Results 111 to 120 of about 20,467 (242)

Oxysterols in Cancer: From Biosynthesis and Pathophysiology to Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Mechanisms by which oxysterol targeting may enhance immunotherapy efficacy. This figure illustrates potential metabolic interventions that may improve antitumor immunity by modulating oxysterol related pathways. CH25H modulation may reduce 25‐HC accumulation, promote the conversion of cold tumors into hot tumors, and increase T cell infiltration and PD‐
Haili Shang, Yongsheng Li
wiley   +1 more source

Optical mapping reveals a higher level of large‐scale structural variants in a family with paternally transmitted myotonic dystrophy and independent Parkinson's disease

The Journal of Pathology, Volume 270, Issue 1, Page 83-97, September 2026.
Abstract Myotonic dystrophy type 1 (DM1) is a clinically challenging multisystem neuromuscular hereditary disorder, with generational increase in severity and earlier age at onset. It is caused by an unstable cytosine‐thymine‐guanine repeat expansion at the DMPK locus, accompanied by associated genetic and epigenetic modifications.
Md Mehedi Hasan, Jenna Craddock, Tingting Gong, Ruth J Lyons, Igor Stevanovski, Sanjog R Chintalaphani, Ira W Deveson, Weerachai Jaratlerdsiri, Kishore R Kumar, Vanessa M Hayes   +9 more
wiley   +1 more source

Lipid management: Insights from NICE clinical guidelines 2023

Heart Vessels and Transplantation
Khalil Ahmad Ahrari
doaj   +1 more source

Hearing Loss and Modifiable Dementia Risk Factors in Adults Aged 50 Years or Older Living in Tasmania, Australia

Australasian Journal on Ageing, Volume 45, Issue 3, September 2026.
ABSTRACT Objective This study examined the associations between hearing loss (HL) and other modifiable dementia risk factors in adults aged 50 years or older living in Tasmania and explored the effects of corrected versus uncorrected HL on these factors. Methods A cross‐sectional study design using an online survey categorised participants as No‐HL, HL‐
Mohammad Shoaib Hamrah, Kathleen Doherty, Aidan Bindoff, Lynette R. Goldberg, Jane Alty, Alex Kitsos, Eddy Roccati, Claire Eccleston, Anna King, Thomas Gregor Issac, Hiroshi Yatsuya, James Clement Vickers   +11 more
wiley   +1 more source

Postpartum Body Weight and Cardiometabolic Biomarker Trajectories in Women With Gestational Diabetes: A Population‐Based Matched Cohort Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 9, Page 8254-8265, September 2026.
ABSTRACT Aims To compare postpartum trajectories in body weight and cardiometabolic biomarkers between women with and without GDM, and to explore the moderating effect of progression to type 2 diabetes (T2DM). Materials and Methods We used electronic primary care healthcare records and linked hospital episode records of women who gave birth between ...
Ruya Abdulsalam, Susan A. Jebb, Moscho Michalopoulou, Carmen Piernas, Richard Stevens, Nerys M. Astbury   +5 more
wiley   +1 more source

Familial Hypercholesterolemia [PDF]

Circulation, 2020
openaire   +2 more sources

Health Service Delivery Outcomes From Nursing in Genomics: A Scoping Review of the Literature (2012–2025)

International Nursing Review, Volume 73, Issue 3, September 2026.
ABSTRACT Aim This study aimed to summarize the current state of the science for “health service delivery–oriented outcomes” from nursing in genomics (2012–2025). Background Nurses can play a vital role in increasing access to genomic healthcare and improving outcomes for patients, families, and communities.
Jordan N. Keels, Joanne Thomas, Kathleen A. Calzone, Laurie Badzek, Sarah Dewell, Emma T. Tonkin, Andrew A. Dwyer   +6 more
wiley   +1 more source

A Metabolomic Signature Predicts Gout Flare Clinical Outcome Associated With Colchicine Prophylaxis

Arthritis &Rheumatology, Volume 78, Issue 8, Page 1765-1775, August 2026.
Objective This study investigated that serum metabolomics, before urate‐lowering therapy (ULT) initiation, could serve as a biomarker for responsiveness to colchicine prophylaxis in patients with gout commencing treat‐to‐target ULT. Methods We studied a multicenter prospective cohort (n = 409) initiating treat‐to‐target ULT plus colchicine prophylaxis.
Wenyan Sun, Lingfang Xu, Haibing Chen, Mingshu Sun, Zhiqiang Li, Rui Li, Lidan Ma, Hui Zhang, Aichang Ji, Yuwei He, Na Wu, Le Yan, Robert Terkeltaub, Changgui Li   +13 more
wiley   +1 more source

Atherosclerosis at Warp Speed: The Urgent Lessons of Homozygous Familial Hypercholesterolemia. [PDF]

JACC Case Rep
Drossner D.
europepmc   +1 more source

Prescribing competence: The pros and cons of different methods for assessment

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2429-2442, August 2026.
Evaluating a medical graduate’s competence in rational prescribing is challenging. With the aim to guide and inspire teachers, this narrative review explores different methods that can be used to assess prescribing competence. Each method has its own advantages and disadvantages, and thus a mix of different assessment methods is needed throughout the ...
David J. Brinkman, Erik M. Donker, Jelle Tichelaar, on behalf of the CP4T programme   +3 more
wiley   +1 more source