Results 61 to 70 of about 219,223 (326)
FAK inhibition disrupts tumor growth, apoptosis, and transcriptional regulation in GI-NETs
Endocrine OncologyBackground: Gastrointestinal neuroendocrine tumors (GI-NETs) are rare neoplasms with limited therapeutic options and increasing clinical incidence. Focal adhesion kinase (FAK) has been implicated in oncogenic processes across various tumor types; however,
Lara Toffoli +6 more
doaj +1 more source
Differential alphav integrin-mediated Ras-ERK signaling during two pathways of angiogenesis. [PDF]
, 2003 Antagonists of alphavbeta3 and alphavbeta5 disrupt angiogenesis in response to bFGF and VEGF, respectively. Here, we show that these alphav integrins differentially contribute to sustained Ras-extracellular signal-related kinase (Ras-ERK) signaling in ...
Cheresh, David A +4 more
core +1 more source
Advanced Healthcare Materials, EarlyView.Our study showed that human primary gingival fibroblast–derived microvesicles on nano‐engineered titanium implants promote early osseointegration and soft‐tissue attachment in vivo. ABSTRACT Titanium dental implants require both reliable osseointegration and peri‐implant soft tissue seal formation to ensure long‐term success. While osseointegration has
Pingping Han +10 more
wiley +1 more source
The roles of nuclear focal adhesion kinase (FAK) on Cancer: a focused review
Journal of Experimental & Clinical Cancer Research, 2019 FAK is a tyrosine kinase overexpressed in cancer cells and plays an important role in the progression of tumors to a malignant phenotype. Except for its typical role as a cytoplasmic kinase downstream of integrin and growth factor receptor signaling ...
Jin Zhou, Qian Yi, Liling Tang
doaj +1 more source
The Journal of Cell Biology, 2006 Focal adhesion kinase (FAK) transduces adhesion forces into pro-proliferation signals in a variety of cell types. Now, Pirone et al. (page [277][1]) show that FAK also inhibits proliferation when cells lack adequate attachments.
openaire +1 more source
LKB1 Represses Focal Adhesion Kinase (FAK) Signaling via a FAK-LKB1 Complex to Regulate FAK Site Maturation and Directional Persistence [PDF]
Journal of Biological Chemistry, 2013 Liver kinase β1 (LKB1, also known as STK11) is a serine/threonine kinase that has multiple cellular functions including the regulation of cell polarity and motility. Murine proteomic studies show that LKB1 loss causes aberrant adhesion signaling; however, the mechanistic underpinnings of this relationship are unknown. We show that cells stably depleted
Erik R, Kline +4 more
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.xx xx. ABSTRACT Osseointegration of orthopedic and dental implants is influenced by local and systemic factors, including their physicochemical surface properties and the patient's overall health status. Titanium and its alloys have been a longstanding standard for bone implants due to their innate biocompatibility and mechanical properties.
Dainelys Guadarrama Bello +2 more
wiley +1 more source
Journal of Integrative NeuroscienceBackground: Bone cancer pain (BCP) is a common primary or metastatic bone cancer complication. Netrin-1 plays an essential role in neurite elongation and pain sensitization.
Zhihao Gong +6 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Background: Phosphorylated Focal adhesion kinase (FAK) has been reported to be intimately involved in various malignant tumors. The effect of p-FAK on colorectal cancer (CRC) is still disputable.
Guanyu Yu +9 more
doaj +1 more source
Oxygen and ROS Delivery for Infected Wound Healing and Future Prospects
Advanced Healthcare Materials, EarlyView.Bacterial infection is a major driver of delayed wound healing and postsurgical readmissions; with rising antibiotic resistance, solid peroxide–releasing biomaterials offer sustained delivery of ROS/O2 for antimicrobial control and microenvironmental modulation.
Ayden Watt +7 more
wiley +1 more source