Results 111 to 120 of about 340,370 (339)

Ocrelizumab‐induced colitis: VigiBase disproportionality analysis, case reports and literature review

British Journal of Clinical Pharmacology, EarlyView.
Aims Ocrelizumab is a humanized anti‐CD20 monoclonal antibody used in multiple sclerosis. Since its commercialization, several cases of ocrelizumab‐induced colitis have been reported in the scientific literature. Methods To explore the potential association of ocrelizumab with colitis as an adverse drug reaction (ADR), we conducted a descriptive and ...
Audrey Fresse, Christophe Hommel, Nadine Petitpain, Philippe Kerschen   +3 more
wiley   +1 more source

Efficacy and Safety of Alirocumab in Adults With Homozygous Familial Hypercholesterolemia: The ODYSSEY HoFH Trial.

Journal of the American College of Cardiology, 2020
BACKGROUND Homozygous familial hypercholesterolemia (HoFH) is characterized by extremely elevated low-density lipoprotein-cholesterol (LDL-C) levels and early onset atherosclerotic cardiovascular disease despite treatment with conventional lipid-lowering
D. Blom, M. Harada‐Shiba, P. Rubba, D. Gaudet, J. Kastelein, M. Charng, R. Pordy, S. Donahue, Shazia Ali, Yuping Dong, N. Khilla, P. Banerjee, M. Baccara-Dinet, R. Rosenson   +13 more
semanticscholar   +1 more source

A Scoping Review of Electronic Health Records–Based Screening Algorithms for Familial Hypercholesterolemia

BackgroundFamilial hypercholesterolemia (FH) is a common genetic disorder that is strongly associated with premature cardiovascular disease. Effective diagnosis and appropriate treatment of FH can reduce cardiovascular disease risk; however, FH is ...
Khoury, Muin J., Otchere, Baffour, Osei, Jeffery, Coronado, Fatima, Akyea, Ralph K., Bonful, Gracelove, Razavi, Alexander C., Akoto, Natalie, Kolor, Katherine, Mensah, George A., Sperling, Laurence, Moonesinghe, Ramal, Qureshi, Nadeem   +12 more
core   +1 more source

Familial hypercholesterolemia: experience from France

, 2018
International audiencePurpose of review We provide an overview of molecular diagnosis for familial hypercholesterolemia in France including descriptions of the mutational spectrum, polygenic susceptibility and perspectives for improvement in familial ...
Jean-Pierre Rabès, Alain Carrié, Sophie Béliard, Rabes, Jean-Pierre, Beliard, Sophie, Carrie, Alain   +5 more
core   +1 more source

Decoding RNA regulation: Challenges and opportunities for RNA‐based therapies in Europe

British Journal of Clinical Pharmacology, EarlyView.
Abstract RNA‐based medicinal products represent a promising frontier in personalised medicine, offering sequence‐specific disease targeting at various molecular levels, yet their clinical translation in the European Union (EU) may be hindered by regulatory uncertainty around definitions and evidence requirements; this study therefore aims to identify ...
Olivia C. Lewis, Christine Leopold, Joyce M. Hoek, Raymond M. Schiffelers, Marie L. De Bruin   +4 more
wiley   +1 more source

Premature Coronary Artery Disease due to Homozygous Familial Hypercholesterolemia in a 12-Year-Old Girl

Balkan Medical Journal, 2018
Background: Homozygous familial hypercholesterolemia is a rare inherited metabolic disease caused by low-density lipoprotein receptor abnormality.
Filiz Ekici, Salih Özçobanoğlu, Fırat Kardelen   +2 more
doaj   +1 more source

Diagnostic Yield of Sequencing Familial Hypercholesterolemia Genes in Severe Hypercholesterolemia

Journal of the American College of Cardiology, 2016
Background About 7% of US adults have severe hypercholesterolemia (untreated LDL cholesterol ≥190 mg/dl). Such high LDL levels may be due to familial hypercholesterolemia (FH), a condition caused by a single mutation in any of three genes.
A. Khera, H. Won, G. Peloso, Kim S Lawson, Traci M. Bartz, Xuan Deng, E. V. van Leeuwen, P. Natarajan, C. Emdin, Alexander G. Bick, A. Morrison, J. Brody, N. Gupta, A. Nomura, T. Kessler, S. Duga, J. Bis, C. V. van Duijn, L. Cupples, B. Psaty, D. Rader, J. Danesh, H. Schunkert, R. McPherson, M. Farrall, H. Watkins, E. Lander, James G. Wilson, A. Correa, E. Boerwinkle, P. Merlini, D. Ardissino, D. Saleheen, S. Gabriel, S. Kathiresan   +34 more
semanticscholar   +1 more source

Familial Hypercholesterolemia: A Genetic and Metabolic Study.

Annals of Internal Medicine, 1965
Excerpt A large family having familial hypercholesterolemia with a complete pedigree dating from 1732 was studied to define the inheritance, clinical manifestations, and biochemical features.
WILLIAM R. HARLAN, JOHN B. GRAHAM, E. HARVEY ESTES   +2 more
openaire   +1 more source

The power of many: when genetics met yeasts and high‐throughput

Biological Reviews, EarlyView.
ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley   +1 more source

Analysis of Differentially Expressed Genes and Molecular Pathways in Familial Hypercholesterolemia Involved in Atherosclerosis: A Systematic and Bioinformatics Approach

Frontiers in Genetics, 2020
Background and Aims: Familial hypercholesterolemia (FH) is one of the major risk factor for the progression of atherosclerosis and coronary artery disease.
S. Udhaya Kumar, D. Thirumal Kumar, R. Bithia, Srivarshini Sankar, R. Magesh, Mariem Sidenna, C. George Priya Doss, H. Zayed   +7 more
semanticscholar   +1 more source