Results 11 to 20 of about 481,952 (302)
Macrophage Response Driven by Extracellular ATP
Biological and Pharmaceutical Bulletin, 2021 The purine nucleotide ATP is a fundamental unit in cellular energy metabolism. Extracellular ATP and its metabolites are also ligands for a family of receptors, known as purinergic receptors, which are expressed ubiquitously in almost every cell type.
Jing, Wang +2 more
openaire +3 more sources
Extracellular ATP signaling in plants [PDF]
Trends in Cell Biology, 2010 Extracellular adenosine-5′-triphosphate (ATP) induces a number of cellular responses in plants and animals. Some of the molecular components for purinergic signaling in animal cells appear to be lacking in plant cells, although some cellular responses are similar in both systems [e.g.
Tanaka, Kiwamu +3 more
openaire +3 more sources
Imaging extracellular ATP with a genetically-encoded, ratiometric fluorescent sensor. [PDF]
PLoS ONE, 2017 Extracellular adenosine triphosphate (ATP) is a key purinergic signal that mediates cell-to-cell communication both within and between organ systems. We address the need for a robust and minimally invasive approach to measuring extracellular ATP by re ...
Jason M Conley +3 more
doaj +1 more source
ATP is an essential autocrine factor for pancreatic β‐cell signaling and insulin secretion
Physiological Reports, 2022 ATP has been previously identified as an autocrine signaling factor that is co‐released with insulin to modulate and propagate β‐cell activity within islets of Langerhans.
Sebastian Hauke +4 more
doaj +1 more source
Excessive extracellular ATP desensitizes P2Y2 and P2X4 ATP receptors provoking surfactant impairment ending in ventilation-induced lung injury [PDF]
, 2018 Stretching the alveolar epithelial type I (AT I) cells controls the intercellular signaling for the exocytosis of surfactant by the AT II cells through the extracellular release of adenosine triphosphate (ATP) (purinergic signaling). Extracellular ATP is
Blankman, P. (Paul) +10 more
core +10 more sources
Molecules, 2022 Extracellular ATP exerts important functions as an extracellular signaling molecule via the activation of specific P2 purinergic receptors (P2X and P2Y).
Marco Rossato +9 more
doaj +1 more source
Frontiers in Neuroscience, 2022 Glutamate-induced neuroexcitotoxicity could be related to the pathophysiology of some neurodegenerative diseases including Parkinson’s disease and Alzheimer’s disease.
Yiping Xiong +5 more
doaj +1 more source
Ecto-nucleoside triphosphate diphosphohydrolase 2 modulates local ATP-induced calcium signaling in human HaCaT keratinocytes. [PDF]
PLoS ONE, 2013 Keratinocytes are the major building blocks of the human epidermis. In many physiological and pathophysiological conditions, keratinocytes release adenosine triphosphate (ATP) as an autocrine/paracrine mediator that regulates cell proliferation ...
Chia-Lin Ho +3 more
doaj +1 more source
Extracellular ATP and Neurodegeneration
Current Drug Target -CNS & Neurological Disorders, 2003 ATP is a potent signaling molecule abundantly present in the CNS. It elicits a wide array of physiological effects and is regarded as the phylogenetically most ancient epigenetic factor playing crucial biological roles in several different tissues. These can range from neurotransmission, smooth muscle contraction, chemosensory signaling, secretion and ...
Volonté, Cinzia +5 more
openaire +3 more sources
Extracellular ATP drives systemic inflammation, tissue damage and mortality [PDF]
, 2014 Systemic inflammatory response syndromes (SIRS) may be caused by both infectious and sterile insults, such as trauma, ischemia-reperfusion or burns. They are characterized by early excessive inflammatory cytokine production and the endogenous release of ...
Brouckaert, Peter +4 more
core +1 more source