Results 51 to 60 of about 379,899 (296)
European Psychiatry, 2020 Background In line with previous findings, in a recent randomized controlled trial (RCT), we found that home treatment (HT) for acute mental health care can reduce (substitute) hospital use among severely ill patients in crises.
N. Stulz +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
External Validity Reconsidered
, 2011 This chapter talks about the significance of generalizability. Experimentalists often go to great lengths to argue that student or other convenience samples are not problematic in terms of external validity.
Diana C. Mutz
core +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Estimating population average treatment effects from experiments with noncompliance
Journal of Causal Inference, 2020 Randomized control trials (RCTs) are the gold standard for estimating causal effects, but often use samples that are non-representative of the actual population of interest.
Ottoboni Kellie N., Poulos Jason V.
doaj +1 more source
Bridging the gap between the economics lab and the field: Dictator games and donations
Judgment and Decision Making, 2023 There is growing concern about the extent to which economic games played in the laboratory generalize to social behaviors outside the lab. Here, we show that it is possible to make a game much more predictive of field behavior by bringing contextual ...
Xinghua Wang, Daniel Navarro-Martinez
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Scientific Thinking About Legal Truth
Frontiers in Psychology, 2022 In the criminal process, the fact finders assess the validity of impressions reported by witnesses based on their perceptions and determine what has happened in reality. However, these impressions are not subject to any external validity check.
Gal Rosenzweig
doaj +1 more source