Results 121 to 130 of about 40,684 (247)

Haemostatic changes and bleeding with anti‐IL‐6 directed therapy in autoimmune diseases

British Journal of Pharmacology, EarlyView.
Abstract Anti‐IL‐6 directed therapy, especially tocilizumab (TCZ), is widely used for the treatment of autoimmune diseases such as rheumatoid arthritis, giant cell arteritis and systemic juvenile idiopathic arthritis. Next to being a master regulator of inflammation, IL‐6 also is an important regulator of haemostasis. Although generally well tolerated,
Charlotte D. C. C. van der Heijden, Loes C. Oskam, Lenny van Bon, Chantal P. Rovers   +3 more
wiley   +1 more source

Impact of a factor Xa inhibitor (apixaban) on SIV pathogenesis and response to antiretroviral therapy. [PDF]

JCI Insight
Xu C, Annapureddy H, Carson L, Khurana V, Sivanandham R, Sivanandham S, He T, Raehtz KD, Kim J, Biber C, Arbujas-Silva N, Daira M, Kandasamy S, Feinstein MJ, Sereti I, Apetrei C, Pandrea I.   +16 more
europepmc   +1 more source

Mixed Super‐Circles

Computer Graphics Forum, EarlyView.
Abstract We introduce mixed super‐circles, a position‐curvature formulation of the original dynamic 2D super‐helix model. Compared to the latter, purely curvature‐based model – the so‐called chained formulation –, the mixed formulation that we propose here drastically reduces the algorithmic complexity of the solving scheme – from quadratic to quasi ...
Emile Hohnadel, Thibaut Métivet, Florence Bertails‐Descoubes   +2 more
wiley   +1 more source

Prothrombin complex concentrate for oral factor Xa inhibitor reversal prior to urgent invasive procedures. [PDF]

Transfusion
Shamiea M, Osnis A, Kashoua A, Avnery O, Itchaki G, Isman S, Tohami T, Jarchowsky-Dolberg O, Ellis M.   +8 more
europepmc   +1 more source

Targeting the Xa factor [PDF]

Nature Reviews Cardiology, 2017
openaire   +1 more source

Generative Cutout Animation

Computer Graphics Forum, EarlyView.
Abstract Cutout animation is one of the earliest forms of animation, and to this day remains a popular technique featured in numerous films including Monty Python and South Park series. Most computer animation systems, however, focus on different styles, including cel animation, making cutout animation somewhat underexplored.
Ivan Puhachov, Noam Aigerman, Thibault Groueix, Mikhail Bessmeltsev   +3 more
wiley   +1 more source

Andexanet Alfa for Life-Threatening Bleeding Following Factor Xa Inhibitor Treatment: Postmarketing Surveillance Study in Japan. [PDF]

JACC Asia
Sakamoto K, Ishihara M, Kato H, Kim H, Okuda M, Hiroki S, Koga M, Toyoda K.   +7 more
europepmc   +1 more source

Climate Regulation and ESG Disclosure in Maritime Transport

European Financial Management, EarlyView.
ABSTRACT This paper investigates whether climate policy signals influence ESG disclosure quality in maritime transport, a capital‐intensive industry responsible for roughly 3% of global CO₂ emissions. Using panel data from 126 listed shipping firms between 2009 and 2023, we construct an author‐based disclosure quality index and treat the IMO's 2018 ...
Xakousti Afroditi Merika, Theodore Syriopoulos   +1 more
wiley   +1 more source

Natural language processing (NLP)-assisted assessment of neurologic severity and functional outcomes in factor Xa inhibitor-related intracranial hemorrhages. [PDF]

Front Neurol
Sutton SS, Magagnoli J, Pittman R, Cummings TH, Ofori-Asenso R.   +4 more
europepmc   +1 more source

The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1

The FEBS Journal, EarlyView.
ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu, Maximilian J. L. J. Fürst, Oscar P. Kuipers   +2 more
wiley   +1 more source