Results 81 to 90 of about 236,767 (310)

Drug‐Free Thrombolysis Mediated by Physically Activated Micro/Nanoparticles

Advanced Functional Materials, EarlyView.
Overview of particle‐mediated thrombolytic effects (thermal, mechanical, and chemical) and their activating physical stimuli (light, ultrasound, and magnetic field) in drug‐free thrombolysis. ABSTRACT Thrombus‐associated disorders rank among the world's leading causes of death, with ischemic heart disease and stroke as the main contributors.
Pierre Sarfati, Yoann Lalatonne, Cédric Chauvierre   +2 more
wiley   +1 more source

Exosome therapy in female reproductive aging

Extracellular Vesicle
As life expectancy continues to extend, the adverse effects of reproductive aging on female health have become progressively conspicuous. Despite the extant focus on symptom alleviation, a paucity of pharmaceutical interventions addresses the underlying ...
Mengtong Zhang, Sichen Zhang, Shaowei Wang   +2 more
doaj   +1 more source

Unraveling the Heterogeneity of Cargo Distribution in the Exogenous Association of Proteins With Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
We characterized the distribution of cargo proteins associated with extracellular vesicles using various exogenous loading methods. In all cases, single‐particle analysis revealed that the distribution of protein content per EV is heterogeneous, following an exponential decay function.
Karl Normak, Marcell Papp, Carolina Paganini, Andrea Zendrini, Paolo Bergese, Dorothea Pinotsi, Paolo Arosio   +6 more
wiley   +1 more source

Proteomic insights uncover enhanced neurotherapeutic potential in conditioned mesenchymal stem cell-derived extracellular vesicles

Extracellular Vesicle
Extracellular vesicles (EVs) show more potential as therapeutic agents for treating neurological disorders than their parent cells like MSCs. Notably, the therapeutic efficacy of MSCs can be boosted by inflammation factors and oxidative stressors.
Junxiu Xi, Tian Wang, Panpan Xian, Xiaoyan Liu, Minghao Du, Hao Yang, Perumal Palanisamy Chella, Wei Lin, Qianfa Long   +8 more
doaj   +1 more source

Extracellular vesicles from hypoxia-preconditioned mesenchymal stem cells alleviates myocardial injury by targeting thioredoxin-interacting protein-mediated hypoxia-inducible factor-1α pathway

, 2022
Chengyu Mao, Tiantian Zhang, Dongjiu Li, En Zhou, Yuqi Fan, Qing He, Changqian Wang, Junfeng Zhang   +7 more
openalex   +1 more source

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, EarlyView.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

Exploring emerging concepts of exosomes for the diagnosis, prognosis, and therapeutics of brain cancers

Extracellular Vesicle
Brain cancers, a global menace with high mortality rates, remain a profound challenge, particularly in treating the most lethal type of malignant tumors like glioblastoma multiforme (GBM).
Subhrajyoti Banerjee, Vriti Sharma, Chitrangada Das Mukhopadhyay   +2 more
doaj   +1 more source

Human blastocysts uptake extracellular vesicles secreted by endometrial cells containing miRNAs related to implantation

, 2023
Marina Segura-Benítez, Alba Bas-Rivas, Elena Juárez‐Barber, María Cristina Carbajo‐García, Amparo Faus, María José de los Santos, António Pellicer, Hortensia Ferrero   +7 more
openalex   +2 more sources

Membrane Vesicles from Lacticaseibacillus Casei BL23 Exhibit Antimicrobial Activity Against Escherichia coli and Immunostimulatory Effects on Human Peripheral Blood Mononuclear Cells

Advanced Healthcare Materials, EarlyView.
Membrane vesicles derived from the probiotic Lacticaseibacillus casei BL23 demonstrate antimicrobial properties against Escherichia coli and a potential biological effect in improving the overall survival of C. elegans infected with Pseudomonas aeruginosa. These vesicles stimulated immune responses in primary cells without causing toxicity. Our results
Cecilia L. D'Antoni, Leila Pourtalebi Jahromi, Lorenzo Sana, Ana Paula Domínguez Rubio, Maja Dorfner, Jennifer Munkert, Heike Danzer, Philipp Arnold, Mikhail Lebedev, Esther Zanin, Oscar E. Pérez, Gregor Fuhrmann   +11 more
wiley   +1 more source

Extracellular vesicles for breast cancer diagnosis and therapy

Extracellular Vesicle
Breast cancer is still suffering from its poor diagnosis and the lack of effective treatment. Despite of recent development of some novel chemicals, which are found to have inspiring therapeutic effects in vitro, their outcomes in clinic trails are ...
Jianan Shi, Huan Zhang, Yaxin Cui, Jianming Xing, Wei Wang, Jiayi Chen, Simiao Wang, Zhaogang Yang   +7 more
doaj   +1 more source