Results 41 to 50 of about 201,537 (236)

Extracellular vesicles as novel therapeutic targets and diagnosis markers

Extracellular Vesicle, 2022
Extracellular vesicles (EVs) are membranous vesicles secreted from cells to the outside and are widely present in body fluids. The most commonly used method to isolate EVs is ultracentrifugation.
Yu Zhang, Weiliang Wu, Xiangbin Pan, Yanli Wang, Chengjie Wu, Lin Lu, Xi-Yong Yu, Yangxin Li   +7 more
doaj  

Migration of germline progenitor cells is directed by sphingosine-1-phosphate signalling in a basal chordate. [PDF]

, 2015
The colonial ascidian Botryllus schlosseri continuously regenerates entire bodies in an asexual budding process. The germ line of the newly developing bodies is derived from migrating germ cell precursors, but the signals governing this homing process ...
Bui, Connor, De Tomaso, Anthony W, Kassmer, Susannah H, Langenbacher, Adam D, Rodriguez, Delany   +4 more
core   +1 more source

Heparan sulfate proteoglycan-mediated internalization of extracellular vesicles ameliorates liver fibrosis by targeting hepatic stellate cells

Extracellular Vesicle, 2022
Accumulating evidence shows that stem cell-derived extracellular vesicles (EVs) have shown great promise for tissue regeneration and are considered an alternative to cell-based therapy.
Rongrong Li, Chen Wang, Manqian Zhou, Yue Liu, Shang Chen, Zihan Chai, Haoyan Huang, Kaiyue Zhang, Zhibo Han, Guoqiang Hua, Nadia Benkirane-Jessel, Zhong-Chao Han, Zongjin Li   +12 more
doaj  

The riddle of the plant vacuolar sorting receptors [PDF]

Protoplasma 226 (12/2005) 103-8, 2006
Proteins synthesized on membrane-bound ribosomes are sorted at the Golgi apparatus level for delivery to various cellular destinations: the plasma membrane or the extracellular space, and the lytic vacuole or lysosome. Sorting involves the assembly of vesicles, which preferentially package soluble proteins with a common destination.
arxiv   +1 more source

Nanoparticle Orientation to Control RNA Loading and Ligand Display on Extracellular Vesicles for Cancer Regression [PDF]

, 2018
Nanotechnology offers many benefits, and here we report an advantage of applying RNA nanotechnology for directional control. The orientation of arrow-shaped RNA was altered to control ligand display on extracellular vesicle membranes for specific cell ...
A Bunge, A Khaled, AK Varkouhi, B. Mark Evers, Bin Guo, C Pecot, CA Pettaway, Carlo M. Croce, CL Esposito, D Binzel, D Cui, D Jasinski, D Kumar, D Shu, D Shu, D Shu, Daniel W. Binzel, DW Binzel, F Haque, F Paduano, Farzin Haque, Fengmei Pi, H Valadi, H Zhang, HM Dongen van, Hui Li, I Pfeiffer, J Rak, JP Dassie, KV Kilchrist, L varez-Erviti, M Marcus, ME Hung, Meiyan Sun, MF Rimawi, N Parker, NE Hynes, OP Wiklander, P Guo, P Guo, P Guo, Peixuan Guo, Piotr Rychahou, S El Andaloussi, S El Andaloussi, S Ohno, SA Melo, Shaoying Wang, SM Dommelen van, Tae Jin Lee, TJ Lee, TN Lamichhane, WM Rockey, Y Li, Y Tian, Zhefeng Li   +55 more
core   +2 more sources

5‐Fluorouracil treatment represses pseudouridine‐containing miRNA export into extracellular vesicles

Journal of Extracellular Biology
5‐Fluorouracil (5‐FU) has been used for chemotherapy for colorectal and other cancers for over 50 years. The prevailing view of its mechanism of action is inhibition of thymidine synthase leading to defects in DNA replication and repair. However, 5‐FU is
Shimian Qu, Hannah M. Nelson, Xiao Liu, Yu Wang, Elizabeth M. Semler, Danielle L. Michell, Clark Massick, Jeffrey L. Franklin, John Karijolich, Alissa M. Weaver, Robert J. Coffey, Qi Liu, Kasey C. Vickers, James G. Patton   +13 more
doaj   +1 more source

Therapeutic and diagnostic potential of extracellular vesicles in amyotrophic lateral sclerosis

Extracellular Vesicle, 2023
As a late-onset and fatal neurodegenerative disease that affects upper and lower motor neurons, amyotrophic lateral sclerosis (ALS) is a difficult disease to diagnose and treat, needing further research on mechanisms of pathogenesis.
Taylor J. Ellison, Steven L. Stice, Yao Yao   +2 more
doaj  

Cell-to-Cell Communication in Learning and Memory: From Neuro- and Glio-Transmission to Information Exchange Mediated by Extracellular Vesicles [PDF]

, 2019
Most aspects of nervous system development and function rely on the continuous crosstalk between neurons and the variegated universe of non-neuronal cells surrounding them.
Di Liegro, Carlo Maria, Di Liegro, Italia, Schiera, Gabriella   +2 more
core   +1 more source

Computational analysis of serum-derived extracellular vesicle miRNAs in juvenile sheep model of single stage Fontan procedure

Extracellular Vesicle, 2022
Patients with single ventricle heart defects requires a series of staged open-heart procedures, termed Fontan palliation. However, while lifesaving, these operations are associated with significant morbidity and early mortality.
Hyun-Ji Park, John M. Kelly, Jessica R. Hoffman, Felipe Takaesu, William Schwartzman, Anudari Ulziibayar, Takahiro Kitsuka, Eric Heuer, Asigul Yimit, Raphael Malbrue, Cole Anderson, Adrienne Morrison, Aymen Naguib, Christopher Mckee, Andrew Harrison, Brian Boe, Aimee Armstrong, Arash Salavitabar, Andrew Yates, Toshiharu Shinoka, Sergio Carrillo, Christopher K. Breuer, Michael E. Davis   +22 more
doaj  

Multifunctional exosome-driven pancreatic cancer diagnostics and therapeutics

Extracellular Vesicle, 2023
Pancreatic cancer (PC) remains one of the most common causes of cancer death. The overall survival rate of PC is relatively low. PC frequently presents in patients with nonspecific symptoms at the localized stage and PC patients are mostly diagnosed at ...
Sitong Zhang, Danyang Li, Yingjia Liu, Chunlian Qin, Lingjun Tong, Lizhou Xu   +5 more
doaj