Reduction of the Ca<sup>2+</sup> permeability of ligand-gated ion channels as a strategy against excitotoxicity. [PDF]
Front Cell NeurosciD'Andrea T, Fucile S.
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AMPA receptor diffusional trapping machinery as an early therapeutic target in neurodegenerative and neuropsychiatric disorders. [PDF]
Transl NeurodegenerChoquet D, Opazo P, Zhang H.
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Recurrent neonatal seizures increase tonic inhibition and respond to enhancers of δ-containing GABAA receptors. [PDF]
JCI InsightLiddiard GT +3 more
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Time-dependent adaptations of damaged neurons and their microenvironment in the regenerating adult zebrafish spinal cord. [PDF]
Sci AdvLafouasse L +7 more
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From Stumbling Blocks to Stepping Stones: Progress in Treating Temporal Lobe Epilepsy With Stem Cell Transplantation. [PDF]
Epilepsy CurrNaegele JR.
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Synaptic and extrasynaptic neuron-glia interactions
Opera Medica et Physiologica, 2016 openaire +1 more source
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Nano Letters, 2016Glutamatergic cytotoxicity mediated by overactivation of N-methyl-d-aspartate receptors (NMDARs) is implicated in numerous neurological disorders. To be therapeutically viable, NMDAR antagonists must preserve physiological role of synaptic NMDARs (sNMDARs) in synaptic transmission and block only excessive pathological activation of NMDARs.
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Abstract Receptors and membrane carriers for the central inhibitory transmitter γ-aminobutyric acid (GABA) are not confined to the central nervous system. This article examines the extrasynaptic components of the GABA-system in the mammalian peripheral nervous system and suggests how they help to understand some aspects of gabanergic function in the ...
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