Results 91 to 100 of about 644,115 (313)

Direct Factor Xa Inhibitors Versus Warfarin in Non-Valvular Atrial Fibrillation: Efficacy, Safety, Cost, and Reversibility [PDF]

, 2016
Atrial fibrillation is a common cause for stroke. Vitamin K antagonists such as warfarin are an effective prophylactic medication to prevent stroke in patients with atrial fibrillation.
Jacobs, Cory D.
core   +1 more source

Identification and functional analysis of novel phosphorylation sites in the RNA surveillance protein Upf1. [PDF]

, 2013
One third of inherited genetic diseases are caused by mRNAs harboring premature termination codons as a result of nonsense mutations. These aberrant mRNAs are degraded by the Nonsense-Mediated mRNA Decay (NMD) pathway.
Bracho, Dina P, Cajigas, Iván J, Correa, María E, Estrella, Luis A, González, Carlos I, González-Feliciano, José A, Lasalde, Clarivel, León, Alfredo J, Rivera, Andrea V, Rodríguez-Cruz, Eva N, Vega, Irving E, Wilkinson, Miles F   +11 more
core   +1 more source

Reversing factor Xa inhibitors – clinical utility of andexanet alfa

Journal of Blood Medicine, 2017
Approximately half of patients started on an oral anticoagulant in the USA now receive one of the newer direct oral anticoagulants (DOACs). Although there is an approved reversal agent for the direct thrombin inhibitor dabigatran, a specific reversal ...
S. Kaatz, H. Bhansali, Joseph J Gibbs, R. Lavender, C. Mahan, David Paje   +5 more
semanticscholar   +1 more source

Effect of time to start of biologic therapy on treatment response in childhood arthritis: Results from the UCAN CAN‐DU study

Arthritis &Rheumatology, Accepted Article.
Objective To estimate the effect of time from symptom onset to start of biologic treatment on achieving inactive arthritis within six months in a cohort of juvenile idiopathic arthritis (JIA) patients. Methods The international UCAN CAN‐DU study prospectively enrolls JIA patients across Canada and the Netherlands.
Jelleke B. de Jonge, Sytze de Roock, Dieneke Schonenberg‐Meinema, J. Merlijn van den Berg, Deborah A. Marshall, Sebastiaan J. Vastert, Rae S.M. Yeung, Joost F. Swart, Susanne M. Benseler, The UCAN CAN‐DU and UCAN CURE consortia, Adam Huber, Alan Rosenberg, Alexander Mosoiu, Alisa Rachlis, Amy Xu, Andrea Human, Annet van Royen‐Kerkhof, Arthur Cheng, Berent Prakken, Bianca Lang, Brenleigh Jebb, Brian Feldman, Bruno Pereira, Chelsea DeCoste, Ciarán Duffy, Claire LeBlanc, Clare Hutchinson, Daniah Basodan, Danielle Brinkman, David Cabral, Dax G. Rumsey, Deborah Levy, Dilan Dissanayake, Elizabeth Legger, Elizabeth Stringer, Elizaveta Limenis, Ellen Schatorje, Elodie Boudes, Erika Van Nieuwenhove, Erkan Demirkaya, Esther Hoppenreijs, Evelyn Rozenblyum, Gaëlle Chédeville, Gillian Currie, Giske Biesbroek, Gordon Soon, Harper Cheng, Heinrike Schmeling, Herman Tam, Hon Yan Ng, Jaime Guzman, Jeanine McColl, Jennifer Ji Young Lee, Jonathan Park, Joseph Cafazzo, Kate Neufeld, Kim Morishita, Kristin Houghton, Liane Heale, Lillian Lim, Lily Lim, Lori Tucker, Lynn Spiegel, Maarten IJzerman, Marc Jansen, Mariken Gruppen, Marinka Twilt, Marleen Verkaaik, Mehul Jariwala, Mercedes Chan, Michelle Batthish, Michelle Kip, Muhammed Dhalla, Nadia Luca, Nickolas Blanchette, Nico Wulffraat, Nicole Johnson, Paivi Miettunen, Paul Dancey, Petra Hissink Muller, Philomine van Pelt, Piya Lahiry, Ravneet Sran, Rayfel Schneider, Rebeka Stevenson, Regina de Geus, Roberta Berard, Roman Jurencak, Ronald Laxer, Rosie Scuccimarri, Ross Petty, Ruud Verstegen, Sarah Campillo, Shirley Tse, Suzanne Ramsey, Sylvia Kamphuis, Tala El Tal, Tania Cellucci, Tara McGrath, Tommy Gerschman, Trang Duong, Tristan Kerr, Wineke Armbrust   +102 more
wiley   +1 more source

Is There an Alternative Oral Anticoagulation to Vitamin-K-Antagonists for Patients with Mechanical Aortic Valve Replacement? – A Literature Review

Cardiology and Therapy
Current guidelines exclusively recommend vitamin-K-antagonists (VKA) as anticoagulation for patients after mechanical aortic valve replacement due to the increased postoperative risk of valve thrombosis and thrombo-embolism.
Stephen Gerfer, Thorsten Wahlers, Elmar Kuhn   +2 more
doaj   +1 more source

PAR1 Agonists Stimulate APC-Like Endothelial Cytoprotection and Confer Resistance to Thromboinflammatory Injury [PDF]

, 2018
Stimulation of protease-activated receptor 1 (PAR1) on endothelium by activated protein C (APC) is protective in several animal models of disease, and APC has been used clinically in severe sepsis and wound healing.
Aisiku, Omozuanvbo, Ceunynck, Karen De, Chaudhry, Sharjeel A., Dockendorff, Chris, Fitch-Tewfik, Jennifer L., Flaumenhaft, Robert, Higgins, Sarah J., Ingber, Donald E., Jain, Abhishek, Parikh, Samir M., Peters, Christian G.   +10 more
core   +1 more source

Neck‐vein thrombosis during spaceflight

British Journal of Clinical Pharmacology, EarlyView.
Spaceflight imposes unique environmental challenges, including weightlessness, increased radiation exposure and confinement, which can lead to unexpected health effects. One such example is neck‐vein thrombosis, a condition rarely seen on Earth without predisposing factors such as venous catheters or infections.
Ulrich Limper, Jens Jordan
wiley   +1 more source

Assessing Safety of Direct Thrombin Inhibitors, Direct Factor Xa Inhibitors and Vitamin K Antagonists in Patients with Atrial Fibrillation: A Nation-Wide Propensity Score Matched Cohort from Sweden

Clinical Epidemiology, 2020
Marie Linder,1 Anastasia Iliadou Nyman,2,3 Helle Kieler,1 Bengt Danielsson,2 Natalia Borg,2 Marcus Gry,2 Julius Collin2 1Centre for Pharmacoepidemiology, Karolinska Institutet, T2, Karolinska University Hospital, Stockholm, Sweden; 2The National Board of
Linder M, Iliadou Nyman A, Kieler H, Danielsson B, Borg N, Gry M, Collin J   +6 more
doaj  

Advances in Preventive Therapy for Estrogen-Receptor-Negative Breast Cancer. [PDF]

, 2014
Preventing breast cancer is an effective strategy for reducing breast cancer deaths. The purpose of chemoprevention (also termed preventive therapy) is to reduce cancer incidence by use of natural, synthetic, or biological agents.
Brown, Powel H, Litzenburger, Beate C
core   +1 more source

Glycosaminoglycans as Polyelectrolytes: Charge, Interactions, and Applications

ChemBioChem, EarlyView.
Glycosaminoglycans (GAGs) are linear, anionic biopolymers with their functions tightly linked to their charge. This review approaches GAGs from a polyelectrolyte perspective, shedding light on how the distribution of sulfate groups and, thus, negative charges, governs their interactions with other biomolecules.
Gergo Peter Szekeres, Eunjin Moon, Johanna K. Elter, Bryce Roper, Jayachandran Narayanan Nair Kizhakkedathu, Matthias Ballauff, Rainer Haag, Kevin Pagel   +7 more
wiley   +1 more source