The impact of systemic long‐term medications for the development of age‐related macular degeneration
Acta Ophthalmologica, EarlyView.Abstract Purpose Age‐related macular degeneration (AMD) is a leading cause of central vision loss in the elderly; however, the systemic factors that modulate its incidence and progression remain unclear. We sought to determine whether long‐term use of systemic medications, including diabetes and antithrombotic medications, corticosteroids and ...
Hanna Heloterä +3 more
wiley +1 more source
British Journal of Educational Psychology, EarlyView.Abstract Background University students around the world learn English as a foreign language (EFL) as it is considered vital for their post‐education opportunities locally and internationally. Optimising English language learning in EFL classrooms at the university is thus important.
Yoshiyuki Nakata +3 more
wiley +1 more source
Regularized reduced rank regression for mixed predictor and response variables
British Journal of Mathematical and Statistical Psychology, EarlyView.Abstract In this paper, we introduce the Generalized Mixed Regularized Reduced Rank Regression model (GMR4), an extension of the GMR3 model designed to improve performance in high‐dimensional settings. GMR3 is a regression method for a mix of numeric, binary and ordinal response variables, while also allowing for mixed‐type predictors through optimal ...
Lorenza Cotugno +2 more
wiley +1 more source
Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries
British Journal of Pharmacology, EarlyView.Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley +1 more source
Cancer Science, EarlyView.Hypericin induces autophagic AKT degradation by promoting AKT‐HSPA5 interaction in an S473 phosphorylation‐dependent manner, suppressing HCC growth. It enhances CD8+ T cell‐mediated antitumor immunity and synergizes with anti‐PD‐L1 therapy, showing favorable safety for HCC treatment. ABSTRACT Hepatocellular carcinoma (HCC) is the most prevalent primary
Sien Ma +12 more
wiley +1 more source
Computer Graphics Forum, EarlyView.Abstract We introduce mixed super‐circles, a position‐curvature formulation of the original dynamic 2D super‐helix model. Compared to the latter, purely curvature‐based model – the so‐called chained formulation –, the mixed formulation that we propose here drastically reduces the algorithmic complexity of the solving scheme – from quadratic to quasi ...
Emile Hohnadel +2 more
wiley +1 more source
Experimental Determination of Calcite Solubility in H2O‐KCl‐NaCl‐LiCl Solutions at 700°C and 8 kbar
Geophysical Monograph Series, Page 245-257., 2020 This book is Open Access. A digital copy can be downloaded for free from Wiley Online Library.
Explores the behavior of carbon in minerals, melts, and fluids under extreme conditions
Carbon trapped in diamonds and carbonate-bearing rocks in subduction zones are examples of the continuing exchange of substantial carbon ...
James Eguchi, Yuan Li, Craig E. Manning
wiley +1 more source
Computer Graphics Forum, EarlyView.Abstract Cutout animation is one of the earliest forms of animation, and to this day remains a popular technique featured in numerous films including Monty Python and South Park series. Most computer animation systems, however, focus on different styles, including cel animation, making cutout animation somewhat underexplored.
Ivan Puhachov +3 more
wiley +1 more source
Enoxaparin Dosing and Target anti-Factor Xa Achievement in Infants by Postmenstrual Age. [PDF]
J Pediatr Pharmacol TherPerez D, Mathew K.
europepmc +1 more source