Molecular mechanisms that stabilize short term synaptic plasticity during presynaptic homeostatic plasticity. [PDF]
, 2018 Presynaptic homeostatic plasticity (PHP) compensates for impaired postsynaptic neurotransmitter receptor function through a rapid, persistent adjustment of neurotransmitter release, an effect that can exceed 200%.
Davis, Graeme W +2 more
core +1 more source
Dynamin-related protein 1 is required for normal mitochondrial bioenergetic and synaptic function in CA1 hippocampal neurons. [PDF]
, 2015 Disrupting particular mitochondrial fission and fusion proteins leads to the death of specific neuronal populations; however, the normal functions of mitochondrial fission in neurons are poorly understood, especially in vivo, which limits the ...
Berthet, A +12 more
core +7 more sources
Extracellular vesicles secreted by Schistosoma mansoni contain protein vaccine candidates [PDF]
, 2016 Herein we show for the first time that Schistosoma mansoni adult worms secrete exosome-like extracellular vesicles ranging from 50 to 130nm in size. Extracellular vesicles were collected from the excretory/secretory products of cultured adult flukes and ...
Becker, Luke +6 more
core +1 more source
NeuroEVs: Characterizing Extracellular Vesicles Generated in the Neural Domain. [PDF]
, 2019 Intercellular communication has recently been shown to occur via transfer of cargo loaded within extracellular vesicles (EVs). Present within all biofluids of the body, EVs can contain various signaling factors, including coding and noncoding RNAs (e.g.,
Fowler, Christie D
core
Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules [PDF]
, 2018 Background: Microenvironment cues involved in melanoma progression are largely unknown. Melanoma is highly influenced in its aggressive phenotype by the changes it determinates in its microenvironment, such as pH decrease, in turn influencing cancer cell
A Albini +67 more
core +10 more sources
Biophysical characterization of membrane phase transition profiles for the discrimination of Outer Membrane Vesicles (OMVs) from Escherichia coli grown at different temperatures [PDF]
arXiv, 2019 Dynamic Light Scattering (DLS), Small Angle X-ray Scattering (SAXS) and Transmission Electron Microscopy (TEM) are physical techniques widely employed to characterize the morphology and the structure of vesicles such as liposomes or human extracellular vesicles (exosomes). Bacterial extracellular vesicles are similar in size to human exosomes, although
arxiv
Protein Co-Enrichment Analysis of Extracellular Vesicles [PDF]
arXiv, 2023 Extracellular Vesicles (EVs) carry cell-derived proteins that confer functionality and selective cell uptake. However, whether proteins are packaged stochastically or co-enriched within individual EVs, and whether co-enrichment fluctuates under homeostasis and disease, has not been measured. EV abundance and protein global relative expression have been
arxiv
Tumor-derived microvesicles modulate antigen cross-processing via reactive oxygen species-mediated alkalinization of phagosomal compartment in dendritic cells [PDF]
, 2017 Dendritic cells (DCs) are the only antigen-presenting cells able to prime naïve T cells and cross-prime antigen-specific CD8+ T cells. Their functionality is a requirement for the induction and maintenance of long-lasting cancer immunity.
Aurelia Rughetti +16 more
core +2 more sources
Metastability of lipid necks via geometric triality [PDF]
arXiv, 2021 "Necks" are features of lipid membranes characterized by an uniquley large curvature, functioning as bridges between different compartments. These features are ubiquitous in the life-cycle of the cell and instrumental in processes such as division, extracellular vesicles uptake and cargo transport between organelles, but also in life-threatening ...
arxiv
Functional exploration of co-expression networks identifies a nexus for modulating protein and citric acid titres in Aspergillus niger submerged culture [PDF]
, 2019 Background: Filamentous fungal cell factories are used to produce numerous proteins, enzymes, and organic acids. Protein secretion and filamentous growth are tightly coupled at the hyphal tip. Additionally, both these processes require ATP and amino acid
Cairns, Timothy C. +6 more
core +1 more source