Results 181 to 190 of about 22,128 (213)

Recruiting Extrasynaptic NMDA Receptors Augments Synaptic Signaling

Journal of Neurophysiology, 2008
N-Methyl-d-aspartate receptor (NMDAR) activation may promote cell survival or initiate cell death, with the outcome dependent on whether synaptic or extrasynaptic receptors are activated. Similarly, this differential activation has been proposed to govern the direction of plasticity.
Alexander Z, Harris, Diana L, Pettit
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Dispersing Extrasynaptic Clusters

Science's STKE, 2005
Prior to formation of the neuromuscular junction, clusters of acetylcholine receptors (AChRs) form a band in the central region of the muscle fiber; with innervation, nascent AChRs become stabilized in the muscle membrane underlying the nerve terminal but disperse elsewhere.
openaire   +1 more source

Extrasynaptic NMDA Receptors Reshape Gene Ranks

Science's STKE, 2007
The N -methyl-D-aspartate (NMDA) subtype of glutamate receptors (NMDAR) plays a key role in the control of neuronal plasticity and cell survival by modifying the activity of different signaling pathways and numerous genes.
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Synaptic and Extrasynaptic Glutamate Signaling in Ischemic Stroke

Current Medicinal Chemistry, 2014
Stroke is a leading cause of human mortality and disability where most cases of stroke are ischemic. The central nervous system (CNS) is extremely vulnerable to ischemic stroke particularly due to its unique ability: synaptic transmission. Not only does elaborate synaptic transmission consume extravagant energy that constrains neuronal viability under ...
Naijian, Chao, Sheng-Tian, Li
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Mechanism of extrasynaptic dopamine signaling in Caenorhabditis elegans

Nature Neuroscience, 2004
D1-like and D2-like dopamine receptors have synergistic and antagonistic effects on behavior. To understand the mechanisms underlying these effects, we studied dopamine signaling genetically in Caenorhabditis elegans. Knocking out a D2-like receptor, DOP-3, caused locomotion defects similar to those observed in animals lacking dopamine.
Daniel L, Chase, Judy S, Pepper, Michael R, Koelle   +2 more
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NMDA receptor autoantibodies primarily impair the extrasynaptic compartment

Brain
Abstract Autoantibodies directed against the N-methyl-D-aspartate receptor (NMDAR-Ab) are pathogenic immunoglobulins detected in patients suffering from NMDAR encephalitis. NMDAR-Ab alter the receptor membrane trafficking, synaptic transmission and neuronal network properties, leading to neurological and psychiatric symptoms in patients.
Laurent Groc, Harald Prüss, Delphine Bouchet   +2 more
exaly   +4 more sources

Regulation of Excitability by Extrasynaptic GABAA Receptors

2007
Not only are GABA(A) receptors activated transiently by GABA released at synapses, but high affinity, extrasynaptic GABA(A) receptors are also activated by ambient, extracellular GABA as a more persistent form of signalling (often termed tonic inhibition).
Matthew C, Walker, Alexey, Semyanov
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Diffusional extrasynaptic neurotransmission via glutamate and GABA

Neuroscience and Behavioral Physiology, 2005
Glutamate and GABA are the main synaptic neurotransmitters in the hippocampus. However, their actions are not limited only to the local postsynaptic zone. These amino acids can be released into the extrasynaptic space by glutamate and GABA reuptake, glial exocytosis, osmotic shock, and spillover (flowing out of the synaptic cleft).
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NMDARs in Alzheimer’s Disease: Between Synaptic and Extrasynaptic Membranes

International Journal of Molecular Sciences
N-methyl-D-aspartate receptors (NMDARs) are glutamate receptors with key roles in synaptic communication and plasticity. The activation of synaptic NMDARs initiates plasticity and stimulates cell survival. In contrast, the activation of extrasynaptic NMDARs can promote cell death underlying a potential mechanism of neurodegeneration occurring in ...
Inmaculada Cuchillo-Ibañez
exaly   +5 more sources

Neurosteroids and Extrasynaptic GABAA Receptors

2014
Steroid sex hormones are generally thought to act through intracellular receptors, where they regulate gene expression and protein synthesis, an effect that takes minutes to hours to occur. However, steroid metabolites can also directly modulate the activity of numerous ligand-gated ion channels. These metabolites can be synthesised de novo in the CNS,
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