Results 171 to 180 of about 1,588,316 (303)

Extracellular vesicles on the wire [PDF]

Cell Adhesion & Migration, 2017
Hyenne, Vincent, Goetz, Jacky
openaire   +2 more sources

Endothelial Cell Proteins as Biomarkers in Susac Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Susac syndrome (SS) is a rare CD8+ T cell–mediated microangiopathy affecting the brain, retina, and auditory labyrinth. Endothelial injury is thought to be a central mechanism; however, no circulating disease biomarkers are known. We performed targeted proteomic profiling to identify circulating endothelial‐associated proteins as ...
Rohit Benjamin, Yue Andy Qi, Ying Hao, Catherine DeMarino, Samuel Darko, Irene Cortese, Daniel S. Reich, María I. Gaitán, Steven Jacobson, Bridgett J. Billioux, Bryan Smith, Avindra Nath   +11 more
wiley   +1 more source

microRNA‐7‐5p and α‐Synuclein SAA Predict Parkinson's Disease Phenoconversion

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Corroborate blood neuron‐derived extracellular vesicle (NDEV) alpha‐synuclein (αSyn), the CSF αSyn seed amplification assay (αSyn‐SAA), and blood microRNA‐7‐5p (miR‐7‐5p) as markers for Parkinson's disease (PD) phenoconversion and determine if combining these markers would help select subjects who would be more likely to phenoconvert.
Shayan Zadegan, Praveen Velammal, Kanmani Muthiah, Madhu Jatty, Christopher Adams   +4 more
wiley   +1 more source

The Association of Amyloid‐β and Tau With Synaptic Dysfunction in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the relative contributions of amyloid and tau to synaptic dysfunction in Alzheimer's disease (AD). Methods We included 109 cognitively unimpaired and impaired individuals from the Geneva Memory Center with available CSF synaptic biomarkers (neurogranin, SNAP‐25, GAP‐43). Participants were stratified according to amyloid (A)
Fausto Roveta, Augusto J. Mendes, Valentina Garibotto, Cecilia Boccalini, Aurelien Lathuiliere, Innocenzo Rainero, Elisa Rubino, Henrik Zetterberg, Nicholas J. Ashton, Federica Ribaldi, Giovanni B. Frisoni, for the Alzheimer's Disease Neuroimaging Initiative   +11 more
wiley   +1 more source

Exosome therapy in female reproductive aging

Extracellular Vesicle
As life expectancy continues to extend, the adverse effects of reproductive aging on female health have become progressively conspicuous. Despite the extant focus on symptom alleviation, a paucity of pharmaceutical interventions addresses the underlying ...
Mengtong Zhang, Sichen Zhang, Shaowei Wang   +2 more
doaj   +1 more source

ATP‐Mediated Bidirectional Communication Between Natural and Artificial Cells for Controlled Bioreactions

Advanced Functional Materials, EarlyView.
Establishment of bidirectional communication behavior between natural and artificial cells. The first type of communication from natural dendritic cells to artificial polymeric cells was achieved via ATP release after cell lysis. The released ATP was taken up via gated UV‐controlled permeability increase of the polymeric membrane for performing ...
Ilona Kalte, Tsvetomir Ivanov, Leonhard Seufert, Shoupeng Cao, Lucas Caire da Silva, Volker Mailänder, Katharina Landfester   +6 more
wiley   +1 more source

Proteomic insights uncover enhanced neurotherapeutic potential in conditioned mesenchymal stem cell-derived extracellular vesicles

Extracellular Vesicle
Extracellular vesicles (EVs) show more potential as therapeutic agents for treating neurological disorders than their parent cells like MSCs. Notably, the therapeutic efficacy of MSCs can be boosted by inflammation factors and oxidative stressors.
Junxiu Xi, Tian Wang, Panpan Xian, Xiaoyan Liu, Minghao Du, Hao Yang, Perumal Palanisamy Chella, Wei Lin, Qianfa Long   +8 more
doaj   +1 more source

Dynamic Physicochemical Gradients for Tendon–Bone Regeneration

Advanced Functional Materials, EarlyView.
Dynamic physicochemical gradients offer a framework for reconnecting soft tendon and hard bone. This Review examines how hydration, transport, loading and degradation reshape these gradients during healing. Coordinating regional biological cues with progressive transfer of load from scaffold to tissue guides the design of interfaces that retain ...
Wanxue Wang, Minsheng Zhu, Junmiao Liu, Haowen Lu, Haoteng Wang, Yu Chen, Hua Liu, Zhengyu Xu, Zhiyong Sun, Huilin Yang, Yusen Qiao, Xia Zhao   +11 more
wiley   +1 more source

Exploring emerging concepts of exosomes for the diagnosis, prognosis, and therapeutics of brain cancers

Extracellular Vesicle
Brain cancers, a global menace with high mortality rates, remain a profound challenge, particularly in treating the most lethal type of malignant tumors like glioblastoma multiforme (GBM).
Subhrajyoti Banerjee, Vriti Sharma, Chitrangada Das Mukhopadhyay   +2 more
doaj   +1 more source

Protease‐Activated Theranostic Nanomedicine for Endometriosis Treatment

Advanced Functional Materials, EarlyView.
Endometriosis is a chronic gynecological disorder that affects a substantial proportion of reproductive‐aged women. In this study, we identify aberrant overexpression of matrix metalloproteinase‐9 (MMP‐9) in endometriotic lesions and develop a novel multifunctional nanomedicine that integrates MMP‐9‐targeted therapy, ratiometric photoacoustic (PA ...
Panangattukara Prabhakaran Praveen Kumar, Tae Hoon Kim, Hossein Hosseinirad, Maggie Lee, HyeJoo An, Bruce A. Lessey, Daniel Hanavi, Jung‐Ho Shin, Jae‐Wook Jeong, Taeho Kim   +9 more
wiley   +1 more source