Results 171 to 180 of about 412,727 (336)

Lithium-doped calcium silicate cement regulates the immune microenvironment and promotes M2 macrophage polarization for enhancing bone regeneration

Journal of Biological Engineering
Bone defects present a significant challenge in orthopedics and trauma surgery, necessitating innovative approaches to stimulate effective bone regeneration. This study investigated the potential of lithium-doped calcium silicate (LiCS) cement to enhance
Yen-Hong Lin, Cheng-Yu Chen, Kun-Hao Chen, Ting-You Kuo, Tsung-Li Lin, Ming-You Shie   +5 more
doaj   +1 more source

Osteoimmunomodulation of astragalus-calcium silicate scaffolds-activated M2 macrophage-derived miR-218-rich exosome for enhanced bone regeneration

Materials Today Bio
Current therapeutic strategies for bone defects, including autografts, allografts, and conventional biomaterial scaffolds, are limited by donor site morbidity, immune rejection, and insufficient vascularization.
Cheng-Yu Chen, Jian-Jr Lee, Yen-Hong Lin, Ting-You Kuo, Der-Yang Cho, Ming-You Shie   +5 more
doaj   +1 more source

Mammalian cells in culture actively export specific microRNAs [PDF]

, 2009
The discovery of microRNAs (miRNAs) as a new class of regulators of gene expression has triggered an explosion of research, but has left many unanswered questions about how this regulation works and how it is integrated with other regulatory mechanisms ...
David Baxter, David J. Galas, Jessica Weber, Kai Wang, Shile Zhang   +4 more
core   +1 more source

Advances in Bioprinting to Model Immune‐Mediated Skin Diseases

Advanced Healthcare Materials, EarlyView.
This review explores how 3D bioprinting drives innovation in developing in vitro skin models that mimic immune‐mediated diseases. It highlights current technologies, key applications in studying skin pathologies, and emerging challenges. The review points toward future opportunities for improving disease modeling and advancing therapeutic and cosmetic ...
Andrea Ulloa‐Fernández, Marica Markovic, Julia Fernández‐Pérez, Georg Stary, Aleksandr Ovsianikov   +4 more
wiley   +1 more source

Therapeutic and diagnostic applications of extracellular vesicles [PDF]

, 2016
De Smedt, Stefaan, Raemdonck, Koen, Stremersch, Stephan   +2 more
core   +1 more source

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

Advanced Healthcare Materials, EarlyView.
This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement, Jana Ismail, Josefine Schroeder, Amod Godbole, Johanna Schreiber, Christine Weber, Zoltan Cseresnyes, Marc T. Figge, Bettina Löffler, Ulrich S. Schubert, Stephanie Schubert, Christina Ehrhardt, Carsten Hoffmann   +12 more
wiley   +1 more source

Endothelial cell-derived apoptotic bodies modulate innate and adaptive immune responses during inflammation

Cell Communication and Signaling
Endothelial cells (ECs) act as gatekeepers and signalling hubs that coordinate communication between blood vessels and surrounding tissues by regulating vascular tone, immune responses and numerous other physiological processes.
Caitlin L. Vella, Pamali Fonseka, Emma J. Grant, Stephanie F. Rutter, Donia Y. Abeid, Dilara C. Ozkocak, Tien K. Nguyen, Antony Vinh, Stephanie Paone, Grant R. Drummond, Christopher G. Sobey, Stephanie Gras, Mark D. Hulett, Suresh Mathivanan, Ivan K. H. Poon, Amy A. Baxter   +15 more
doaj   +1 more source

Extracellular Vesicles as Drug Carriers for Enzyme Replacement Therapy to Treat CLN2 Batten Disease: Optimization of Drug Administration Routes

, 2021
Matthew J. Haney, Y. Zhao, Y.S. Jin, E.V. Batrakova   +3 more
openalex   +1 more source

Mesenchymal Stem Cell‐Derived Apoptotic Micro‐Vesicles Repaired Sciatic Nerve Defect by Regulating Early Inflammatory Microenvironment and Promoting Angiogenesis

Advanced Healthcare Materials, EarlyView.
HUCMSC‐Apo‐mvs enhance peripheral nerve repair by modulating the inflammatory microenvironment (IME), primarily through coordinated actions on three functional cells. They recruit macrophages and promote their polarization from pro‐inflammatory M1 to anti‐inflammatory M2 phenotypes, increasing secretion of IL‐10 and VEGF.
Haolin Liu, Yiben Ouyang, Bo Wang, Xiaochun Zhang, Yanjun Guan, Ruichao He, Yuhui Cui, Junli Wang, Qianru Yao, Yixiao Tan, Xiwei Peng, Xing Xiong, Sice Wang, Dongdong Li, Haofeng Cheng, Tianqi Su, Xiaoyang Fu, Jinjuan Zhao, Mingqian Yu, Yi Wang, Jiang Peng, Yu Wang   +21 more
wiley   +1 more source

Extracellular Vesicles-ceRNAs as Ovarian Cancer Biomarkers: Looking into circRNA-miRNA-mRNA Code [PDF]

, 2022
Giuseppe Cammarata, Nadia Barraco, Ilaria Giusti, Valerio Gristina, Vincenza Dolo, Simona Taverna   +5 more
openalex   +1 more source