Results 61 to 70 of about 1,639,942 (291)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Scientific Thinking About Legal Truth

open access: yesFrontiers in Psychology, 2022
In the criminal process, the fact finders assess the validity of impressions reported by witnesses based on their perceptions and determine what has happened in reality. However, these impressions are not subject to any external validity check.
Gal Rosenzweig
doaj   +1 more source

Strength training for plantar fasciitis and the intrinsic foot musculature: A systematic review [PDF]

open access: yes, 2017
The aim was to critically evaluate the literature investigating strength training interventions in the treatment of plantar fasciitis and improving intrinsic foot musculature strength.
Clair, Mike   +3 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Sacrifice is a step beyond convenience: A review of convenience sampling in psychological research in Africa

open access: yesSA Journal of Industrial Psychology, 2021
Orientation: Articles from three African psychology journals were reviewed to indicate their use and reporting practices of convenience samples. Research purpose: Method-relevant sections of empirical research reports (qualitative, quantitative, mixed ...
Salome E. Scholtz
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Factors related to retention in a longitudinal study of infants at familial risk for autism

open access: yesJCPP Advances, 2023
Background Reporting retention data is critical to determining the soundness of a study's conclusions (internal validity) and broader generalizability (external validity).
Sally Ozonoff   +4 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Cooling trapped atoms in optical resonators [PDF]

open access: yes, 2007
We derive an equation for the cooling dynamics of the quantum motion of an atom trapped by an external potential inside an optical resonator. This equation has broad validity and allows us to identify novel regimes where the motion can be efficiently ...
Giovanna Morigi   +4 more
core   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

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