Results 161 to 170 of about 13,969 (210)

Synthesis and evaluation of isoquinolinyl and pyridinyl-based dual inhibitors of fatty acid amide hydrolase and soluble epoxide hydrolase to alleviate orofacial hyperalgesia in the rat. [PDF]

Biochem Biophys Rep
Carr D, Gunari S, Gorostiza G, Mercado M, Pavana L, Duong L, Gomez K, Salinas S, Garcia C, Tsang A, Morisseau C, Hammock BD, Pecic S, Kandasamy R.   +13 more
europepmc   +1 more source

Anti-Inflammatory Effects of Cannabinoids in Therapy of Neurodegenerative Disorders and Inflammatory Diseases of the CNS. [PDF]

Int J Mol Sci
Tomaszewska-Zaremba D, Gajewska A, Misztal T.   +2 more
europepmc   +1 more source

Differential inhibitory effects of endocannabinoids on neuronal firing of mouse meningeal afferents. [PDF]

J Headache Pain
Krivoshein G, Della Pietra A, Savinainen J, van den Maagdenberg AMJM, Giniatullin R.   +4 more
europepmc   +1 more source

The efficacy of elevating anandamide via inhibition of fatty acid amide hydrolase (FAAH) combined with internet-delivered cognitive behavioral therapy in the treatment of post-traumatic stress disorder: a randomized, placebo-controlled clinical trial. [PDF]

Neuropsychopharmacology
Mayo LM, Gauffin E, Petrie GN, Tansey R, Mazurka R, Haggarty CJ, Jones MR, Engelbrektsson H, Aminoff V, Hühne-Landgraf A, Schmidt ME, Pemberton DJ, Fredlund C, Östman L, Karlsson H, Löfberg A, Pietrzak M, Andersson G, Capusan AJ, Hill MN, Heilig M.   +20 more
europepmc   +1 more source

Targeting Endocannabinoid Signaling: FAAH and MAG Lipase Inhibitors

Annual Review of Pharmacology and Toxicology, 2021
Inspired by the medicinal properties of the plant Cannabis sativa and its principal component (−)- trans-Δ9-tetrahydrocannabinol (THC), researchers have developed a variety of compounds to modulate the endocannabinoid system in the human brain. Inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), which are the enzymes ...
Mario van der Stelt
exaly   +5 more sources

FAAH better anxiolytics? [PDF]

Nature Reviews Drug Discovery, 2003
exaly   +2 more sources

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Fluorimetric Assay of FAAH Activity

2022
Fatty acid amide hydrolase (FAAH) is the enzyme responsible for the degradation of anandamide (N-arachidonoylethanolamine, AEA) to arachidonic acid (AA) and ethanolamine. The method described here measures FAAH activity through the fluorometric arachidonoyl-7-amino-4-methyl-coumarin amide (AAMCA) substrate, which allows a simple and sensitive assay ...
Angelucci, Clotilde B, Giacominelli-Stuffler, Roberto, Maccarrone, Mauro   +2 more
openaire   +2 more sources