Results 181 to 190 of about 12,419 (203)
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Synaptic and Extrasynaptic Secretion of Serotonin
Cellular and Molecular Neurobiology, 2005Serotonin is a major modulator of behavior in vertebrates and invertebrates and deficiencies in the serotonergic system account for several behavioral disorders in humans. The small numbers of serotonergic central neurons of vertebrates and invertebrates produce their effects by use of two modes of secretion: from synaptic terminals, acting locally in "
Citlali Trueta, Francisco F. De-Miguel
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Extrasynaptic GABA and Glutamate Receptors in Epilepsy
CNS & Neurological Disorders - Drug Targets, 2007Epilepsy is a neurological disorder in which normal brain function is disrupted as a consequence of intensive and synchronous burst activity from neuron assemblies. Epilepsies result from long-lasting plastic changes in the brain affecting neurotransmitter release, the properties of receptors and channels, synaptic reorganization and astrocyte activity.
Germán Sierra-Paredes +1 more
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Trends in Neurosciences, 1979
Abstract Receptors and membrane carriers for the central inhibitory transmitter γ-aminobutyric acid (GABA) are not confined to the central nervous system. This article examines the extrasynaptic components of the GABA-system in the mammalian peripheral nervous system and suggests how they help to understand some aspects of gabanergic function in the ...
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Abstract Receptors and membrane carriers for the central inhibitory transmitter γ-aminobutyric acid (GABA) are not confined to the central nervous system. This article examines the extrasynaptic components of the GABA-system in the mammalian peripheral nervous system and suggests how they help to understand some aspects of gabanergic function in the ...
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Nanostructured Antagonist of Extrasynaptic NMDA Receptors
Nano Letters, 2016Glutamatergic cytotoxicity mediated by overactivation of N-methyl-d-aspartate receptors (NMDARs) is implicated in numerous neurological disorders. To be therapeutically viable, NMDAR antagonists must preserve physiological role of synaptic NMDARs (sNMDARs) in synaptic transmission and block only excessive pathological activation of NMDARs.
Alex Savchenko +3 more
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2014
γ-aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the brain and its actions are mediated by two diverse families of neurotransmitter receptors, the ionotropic receptors, known as GABAA receptors, and metabotropic receptors that are classified as GABAB receptors.
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γ-aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the brain and its actions are mediated by two diverse families of neurotransmitter receptors, the ionotropic receptors, known as GABAA receptors, and metabotropic receptors that are classified as GABAB receptors.
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Synaptic and Extrasynaptic Glutamate Signaling in Ischemic Stroke
Current Medicinal Chemistry, 2014Stroke is a leading cause of human mortality and disability where most cases of stroke are ischemic. The central nervous system (CNS) is extremely vulnerable to ischemic stroke particularly due to its unique ability: synaptic transmission. Not only does elaborate synaptic transmission consume extravagant energy that constrains neuronal viability under ...
Naijian Chao, Sheng-Tian Li
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Extrasynaptic distribution of monoamine transporters and receptors
2000Publisher Summary Extra-synaptic, as well as synaptic sites for monoaminergic transmission have been elucidated by using electron microscopic immunocytochemistry for the localization of sequence specific antipeptide antisera against recently cloned vesicular and plasmalemmal monoamine transporters and receptors.
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