Results 171 to 180 of about 977,542 (369)

Proinflammatory cytokines sensitise mesenchymal stromal cells to apoptosis

Cell Death Discovery
Mesenchymal stromal cells (MSCs) exert broad therapeutic effects across a range of inflammatory diseases. Their mechanism of action has largely been attributed to paracrine signalling, orchestrated by an array of factors produced by MSCs that are ...
Natalie L. Payne, Swee Heng Milon Pang, Andrew J. Freeman, Dilara C. Ozkocak, Justin W. Limar, Georgia Wallis, Di Zheng, Senora Mendonca, Lorraine A. O’Reilly, Daniel H. D. Gray, Ivan K. H. Poon, Tracy S. P. Heng   +11 more
doaj   +1 more source

Isolation of Extracellular Vesicles: General Methodologies and Latest Trends

BioMed Research International, 2018
Background Extracellular vesicles (EVs) play an essential role in the communication between cells and transport of diagnostically significant molecules.
M. Konoshenko, E. Lekchnov, A. Vlassov, P. Laktionov   +3 more
semanticscholar   +1 more source

CNS Mitochondria‐Derived Vesicle in Blood: Potential Biomarkers for Brain Mitochondria Dysfunction

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial dysfunction is a hallmark of neurodegenerative diseases like Alzheimer's (AD) and Parkinson's (PD). Our goal was to develop practical, noninvasive methods to assess mitochondrial status through the detection of mitochondria‐derived vesicles (MDVs).
Qi Liu, Wentao Chen, Yahong Wu, Zhen Guo, Jun Chen, Chen Tian, Pan Wang, Shaopeng Zeng, Bin Xu, Jing Duan, Shilong Han, Xiao Xiong, Jing Zhang   +12 more
wiley   +1 more source

Artificial Receptor in Synthetic Cells Performs Transmembrane Activation of Proteolysis

Advanced Biology, EarlyView.
Transmembrane signaling is the hallmark of living cells and is among the highest challenges for the design of synthetic cells. Herein, an artificial receptor based on the chemistry of self‐immolative linkers is used to communicate information across the lipid bilayer, for transmembrane activation of enzymatic activity. Abstract The design of artificial,
Ane Bretschneider Søgaard, Kaja Borup Løvschall, Mireia Casanovas Montasell, Clara Bakkegaard Cramer, Pere Monge Marcet, Andreas Bøtker Pedersen, Josefine Hammer Jakobsen, Alexander N. Zelikin   +7 more
wiley   +1 more source

Rapid Trapping and Label-free Characterization of Single Nanoscale Extracellular Vesicles and Nanoparticles in Solution [PDF]

arXiv
Achieving high-throughput, comprehensive analysis of single nanoparticles to determine their size, shape, and composition is essential for understanding particle heterogeneity with applications ranging from drug delivery to environmental monitoring.
arxiv  

Comprehensive isolation of extracellular vesicles and nanoparticles

Nature Protocols, 2023
Qin Zhang, Dennis K. Jeppesen, J. Higginbotham, J. Franklin, R. Coffey   +4 more
semanticscholar   +1 more source

Spatiotemporal Control Over Protein Release from Artificial Cells via a Light‐Activatable Protease

Advanced Biology, EarlyView.
Stimulus‐responsive protein release is essential for intercellular communication. Mimicking this functionality in artificial cells is promising to study the working principles of cellular signaling. Herein, an engineered light‐activatable protease is implemented in a coacervate‐based artificial cell platform to establish user‐defined spatiotemporal ...
Arjan Hazegh Nikroo, Wiggert J. Altenburg, Thijs W. van Veldhuisen, Luc Brunsveld, Jan C. M. van Hest   +4 more
wiley   +1 more source

Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy

Nature Biomedical Engineering, 2023
Yi You, Yu Tian, Zhaogang Yang, Junfeng Shi, K. Kwak, Yuhao Tong, Andreanne Poppy Estania, Jianhong Cao, Wei-Hsiang Hsu, Yutong Liu, Chi-Ling Chiang, B. Schrank, Kristin M. Huntoon, DaeYong Lee, Zi-Xin Li, Yarong Zhao, Huan Zhang, Thomas D Gallup, Jonghoon Ha, Shiyan Dong, Xuefeng Li, Yifan Wang, Wen-jing Lu, Eman Bahrani, L. Lee, Lesheng Teng, Wen Jiang, Feng Lan, Betty Y. S. Kim, Andrew S. Lee   +29 more
semanticscholar   +1 more source

Light‐Triggered Protease‐Mediated Release of Actin‐Bound Cargo from Synthetic Cells

Advanced Biology, EarlyView.
TEV Prtoease‐mediated Releasable Actin‐binding Protein (TRAP) is a protein‐based platform consisting of a cargo tightly bound to reconstituted actin networks in synthetic cells which can be proteolyticly released from the bound actin, followed by its secretion through membrane translocation mediated by a cell‐penetrating peptide.
Mousumi Akter, Hossein Moghimianavval, Gary D. Luker, Allen P. Liu   +3 more
wiley   +1 more source

An aggregation-induced emission-active lysosome hijacker: Sabotaging lysosomes to boost photodynamic therapy efficacy and conquer tumor therapeutic resistance

Materials Today Bio
Therapeutic resistance is a major challenge in clinical cancer theranostics, often leading to treatment failure and increased patient mortality. Breaking this therapeutic deadlock, enhancing the efficacy of clinical treatments, and ultimately improving ...
Hang Zou, Pingping Wang, Zhihao Bai, Liping Liu, Jingtong Wang, Yanfang Cheng, Bairong He, Zujin Zhao, Lei Zheng   +8 more
doaj