Results 61 to 70 of about 1,628,545 (288)

Human Umbilical Cord Blood Mononuclear Cell-Conditioned Media Inhibits Hypoxic-Induced Apoptosis in Human Coronary Artery Endothelial Cells and Cardiac Myocytes by Activation of the Survival Protein Akt

Cell Transplantation, 2013
We have previously demonstrated in acute myocardial infarctions that human umbilical cord blood mononuclear cells (HUCBCs), which contain hematopoietic, endothelial, and mesenchymal stem cells, reduce acute myocardial infarction size by ≥50% and preserve
Hua Jin, Paul R. Sanberg, Robert J. Henning   +2 more
doaj   +1 more source

The role of endothelial biomarkers in predicting damp-heat syndrome in diabetic kidney disease

Journal of Traditional Chinese Medical Sciences, 2022
Objective: To explore the role of endothelial biomarkers in predicting damp-heat syndrome in diabetic kidney disease (DKD). Methods: A total of 183 patients with DKD were divided into 3 groups: the early DKD group, established DKD group, and advanced DKD
Zhenjie Chen, Kai Yuan, Runze Yan, Hanwen Yang, Xiaona Wang, Yi Wang, Shuwu Wei, Weijun Huang, Weiwei Sun   +8 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Involvement of Hypoxia-Inducible Factor-1 in the Inflammatory Responses of Human LAD2 Mast Cells and Basophils [PDF]

, 2012
We recently showed that hypoxia-inducible factor 1 (HIF-1) plays a crucial role in the pro-allergic functions of human basophils by transcriptional control of energy metabolism via glycolysis as well as directly triggering expression of the angiogenic ...
Claire L Streatfield, Sumbayev, Vadim V., Yasinska, Inna M., Gibbs, Bernhard F., Streatfield, Claire L., Vadim V Sumbayev, Oniku, Abraham E., Bernhard F Gibbs, Streatfield Claire L., Yasinska Inna, Sumbayev Vadim V., Inna Yasinska, Oniku Abraham E., Gibbs Bernhard F., Abraham E Oniku   +14 more
core   +1 more source

The human factor H protein family – an update

Frontiers in Immunology
Complement is an ancient and complex network of the immune system and, as such, it plays vital physiological roles, but it is also involved in numerous pathological processes.
Noémi Sándor, Noémi Sándor, Andrea E. Schneider, Alexandra T. Matola, Veronika H. Barbai, Dániel Bencze, Hani Hashim Hammad, Alexandra Papp, Dorottya Kövesdi, Dorottya Kövesdi, Barbara Uzonyi, Barbara Uzonyi, Mihály Józsi, Mihály Józsi   +13 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering [PDF]

, 2004
Glycine receptors (GlyRs) and specific subtypes of GABA(A) receptors are clustered at synapses by the multidomain protein gephyrin, which in turn is translocated to the cell membrane by the GDP-GTP exchange factor collybistin.
Ward, H, Harvey, R.J., Alldred, Melissa J., Smart, T.G., Luscher, B, Duguid, Ian C, Lingenfelter, S E, Duguid, IC, Ward, H., Lingenfelter, Sue E., Alldred, M.J., Harvey, Robert J., Pearce, B R, Lundgren, J.D., Harvey, K, Owen, Michael John, Pearce, Brian R., Beatty, S.E., Smart, Trevor G., Owens, Max J., Keep, N H, Harvey, RJ, Lingenfelter, S.E., Harvey, Robert J, Keep, NH, Lundgren, J, Owen, MJ, Lund University., Ward, Hamish, Smart, T G, Pearce, B.R., Lüscher, Bernhard, Beatty, Sarah E., Lingenfelter, SE, Lundgren, Johan,, Keep, Nicholas H., Lundgren, Johan, Luscher, B., Harvey, K., Smart, TG, Alldred, M J, Beatty, SE, Owen, M J, Beatty, S E, Alldred, MJ, Rees, MI, Harvey, Kirsten, Duguid, I C, Rees, Mark I., Rees, M I, Duguid, I.C., Pearce, BR, Mark Rees, Rees, M.I.   +53 more
core   +1 more source

Morphologic, cytometric, quantitative transcriptomic and functional characterisation provide insights into the haemocyte immune responses of Pacific abalone (Haliotis discus hannai)

Frontiers in Immunology
In recent years, the abalone aquaculture industry has been threatened by the bacterial pathogens. The immune responses mechanisms underlying the phagocytosis of haemocytes remain unclear in Haliotis discus hannai.
Zeyuan Ma, Yunlong Wu, Yu Zhang, Weini Zhang, Mingmei Jiang, Xiaoyue Shen, Hailian Wu, Xinhua Chen, Xinhua Chen, Guilan Di   +9 more
doaj   +1 more source

Enolase From Aspergillus fumigatus Is a Moonlighting Protein That Binds the Human Plasma Complement Proteins Factor H, FHL-1, C4BP, and Plasminogen

Frontiers in Immunology, 2019
The opportunistic fungal pathogen Aspergillus fumigatus can cause severe infections, particularly in immunocompromised individuals. Upon infection, A. fumigatus faces the powerful and directly acting immune defense of the human host.
Prasad Dasari, Naile Koleci, Iordana A. Shopova, Dirk Wartenberg, Niklas Beyersdorf, Stefanie Dietrich, Alfredo Sahagún-Ruiz, Marc Thilo Figge, Marc Thilo Figge, Christine Skerka, Axel A. Brakhage, Axel A. Brakhage, Peter F. Zipfel, Peter F. Zipfel   +13 more
doaj   +1 more source

Dietary tryptophan supplementation enhances mitochondrial function and reduces pyroptosis in the spleen and thymus of piglets after lipopolysaccharide challenge

Animal, 2023
The thymus and spleen, the main reservoirs for T lymphocytes, modulate the innate immune response. Oxidative stress, excessive inflammation and abnormal pyroptosis can cause dysfunction of these organs.
Guangmang Liu, Weixiao Sun, Fang Wang, Gang Jia, Hua Zhao, Xiaoling Chen, Gang Tian, Jingyi Cai, Jing Wang   +8 more
doaj   +1 more source