Results 101 to 110 of about 13,969 (210)
Inhibition of Fatty Acid Amide Hydrolase (FAAH) by Macamides
The FASEB Journal, 2018 Purpose Pentane extract of the Peruvian plant Lepidium meyenii (Maca) has been demonstrated to possess neuroprotective activity in previous studies. This extract contains several macamides that might act on the endocannabinoid system.
M. Alasmari +4 more
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The anti-inflammatory and analgesic potential of the probiotic Streptococcus thermophilus via inhibition of endocannabinoid-degrading enzymes: a preliminary in vitro study [PDF]
Exploration of ImmunologyAim: The benefit of topical application of probiotics on pain and itching associated with skin disorders has become an increasingly intriguing topic in recent years.
Serena Altamura +7 more
doaj +1 more source
TRPV1–FAAH–COX: The Couples Game in Pain Treatment
ChemMedChem, 2016 AbstractPain is a complex sensation involving the perception and transduction of diverse environmental pain stimuli with cognitive and emotional processing by the central nervous system. It can manifest as acute or chronic pain. Pain is controlled by a series of enzymes and receptors, implicated in a variety of interconnected mechanisms and pathways ...
Aiello, Francesca +3 more
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Journal of Lipid Research, 2004 We investigated the formation of PGF2α 1-ethanolamide, PGE2 1-ethanolamide, and PGD2 1-ethanolamide (prostamides F2α, E2, and D2, respectively) in liver, lung, kidney, and small intestine after a single intravenous bolus administration of 50 mg/kg of ...
Allan Weber +7 more
doaj +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Inhibition of fatty acid amide hydrolase (FAAH) reduces the gastrointestinal damage produced by non-steroidal anti-inflammatory agents such as sulindac and indomethacin in experimental animals, suggesting that a dual-action FAAH-cyclooxygenase (COX ...
Alessandro Deplano +6 more
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Endocannabinoid Hydrolase Inhibitors: Potential Novel Anxiolytic Drugs
Drug Design, Development and TherapyHongqing Zhao,1,2,* Yang Liu,1,2,* Na Cai,3 Xiaolin Liao,1,2 Lin Tang,2,4 Yuhong Wang1,2 1Science & Technology Innovation Center, Hunan University of Chinese Medicine, Changsha, Hunan, People’s Republic of China; 2Hunan Key Laboratory of ...
Zhao H +5 more
doaj
Discovery of Uracil Derivatives as Potent Inhibitors of Fatty Acid Amide Hydrolase
Molecules, 2016 Fatty Acid Amide Hydrolase (FAAH) is an intracellular serine enzyme involved in the biological degradation of the fatty acid ethanolamide family of signaling lipids, which exerts neuroprotective, anti-inflammatory, and analgesic properties.
Yan Qiu, Yang Zhang, Yuhang Li, Jie Ren
doaj +1 more source
HeliyonLipid metabolism in cancer refers to the alterations in how cancer cells process and utilize lipids, a type of fat molecule. It was investigated how lipid metabolism relates to osteosarcoma.
Yanbin Shi +4 more
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Endocannabinoid Involvement in Impulsivity and Decision-making [PDF]
, 2014 Problem gambling is a widespread phenomenon with a prevalence estimate of 2.3% globally (Williams, Volberg, & Stevens, 2012). Although little is known about the neurochemistry underlying this pathological behaviour, evidence suggests that dysregulation ...
Norris, Christopher P
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Targeting the Endocannabinoid Metabolic Enzymes to Reduce Inflammatory Pain [PDF]
, 2014 Pain is a debilitating condition that presents a problem of clinical relevance. Common analgesics include opioids and non-steroidal anti-inflammatory drugs (NSIADs).
Ghosh, Sudeshna
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