Results 61 to 70 of about 319,764 (352)

Extracellular Vesicles and Metastasis

Cold Spring Harbor Perspectives in Medicine, 2019
Secretion of cell contents through extracellular vesicles (EVs), such as exosomes and microvesicles, is a fundamental cell behavior. Compared with their normal counterparts, cancer cells are different in the amount and composition of EVs they secrete as a result of intrinsic and extrinsic (microenvironmental) alterations.
openaire   +4 more sources

Extracellular Vesicles—Connecting Kingdoms [PDF]

International Journal of Molecular Sciences, 2019
It is known that extracellular vesicles (EVs) are shed from cells of almost every type of cell or organism, showing their ubiquity in all empires of life. EVs are defined as naturally released particles from cells, delimited by a lipid bilayer, and cannot replicate. These nano- to micrometer scaled spheres shuttle a set of bioactive molecules.
Eric Woith, Gregor Fuhrmann, Matthias F. Melzig   +2 more
openaire   +3 more sources

Ultrasonication outperforms electroporation for extracellular vesicle cargo depletion

Extracellular Vesicle
Extracellular vesicles (EVs), submicron-sized membranous structures released by cells, serve as vehicles of tissue-specific proteins and nucleic acids, facilitating intercellular communication and playing roles in pathophysiological processes. Leveraging
Yundi Chen, Le Wang, Xu Yu, Wenjun Mao, Yuan Wan   +4 more
doaj   +1 more source

Plasma mEV levels in Ghanain malaria patients with low parasitaemia are higher than those of healthy controls, raising the potential for parasite markers in mEVs as diagnostic targets [PDF]

, 2019
© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The International Society for Extracellular Vesicles.
Antwi-Baffour, Samuel, Inal, Jameel, Jorfi, Samireh, Lange, Sigrun, Malibha-Pinchbeck, Memory, Stratton, Dan   +5 more
core   +5 more sources

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

An extracellular vesicle delivery platform based on the PTTG1IP protein

Extracellular Vesicle
Extracellular vesicles (EVs) are promising therapeutic delivery vehicles, although their potential is limited by a lack of efficient engineering strategies to enhance loading and functional cargo delivery.
Carla Martin Perez, Xiuming Liang, Dhanu Gupta, Emily R. Haughton, Mariana Conceição, Imre Mäger, Samir EL Andaloussi, Matthew J.A. Wood, Thomas C. Roberts   +8 more
doaj   +1 more source

Carbonic anhydrase inhibitor acetazolamide shifts synaptic vesicle recycling to a fast mode at the mouse neuromuscular junction [PDF]

, 2017
Acetazolamide (AZ), a molecule frequently used to treat different neurological syndromes, is an inhibitor of the carbonic anhydrase (CA), an enzyme that regulates pH inside and outside cells.
Bertone Cueto, Nicolás Iván, Cano, Raquel, Groisman, Ayelén Ivana, Mazzone, Graciela Luján, Tabares, Lucía, Uchitel, Osvaldo Daniel   +5 more
core   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Characterization of plasma-derived small extracellular vesicle miRNA and protein cargo in hereditary angioedema

Extracellular Vesicle
Hereditary angioedema (HAE) is an inherited disorder causing attacks of subcutaneous tissue or mucosa swelling. The disease burden and attack frequencies vary significantly among patients.
Linda Hofmann, Robin Lochbaum, Lutz Schütt, Ralph Röth, Stefanie Schmitteckert, Barbara Wollenberg, Thomas K. Hoffmann, Cornelia Brunner, Jens Greve, Janina Hahn, Marie-Nicole Theodoraki   +10 more
doaj   +1 more source

Fusion of secretory vesicles isolated from rat liver [PDF]

, 1978
Secretory vesicles isolated from rat liver were found to fuse after exposure to Ca2+. Vescle fusion is characterized by the occurrence of twinned vesicles with a continuous cleavage plane between two vesicles in freeze-fracture electron microscopy.
A. Amsterdam, A. Ichikawa, A. Lernmark, A.R. Poole, B. Hellman, B. Rose, C. Miller, C. Schudt, C. Schudt, C.M. Croge, D. Banerjee, D. Branton, D. Papahadjopoulos, D. Papahadjopoulos, D. Papahadjopoulos, D. Papahadjopoulos, D. Papahadjopoulos, E.K. Matthews, E.L. Pesanti, F. Malaisse-Lagae, G. Dahl, G. Dahl, G. Dahl, G. Poste, G. Virgilis De, G.M. Grodsky, G.R. Lawford, Gerhard Dahl, H. Schachter, J. Stadler, J.H. Ehrenreich, J.J.M. Bergeron, J.L. Mongar, J.S. Hong, L. Keay, L. Winquist, L.E. Hokin, M. Gratzl, M. Gratzl, M. Gratzl, M. Gratzl, M. Raiteri, M. Redman, M. Reporter, M.G. Farquar, Manfred Gratzl, N.A. Thorn, O. Stein, O.H. Lowry, P. Röhlich, P. Seeman, Q.F. Ahkong, R. Dipolo, R. Ekholm, R. Llinás, R. Miledi, R.C. Baker, R.D. Andrew, R.M. Case, R.P. Rubin, S.J. Burwen, T. Kanno, T. Maeda, T.Ch. Normann, W. Berger, W. Breisblatt, W. Breisblatt, W.W. Douglas, W.W. Douglas, W.W. Douglas, W.W. Douglas, W.W. Douglas, W.W. Douglas, W.W. Douglas, W.W. Douglas, Y. Marchand Le   +75 more
core   +1 more source