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A Role for Extrasynaptic GABA Receptors?
Science's STKE, 2004Proper brain function depends on maintaining an appropriate balance between excitation and inhibition: Tipping the balance too far toward inhibition leads to sedation, whereas tipping it too far toward excitation can trigger a seizure. Although research on the role of γ aminobutyric acid (GABA, the chief inhibitory neurotransmitter) in ...
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The neuronal primary cilium—an extrasynaptic signaling device
Cellular Signalling, 2004Many, but likely most, neurons in the central nervous system have a nonmotile "primary" cilium extending like an antenna or finger from one of the pair of centrioles in the cell's centrosome into the extracellular space. Since their discovery over 100 years ago, these organelles have been either dismissed as functionless relicts of a bygone era or more
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Synaptic and Extrasynaptic Mitochondria
2022Vitória Girelli de Oliveira +3 more
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The Pharmacology of Extrasynaptic GABAA Receptors
2014The different subunits that make up the family of GABAA receptor subtypes have unique distributions within the brain and nervous system. Their localization at the neuronal level is in many cases not necessarily associated with synaptic densities, and this has led to the hypothesis that extrasynaptic receptors perform a unique function in controlling ...
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Mechanisms of inhibition and activation of extrasynaptic αβ GABAA receptors
Nature, 2022Vikram Babu Kasaragod +2 more
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Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
Nature Neuroscience, 2002Giles E Hardingham, Hilmar Bading
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Synaptic and Extrasynaptic NMDA Receptors Are Gated by Different Endogenous Coagonists
Cell, 2012Thomas Papouin +2 more
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