Results 61 to 70 of about 33,203 (242)

The interactions between extracellular vesicles and mesenchymal stem cells: Their potential roles in osteoarthritis development and cartilage repair

Extracellular Vesicle, 2022
Osteoarthritis (OA) is a chronic cartilage degeneration disease affecting total joint and with a wide global impact. Stem cell therapy has emerged as a potential stock for the treatment of OA.
Qiong Yang, Danyang Yue, Qian Ren, Guoqing Xia, Baihui Zhang, Yinyin Qin, Tianfei Ran, Min Wang, Li Pei, Jun Pan   +9 more
doaj  

Advanced glycation end products promote the release of endothelial cell‐derived mitocytosis

FEBS Open Bio, EarlyView.
Under diabetic conditions, AGEs induce mitochondrial damage in HUVECs, activating migrasome‐mediated mitocytosis. Migrasomes encapsulate damaged mitochondria and are released into the extracellular space, facilitating intercellular mitochondrial transfer.
Rong Liu, Yuhao Zhang, Tiantian Ge, Hao Wu, Yongbin Ma, Honghua Ye, Fei Guo   +6 more
wiley   +1 more source

Ultrasonication outperforms electroporation for extracellular vesicle cargo depletion

Extracellular Vesicle
Extracellular vesicles (EVs), submicron-sized membranous structures released by cells, serve as vehicles of tissue-specific proteins and nucleic acids, facilitating intercellular communication and playing roles in pathophysiological processes. Leveraging
Yundi Chen, Le Wang, Xu Yu, Wenjun Mao, Yuan Wan   +4 more
doaj  

PD-L1 antibodies-armed exosomal vaccine for enhanced cancer immunotherapy by simultaneously in situ activating T cells and blocking PD-1/PD-L1 axis

Extracellular Vesicle, 2022
Tumor immunotherapy significantly rewards antigen-specific T-cell responses, which have been recognized as the foundation of adaptive immune responses.
Xinyue Dai, Zhaoshuo Wang, Miao Fan, Huifang Liu, Xinjian Yang, Xueyi Wang, Xiaohan Zhou, Yunlu Dai, Jinchao Zhang, Zhenhua Li   +9 more
doaj  

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

An extracellular vesicle delivery platform based on the PTTG1IP protein

Extracellular Vesicle
Extracellular vesicles (EVs) are promising therapeutic delivery vehicles, although their potential is limited by a lack of efficient engineering strategies to enhance loading and functional cargo delivery.
Carla Martin Perez, Xiuming Liang, Dhanu Gupta, Emily R. Haughton, Mariana Conceição, Imre Mäger, Samir EL Andaloussi, Matthew J.A. Wood, Thomas C. Roberts   +8 more
doaj  

Complex RNA world in small extracellular vesicles for liquid biopsy in cancer management

Extracellular Vesicle, 2022
Liquid biopsy is a valuable tool in oncology with its advantages of non-invasiveness, longitudinal sampling, and capturing the intra- and inter-tumor heterogeneity. Small extracellular vesicles (sEVs) are released by cells into various biological fluids,
Shuhong Wang, Yusheng Lin, Yishi Zhang, Xiaofu Qiu, Yunlong Pan, Sai-Ching Jim Yeung, Hao Zhang   +6 more
doaj  

Extracellular matrix vesicles in human osteogenic neoplasms: An ultrastructural and enzymatic study [PDF]

, 1981
J. Sela, I. Bab, András Mühlrád, H Stein   +3 more
openalex   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Characterization of plasma-derived small extracellular vesicle miRNA and protein cargo in hereditary angioedema

Extracellular Vesicle
Hereditary angioedema (HAE) is an inherited disorder causing attacks of subcutaneous tissue or mucosa swelling. The disease burden and attack frequencies vary significantly among patients.
Linda Hofmann, Robin Lochbaum, Lutz Schütt, Ralph Röth, Stefanie Schmitteckert, Barbara Wollenberg, Thomas K. Hoffmann, Cornelia Brunner, Jens Greve, Janina Hahn, Marie-Nicole Theodoraki   +10 more
doaj