Results 111 to 120 of about 23,129 (240)
Neurobiology of Disease, 2012 We recently reported evidence for disturbed synaptic versus extrasynaptic NMDAR transmission in the early pathogenesis of Huntington's disease (HD), a late-onset neurodegenerative disorder caused by CAG repeat expansion in the gene encoding huntingtin ...
Austen J. Milnerwood +12 more
doaj +1 more source
DMV extrasynaptic NMDA receptors regulate caloric intake in rats
JCI Insight, 2021 Acute high-fat diet (aHFD) exposure induces a brief period of hyperphagia before caloric balance is restored. Previous studies have demonstrated that this period of regulation is associated with activation of synaptic N-methyl-D-aspartate (NMDA ...
Courtney Clyburn +3 more
doaj +1 more source
Ketamine: NMDA receptors and beyond [PDF]
, 2016 Human studies examining the effects of the dissociative anesthetic ketamine as a model for psychosis and as a rapidly acting antidepressant have spurred great interest in understanding ketamine's actions at molecular, cellular, and network levels ...
Izumi, Yukitoshi +2 more
core +2 more sources
Amyloid Beta in Alzheimer's Disease: Mechanisms, Biomarker Potential, and Therapeutic Targets
CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.The limited clinical efficacy of anti‐Aβ antibodies has challenged the Aβ hypothesis, compelling the integration of key mechanisms—including neuroinflammation, mitochondrial dysfunction, oxidative stress, and post‐translational modifications of Aβ—into a revised model of Alzheimer's disease.
Shamseddin Ahmadi +3 more
wiley +1 more source
Frontiers in Physiology, 2012 Persistent peripheral inflammation changes AMPA receptor (AMPAR) trafficking in dorsal horn neurons by promoting internalization of GluR2-containing, Ca2+-impermeable AMPARs from the synapses and by increasing insertion of GluR1-containing, Ca2 ...
Olga eKopach +3 more
doaj +1 more source
Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes [PDF]
, 2015 BACKGROUND: GABAA receptor subunit composition has a profound effect on the receptor's physiological and pharmacological properties. The receptor β subunit is widely recognised for its importance in receptor assembly, trafficking and post-translational ...
Smart, TG, Villumsen, IS, Wellendorph, P
core +1 more source
Frontiers in Physiology, 2012 Communication between neurons is achieved by rapid signal transduction via highly specialized structural elements known as synaptic contacts. In addition, numerous extrasynaptic mechanisms provide a flexible platform for the local regulation of synaptic ...
Olivier eCamiré +2 more
doaj +1 more source
NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content
Cell Reports, 2019 Summary: In mature neurons, postsynaptic N-methyl-D-aspartate receptors (NMDARs) are segregated into two populations, synaptic and extrasynaptic, which differ in localization, function, and associated intracellular cascades. These two pools are connected
Andrew M. Chiu +6 more
doaj +1 more source
NMDARs in Alzheimer's Disease: Between Synaptic and Extrasynaptic Membranes. [PDF]
Int J Mol SciN-methyl-D-aspartate receptors (NMDARs) are glutamate receptors with key roles in synaptic communication and plasticity. The activation of synaptic NMDARs initiates plasticity and stimulates cell survival. In contrast, the activation of extrasynaptic NMDARs can promote cell death underlying a potential mechanism of neurodegeneration occurring in ...
Escamilla S +2 more
europepmc +5 more sources
Acetylcholine receptors in regenerating muscle accumulate at original synaptic sites in the absence of the nerve. [PDF]
, 1979 We examined the role of nerve terminals in organizing acetylcholine receptors on regenerating skeletal-muscle fibers. When muscle fibers are damaged, they degenerate and are phagocytized, but their basal lamina sheaths survive.
Burden, SJ, McMahan, UJ, Sargent, PB
core