Results 161 to 170 of about 15,145 (185)

Neurosteroid modulation of synaptic and extrasynaptic GABAA receptors

Pharmacology & Therapeutics, 2007
Certain naturally occurring pregnane steroids act in a nongenomic manner to potently and selectively enhance the interaction of the inhibitory neurotransmitter GABA with the GABA(A) receptor. Consequently such steroids exhibit anxiolytic, anticonvulsant, analgesic, sedative, hypnotic, and anesthetic properties.
Herd, Murray B., Belelli, Delia, Lambert, Jeremy J.   +2 more
openaire   +3 more sources

The Pharmacology of Extrasynaptic GABAA Receptors

2014
The different subunits that make up the family of GABAA receptor subtypes have unique distributions within the brain and nervous system. Their localization at the neuronal level is in many cases not necessarily associated with synaptic densities, and this has led to the hypothesis that extrasynaptic receptors perform a unique function in controlling ...
openaire   +1 more source

Synaptic and Extrasynaptic Mitochondria

2022
Vitória Girelli de Oliveira, Jijo Stebin Justus, Luis Valmor Cruz Portela, Marcelo Salimen Rodolphi   +3 more
openaire   +1 more source

Extrasynaptic NMDA Receptors Reshape Gene Ranks

Science's STKE, 2007
The N -methyl-D-aspartate (NMDA) subtype of glutamate receptors (NMDAR) plays a key role in the control of neuronal plasticity and cell survival by modifying the activity of different signaling pathways and numerous genes.
openaire   +2 more sources

Neurosteroids and Extrasynaptic GABAA Receptors

2014
Steroid sex hormones are generally thought to act through intracellular receptors, where they regulate gene expression and protein synthesis, an effect that takes minutes to hours to occur. However, steroid metabolites can also directly modulate the activity of numerous ligand-gated ion channels. These metabolites can be synthesised de novo in the CNS,
openaire   +1 more source

The neuronal primary cilium—an extrasynaptic signaling device

Cellular Signalling, 2004
Many, but likely most, neurons in the central nervous system have a nonmotile "primary" cilium extending like an antenna or finger from one of the pair of centrioles in the cell's centrosome into the extracellular space. Since their discovery over 100 years ago, these organelles have been either dismissed as functionless relicts of a bygone era or more
openaire   +2 more sources

Extrasynaptic GABAA Receptors

2014
openaire   +2 more sources

A novel method using ambient glutamate for the electrophysiological quantification of extrasynaptic NMDA receptor function in acute brain slices

Journal of Physiology, 2020
C Peter Bengtson, Hilmar Bading, Joachim Bèhr   +2 more
exaly  

Extrasynaptic receptors and parasynaptic communication in the brain

Brain Research Bulletin, 1999
openaire   +2 more sources

People also looked at

Frontiers in Physiology, 2012
Citlali Trueta, Francisco F De-Miguel
exaly   +2 more sources