Results 151 to 160 of about 234,426 (253)

Clinical considerations on the use of evinacumab for the treatment of homozygous familial hypercholesterolemia. [PDF]

Am J Prev Cardiol
Bajaj A, McGuire M, Shugg S, Godin R, Underberg JA.   +4 more
europepmc   +1 more source

Clustering of Cerebral Microbleeds in Cerebral Amyloid Angiopathy: A Flow Territory‐Based Analysis

Journal of Magnetic Resonance Imaging, Volume 64, Issue 5, Page 1241-1249, November 2026.
ABSTRACT Background Cerebral microbleeds (CMBs) are a key imaging marker of cerebral amyloid angiopathy (CAA), but their individual spatial distribution and potential clustering remain poorly understood. Purpose This study assessed whether CMBs exhibit patient‐specific, flow territory‐based clustering in sporadic (sCAA) and Dutch‐type hereditary CAA (D‐
Manon R. Schipper, Reinier G. J. van der Zwet, Jelle J. Goeman, Thijs W. van Harten, Emma A. Koemans, Marieke J. H. Wermer, Marianne A. A. van Walderveen, Matthias J. P. van Osch   +7 more
wiley   +1 more source

Comparison of Clinical Characterization and Therapeutic Strategies between Homozygous Familial Hypercholesterolemia and Heterozygous Familial Hypercholesterolemia. [PDF]

J Atheroscler Thromb
Shishikura D, Harada-Shiba M, Michikura M, Sakaguchi K, Kusumoto H, Fujioka S, Fujisaka T, Kanzaki Y, Morita H.   +8 more
europepmc   +1 more source

Effectiveness of LDL Apheresis Techniques for Reducing LDL‐C in Familial Hypercholesterolemia: A Systematic Review and Meta‐Analysis [PDF]

Health Sci Rep
ABSTRACT Objective Familial hypercholesterolemia (FH) is a common inherited disorder characterized by markedly elevated low‐density lipoprotein cholesterol (LDL‐C) levels and an increased risk of premature cardiovascular disease. LDL apheresis is an extracorporeal procedure used to remove atherogenic lipoproteins from the circulation and is an ...
Derakhshani N, Rezapour A, Pouyan S, Rezapour R, Arabloo J, Soleimanpour S, Afshari S, Ariamand A.   +7 more
europepmc   +2 more sources

Atherosclerosis: From Pathogenesis to Therapeutic Interventions

MedComm, Volume 7, Issue 11, November 2026.
The diagram outlines the core mechanisms driving atherosclerosis, including endothelial dysfunction, inflammatory responses, phenotypic switching of smooth muscle cells, and the gut–vascular axis. It also presents the corresponding therapeutic approaches now under development, such as gene therapies, immunotherapies, and nanotechnology platforms ...
Enge Zhou, Chenxi Zhan, Yuting Li, Yi Zeng, Renfei Luo, Xin Ouyang, Shixing Liu, Renqiang Yang, Nianlong Yan, Long Jiang   +9 more
wiley   +1 more source

Tendinopathy: Types, Epidemiology, Molecular Mechanisms, and Future Precision‐Oriented Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
This review presents tendinopathy as a heterogeneous disorder driven by dynamic interactions among mechanical sensing, inflammation, angiogenesis and innervation, and extracellular matrix remodeling. Integrating clinical phenotypes with imaging, biomarkers, and multi‐omics may enable molecular subtyping and mechanism‐guided interventions, advancing ...
Yang Wu, Junyi Long, Meng Yang, Hongjie Huang, Jianquan Wang   +4 more
wiley   +1 more source

Atherosclerosis at Warp Speed: The Urgent Lessons of Homozygous Familial Hypercholesterolemia. [PDF]

JACC Case Rep
Drossner D.
europepmc   +1 more source

Lipidomic profiling in patients with familial hypercholesterolemia: Abnormalities in glycerolipids and oxysterols

Lipidomic profiling in patients with familial hypercholesterolemia: Abnormalities in glycerolipids and ...
Shiva Ganjali (14682088), RD Santos (15863654), A Sahebkar (7797281), V Cardenia (20835683), A Bonciolini (20835686), K Al-Rasadi (20835689)   +5 more
core  

Pharmacological and Therapeutic Potential of Garlic (Allium sativum): Integrating Phytochemistry, Molecular Mechanisms, and Clinical and Preclinical Evidence

ChemistryOpen, Volume 15, Issue 11, November 2026.
Garlic bioactive compounds, including organosulfur compounds (allicin, DADS, DATS, and SAC), phenolic compounds, and quercetin, regulate the Nrf2/HO‐1, NF‐κB, PI3K/Akt, and AMPK/eNOS signaling pathways. These actions enhance antioxidant defenses, suppress inflammation, improve metabolic and cardiovascular function, and contribute to reduced blood ...
Gudisa Bereda
wiley   +1 more source

Multilevel correlates of physical activity programming preferences in young adult cancer survivors

Pediatric, Adolescent &Young Adult Cancer, Volume 1, Issue 1, November 2026.
Abstract Introduction Physical activity (PA) levels remain low among young adult (YA) cancer survivors despite existing interventions. Although programming preferences are critical for intervention design, research on the factors associated with these preferences is limited. Methods This cross‐sectional study surveyed YAs diagnosed with cancer (aged 18–
Nashira I. Brown, Ana Paula S. Rodrigues, Acadia W. Buro, Marilyn Stern, Tiffany L. Carson   +4 more
wiley   +1 more source