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Complement Factor H related protein 1 and immune inflammatory disorders
Molecular Immunology, 2022Human complement Factor H-related protein 1 (FHR-1) is one of complement Factor H-related proteins (FHRs) and plays an important role in innate immunity. In particular, FHR-1 promotes complement activation by competing with Factor H (FH) for ligands on different surfaces or directly binding to C3b and native C3.
Xiangru, Li, Jing, Zong, Shaoyan, Si
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The complement factor H‐related proteins
Immunological Reviews, 2016SummaryThe role of the complement factor H‐related (FHR) proteins in homeostasis, pathogen defense, and autoimmune disease has recently attracted considerable interest. We highlight the exciting research that has contributed to our understanding of the FHR protein family. Unlike factor H, a potent negative regulator of complement C3 activation, the FHR
Medjeral-Thomas, N, Pickering, MC
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Complement factor H related proteins in immune diseases
Vaccine, 2008The complement system is a powerful part of the host innate immune defense and is aimed to damage and eliminate microbes and modified self-cells. To protect host cells and biological surfaces from damage mediated by complement activation products a tight control of the complement system is necessary.
Christine, Skerka, Peter F, Zipfel
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2013
Factor H-related proteins (CFHRs) are plasma glycoproteins related in structure and antigenicity to each other and to the complement inhibitory protein factor H. Such proteins are found in most mammals but their number and domain composition vary. This chapter summarizes our current knowledge on the human factor H-related proteins.
Józsi, Mihály, Meri, Seppo
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Factor H-related proteins (CFHRs) are plasma glycoproteins related in structure and antigenicity to each other and to the complement inhibitory protein factor H. Such proteins are found in most mammals but their number and domain composition vary. This chapter summarizes our current knowledge on the human factor H-related proteins.
Józsi, Mihály, Meri, Seppo
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Polymorphism and deficiency of human factor H-related proteins p39 and p37
Immunogenetics, 1992We described previously cDNA clones representing a novel factor H-related 1.4 kilobase mRNA. This mRNA species codes for a doublet of serum proteins of M(r) 39,000 and 37,000 (p39/p37). The respective recombinant proteins of the three clones H-69, pFH1.4a, and pFH1.4b differ in the expression of the epitope recognized by the monoclonal antibody (mAb ...
Elisabeth Feifel +7 more
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HUMAN COMPLEMENT FACTOR H RELATED PROTEIN TEST FOR MONITORING BLADDER CANCER
Journal of Urology, 2001The BTA stat test is a rapid, noninvasive, qualitative urine test that detects bladder tumor associated antigen (human complement factor H related protein) in urine. We compared BTA stat test to voided urine cytology in patients monitored for bladder cancer in a prospective trial, and determined whether this test is effective in detection of recurrence
M P, Raitanen +6 more
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Biochemical and functional characterization of the factor-H-related protein 4 (FHR-4)
Immunopharmacology, 1997Factor-H-related proteins and the complement regulatory protein factor H represent a family of structurally and immunologically related plasma proteins. The function of the various factor-H-related proteins are currently unclear and under investigation.
J, Hellwage, C, Skerka, P F, Zipfel
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Polymorphism of the factor H related proteins (FHRP)
Immunology Letters, 1997B.C. Dierl, A. Cannich, E.H. Weiss
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Factor H-related proteins in the pathogenesis of atypical hemolytic-uremic syndrome
Practical medicineAtypical hemolytic-uremic syndrome (aHUS) is a rare disease of the group of thrombotic microangiopathies caused by hyperactivation of an alternative pathway of the complement system. One of the mechanisms of aHUS development is the change in the functional activity of proteins of the factor H (FH) family. We analyzed the available data on the influence
KH. M. EMIROVA +10 more
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