. Salauddin, Antu Biswas
wiley   +1 more source

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, Volume 4, Issue 4, July 2026.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source

Incidence and Geographic Distribution of Extensively Drug-Resistant Tuberculosis in KwaZulu-Natal Province, South Africa.

PLoS ONE, 2015
South Africa is experiencing a widespread drug-resistant tuberculosis epidemic, although data are limited regarding the current situation. This study finds that the extensively drug-resistant tuberculosis (XDR-TB) incidence in KwaZulu-Natal increased to ...
Jennifer R Lim, Neel R Gandhi, Thuli Mthiyane, Koleka Mlisana, Julie Moodley, Prenika Jaglal, Neeshan Ramdin, James C M Brust, Nazir Ismail, Roxana Rustomjee, N Sarita Shah   +10 more
doaj   +1 more source

The First Documented Case of Congenital Drug‐Resistant Tuberculosis in Indonesia: A Case Report

Respirology Case Reports, Volume 14, Issue 7, July 2026.
This case presents the first documented instance of congenital rifampicin‐resistant tuberculosis (RR‐TB) in Indonesia, where a 32‐week preterm neonate exhibited non‐specific respiratory and sepsis‐like symptoms. After clinical deterioration and the identification of maternal TB, the diagnosis of congenital RR‐TB was confirmed through various tests ...
Cynthia Centauri, Srisadono Fauzi Adiprabowo, Putri Maharani Tristanita Marsubrin, Irandi Putra Pratomo   +3 more
wiley   +1 more source

Role of Gram‐Negative Bacterial Infections in Acute‐On‐Chronic Liver Failure

Liver International, Volume 46, Issue 7, July 2026.
ABSTRACT Acute‐on‐chronic liver failure (ACLF) is a systemic disease characterised by an acute clinical deterioration of pre‐existing liver cirrhosis leading to multiple organ failure due to systemic inflammation. It may be triggered by the translocation of bacteria and bacterial compounds across the gut barrier.
Camilla Cadoli, Volker Müller, Christoph Welsch, Heiko Mühl, Jonel Trebicka, Volkhard A. J. Kempf   +5 more
wiley   +1 more source

Antibiotics in Veterinary Ophthalmology: Resistance, Stewardship, and Emerging Antibiotic‐Sparing Strategies

Veterinary Ophthalmology, Volume 29, Issue 4, July 2026.
ABSTRACT Antimicrobial resistance (AMR) is a growing challenge in veterinary ophthalmology, particularly in cases of bacterial keratitis, where progressive stromal infection can threaten vision and globe integrity within hours to days. This review synthesizes current evidence on pathogen distribution, antimicrobial susceptibility profiles, multidrug ...
Lionel Sebbag, Oren Pe'er
wiley   +1 more source

Dual‐Peptide Nanoplatform: Mesoporous Silica Nanoparticles Functionalized With a Cell‐Penetrating Peptide and Loaded With Rationally Designed Antimicrobial Peptides for Tuberculosis Therapy

Advanced Healthcare Materials, Volume 15, Issue 21, 5 June 2026.
Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined
Christian S. Carnero Canales, Cesar Augusto Roque‐Borda, Ana Carolina Cerqueira Negri, Oswaldo Ramirez Delgado, Letícia Oliveira Catarin Nunes, Flávia Aparecida Resende, Hernane Barud, Norival Alves Santos‐Filho, Saulo Santesso Garrido, Karen Cristina Oliveira, Alexandra Ivo de Medeiros, Rafael Miguel Sábio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Whole genome sequencing-based characterization of extensively drug resistant (XDR) strains of Mycobacterium tuberculosis from Pakistan

International Journal of Mycobacteriology, 2015
Objectives: The global increase in drug resistance in Mycobacterium tuberculosis (MTB) strains increases the focus on improved molecular diagnostics for MTB.
Zahra Hasan, Asho Ali, Ruth McNerney, Kim Mallard, Grant Hill-Cawthorne, Francesc Coll, Mridul Nair, Arnab Pain, Taane G Clark, Rumina Hasan   +9 more
doaj   +1 more source

Automated Tuberculosis Detection in Chest Radiographs: A Hybrid Deep Learning Framework for Clinical Decision Support

Applied AI Letters, Volume 7, Issue 2, June 2026.
A hybrid deep learning framework integrating VGG16, ResNet50, and DenseNet121 is proposed for automated tuberculosis detection from chest X‐ray images. Feature‐level fusion enhances robustness and generalization, achieving 97.4% accuracy across multiple public datasets, supporting reliable clinical decision‐making in resource‐limited healthcare ...
Md. Tahmid Hossain, Hrittik Mural, Monowar Wadud Hridoy   +2 more
wiley   +1 more source

Assessing transporter‐mediated rifampin–linezolid interaction using physiologically‐based pharmacokinetic modelling

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1845-1856, June 2026.
Abstract Aims The study aims to develop a physiologically‐based pharmacokinetic (PBPK) model to quantitatively evaluate the role of ATP‐binding cassette sub‐family B member 1 (ABCB1) and ATP‐binding cassette super‐family G member 2 (ABCG2) in the drug–drug interaction (DDI) between rifampin and linezolid and to predict the impact of high‐dose rifampin ...
Hoang Dat Nguyen, Vinh Hoa Pham, Richard M. Hoglund, Joel Tarning, Junjie Ding   +4 more
wiley   +1 more source