Results 91 to 100 of about 236,767 (310)

Immunogenicity of Extracellular Vesicles

Advanced Materials
AbstractExtracellular vesicles (EVs) are promising next‐generation therapeutics and drug delivery systems due to demonstrated safety and efficacy in preclinical models and early‐stage clinical trials. There is an urgent need to address the immunogenicity of EVs (beyond the apparent lack of immunotoxicity) to advance clinical development.
Yutian Xia, Jianzhong Zhang, Gang Liu, Joy Wolfram   +3 more
openaire   +2 more sources

Cell Calcification Models and Their Implications for Medicine and Biomaterial Research

Advanced Healthcare Materials, EarlyView.
Calcification, is the process by which the tissues containing minerals are formed, occurring during normal physiological processes, or in pathological conditions. Here, it is aimed to give a comprehensive overview of the range of cell models available, and the approaches taken by these models, highlighting when and how methodological divergences arise,
Luke Hunter, Caterina Vanelli Coralli, Robert Dzhanaev, Aaron Morgan, Willi Jahnen‐Dechent, Sergio Bertazzo   +5 more
wiley   +1 more source

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

Ultrasound‐Triggered Gelation for Restoring Biomechanical Properties of Degenerated Functional Spinal Units

Advanced Healthcare Materials, EarlyView.
This study introduces an innovative approach to treating intervertebral disc degeneration using ultrasound‐triggered in situ hydrogel formation. Proof‐of‐concept experiments using optimized biomaterial and ultrasound parameters demonstrate partial restoration of biomechanical function and successful integration into degenerated disc tissue, offering a ...
Veerle A. Brans, Anna P. Constantinou, Matthew J. Kibble, Valeria Nele, Daniel Reumann, Luca Bau, Sebastien J. P. Callens, James P. K. Armstrong, Nicolas Newell, Constantin C. Coussios, Molly M. Stevens, Michael D. Gray   +11 more
wiley   +1 more source

From hope to healing: Exploring the therapeutic potential of exosomes in spinal cord injury

Extracellular Vesicle
Spinal cord injury (SCI) is the damage to the spinal cord causing paralysis below the injury site causing compromised patient life quality. Exosomes are nanosized vesicles released during physiological or pathological processes.
Nidhi Singh, Lahanya Guha, Hemant Kumar
doaj   +1 more source

Co‐Electrospinning Extracellular Matrix with Polycaprolactone Enables a Modular Approach to Balance Bioactivity and Mechanics of a Multifunctional Bone Wrap

Advanced Healthcare Materials, EarlyView.
The incorporation of nondigested ECM and synthetic polymers into a co‐electrospinning system enables the decoupling of bioactivity and mechanical properties within a single wrap. This technique is used to develop a multifunctional bone wrap that achieves augmented membrane durability, sustained infection control, and enhanced vascularity for use in ...
Sarah Jones, Madeline Laude, Zeenat Oyebanji, Ruchi Birur, Andres Luengo Martinez, Isabelle Gilbert, Phillip Baek, Nichole Longbottom, Nicole McCullough, Staci J. Horn, Chien‐Yu Lin, Matthew J. Lohr, Fred Clubb, Manuel K. Rausch, Elizabeth Cosgriff‐Hernandez   +14 more
wiley   +1 more source

Packaging of humanized anti-HER2 monoclonal antibody into small extracellular vesicles

Extracellular Vesicle
Small extracellular vesicles (sEVs), including exosomes and microvesicles (MVs), are nano-sized membranous particles shed by almost all cell types. Both play significant roles in cellular communication by transferring proteins, nucleic acids, lipids, and
Junxin Mai, Yuanmei Zhang, Zhixuan Liang, Wei Xu, Qian Shao, Jingwen Peng, Jing Chen, Yuting Shentu, Zixin Chen, Juling Ji, Yuhua Ji, Qiuling Xie   +11 more
doaj   +1 more source

Specific signatures of circulating extracellular vesicles emerged as novel biological tools for the detection of biomarkers for MCI and Alzheimer's disease [PDF]

, 2020
Charles Ramassamy
openalex   +1 more source

Dendritic cell extracellular vesicles

, 2019
In addition to direct cell-to-cell contact, dendritic cells (DCs) can regulate the onset of adaptive immunity through the secretion of nano-sized membrane structures, called extracellular vesicles (EVs). This novel mode of communication between cells has added a new layer of complexity to the regulation of immune responses.
Joanna, Kowal, Mercedes, Tkach
openaire   +3 more sources

Development of a Synthetic 3D Platform for Compartmentalized Kidney In Vitro Disease Modeling

Advanced Healthcare Materials, EarlyView.
A fully synthetic, compartmentalized 3D kidney disease model is introduced. The kidney model combines a PEG‐based hydrogel matrix with anisotropic, enzymatically degradable rod‐shaped microgels to spatially arrange a triple co‐culture of key renal epithelial, endothelial, and fibroblast cells.
Ninon Möhl, Daphne Bouwens, Johanna Abele, Aline Hans, Tanja Topic, Daniel Günther, Jitske Jansen, Rafael Kramann, Laura De Laporte   +8 more
wiley   +1 more source