Epilepsia, EarlyView.Abstract Objective Absence epilepsy is characterized by brief but frequent seizures with loss of consciousness. Existing treatments, which come with heavy side effects, are only partially effective and do not address the associated comorbidities, including cognitive and social deficits.
Coline Rulhe +9 more
wiley +1 more source
Efficacy of alirocumab in high cardiovascular risk populations with or without heterozygous familial hypercholesterolemia: Pooled analysis of eight ODYSSEY Phase 3 clinical program trials [PDF]
, 2016 Michel Farnier +5 more
openalex +1 more source
The FEBS Journal, EarlyView.High serum cholesterol is linked to colorectal cancer liver metastases (CRCLM) subtypes with poor survival (replacement pattern). Levels of cholesterol under 4 mmol·L−1 correlated with better survival and a desmoplastic pattern subtype. Furthermore, in vivo PCSK9 inhibitor evolocumab, which lowers cholesterol, reduced liver metastases.
Amatzia Gantz +9 more
wiley +1 more source
Molecular Genetics and Metabolism ReportsBackground: Familial hypercholesterolemia (FH) results in elevated LDL cholesterol, contributing to atherosclerosis and early-onset cardiovascular disease.
Mai Thi Thanh Do +5 more
doaj +1 more source
Impact of a common mutation of the LDL receptor gene, in French‐Canadian patients with familial hypercholesterolemia, on means, variances and correlations among traits of lipid metabolism [PDF]
, 1995 Madeleine Roy +3 more
openalex +1 more source
Haemophilia, EarlyView.ABSTRACT Background The clinical focus of haemophilia has expanded beyond bleeding outcomes to encompass long‐term comorbidities such as cardiovascular disease (CVD). However, it remains unclear when vascular changes begin in this population. Carotid intima‐media thickness (cIMT), a validated, non‐invasive marker of subclinical atherosclerosis, may ...
Alyson Trillo +5 more
wiley +1 more source
Journal of the Pakistan Medical AssociationObjectives: To assess knowledge, attitude and practice of physicians regarding familial hypercholesterolemia. Method: The cross-sectional study was conducted from October to December 2022 in Aljouf, Tabouk, Hail and northern border regions of Saudi ...
Aseel Awad Alsaidan
doaj +1 more source
Penetrating Atherosclerotic Ulcer of the Descending Thoracic Aorta in a Patient with Heterozygote Familial Hypercholesterolemia [PDF]
, 1994 Kihoon Han +3 more
openalex +1 more source
How do index patients participating in genetic screening programmes for familial hypercholesterolemia (FH) interpret their DNA results?:A UK-based qualitative interview study [PDF]
, 2011 Douglas, Margaret +6 more
core +1 more source
Study of LDL receptor gene mutations in patients with familial hypercholesterolemia in Chaharmahal va Bakhtiari province. [PDF]
, 2010 چکیده: زمینه و هدف: هایپرکلسترولمی فامیلی (FH) بیماری غالب اتوزومال است که عمدتاً بدلیل جهش در ژن گیرنده لیپوپروتئین با دانسیته کم (LDLR) ایجاد می شود.
Asadi, Somayeh. +9 more
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